COVID-19 in HSCT recipients: a collaborative study of the Brazilian Society of Marrow Transplantation (SBTMO) Research Published on 2022-01-132022-10-05 Journal: Bone marrow transplantation [Category] SARS, 바이오마커, 임상, [키워드] addition Allogeneic autologous Brazil C-reactive protein children COVID-19 Critical death Diagnosis diagnosis of SARS-CoV-2 died disorders high mortality rate HSCT HSCT recipient increased risk infected with SARS-CoV-2 initial Laboratory test Marrow multicenter National Patient patients died preventive measure receiving RT-PCR SARS-COV-2 infection severity of symptom Society Stem cell transplantation survival transplantation urea vaccination [DOI] 10.1038/s41409-021-01561-x [Article Type] Research
A Portrait of SARS-CoV-2 Infection in Patients Undergoing Hematopoietic Cell Transplantation: A Systematic Review of the LiteratureSystematic Review Published on 2022-01-132022-10-31 Journal: Current Oncology [Category] COVID-19, SARS, [키워드] 95% CI age Allogeneic autologous Cell Controlled COVID-19 decreased mortality described determine Efficacy Efficacy and safety Factor Features HCT hematopoietic Hematopoietic cell transplant high risk ICU admission immune dysregulation increased mortality literature management Meta-analysis morbidity and mortality Mortality mortality rate MOST OVID pediatric performance Platelet Portrait Potential treatment presenting Prognostic factors recipient recipients reported required review Risk of bias SARS-CoV-2 Symptom systematic review Treatment Vaccine with COVID-19 [DOI] 10.3390/curroncol29010030 PMC 바로가기 [Article Type] Systematic Review
Robust COVID-19 vaccination response after allogeneic stem cell transplantation using post transplantation cyclophosphamide conditioningCorrespondence Published on 2022-01-122022-10-28 Journal: Blood Cancer Journal [Category] COVID-19, [키워드] acute myeloid leukaemia Allogeneic Bone marrow transplantation COVID-19 vaccination Cyclophosphamide Stem cell transplantation [DOI] 10.1038/s41408-021-00605-1 PMC 바로가기 [Article Type] Correspondence
Latency reversal plus natural killer cells diminish HIV reservoir in vivoArticle Published on 2022-01-102022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] administration Allogeneic anti-retroviral therapy approach Cell cellular clone Combination diminishe effective eliminated HIV HIV infection HIV infections HIV-1 humanized in vivo infected cells inhibiting injection kill killing latency mice natural killer cell Peripheral blood persistence previous study Protein reduce reduced shown subset Viral reservoir Viral reservoirs Viremia virus [DOI] 10.1038/s41467-021-27647-0 PMC 바로가기 [Article Type] Article
Two Doses of BNT162b2 mRNA Vaccine in Patients after Hematopoietic Stem Cell Transplantation: Humoral Response and Serological Conversion PredictorsArticle Published on 2022-01-102022-10-31 Journal: Cancers [Category] COVID-19, [키워드] addition adverse event adverse events Allogeneic allogeneic transplantation Analysis anti-SARS-CoV-2 antibody anti-SARS-CoV-2 vaccination antibody autologous B-cell BNT162b2 mRNA vaccine CNI collected Concentration conversion correlated COVID-19 COVID-19 pandemic dose Efficacy Efficacy and safety examined HCT Hematological malignancies hematopoietic hematopoietic stem cell transplantation humoral Humoral response immune response predictors immunogenic Immunosuppressive treatment inhibitor intensity knowledge lack lymphocyte subpopulation mRNA mRNA vaccine multivariate model of BNT162b2 Patient patients Post-vaccine predictor predictors remained response SARS-CoV-2 SARS-COV-2 infection searched Seroconversion serological simple STEM Stem cell transplantation Treatment Univariate analysis vaccination [DOI] 10.3390/cancers14020325 PMC 바로가기 [Article Type] Article
Antibody response after 2 and 3 doses of SARS-CoV-2 mRNA vaccine in allogeneic hematopoietic cell transplant recipients동종 조혈모세포 이식 환자에서 SARS-CoV-2 mRNA 백신 2, 3회 투여 후 항체 반응Observational Study Published on 2022-01-062022-09-12 Journal: Blood [Category] 비임상, 임상, 진단, [키워드] Allogeneic Cell dose mRNA vaccine recipient SARS-CoV-2 [DOI] 10.1182/blood.2021014232 PMC 바로가기 [Article Type] Observational Study
Severe aplastic anemia after COVID-19 mRNA vaccination: Causality or coincidence?코로나19 mRNA 백신 접종 후 중증 재생불량성 빈혈: 인과관계인가 우연인가?Case Reports Published on 2022-01-012022-09-12 Journal: Journal of autoimmunity [Category] 진단, [키워드] administration Allogeneic allogeneic HSCT Anemia anti-SARS-CoV-2 antibodies antibody Antibody titer Aplastic anemia association Autoimmune disease Autoimmune diseases bone bone marrow failure Bone marrow transplantation Causality COVID-19 COVID-19 infection COVID-19 vaccine Hematopoietic stem cell HSCT Immune-mediated involved mRNA Pathogenesis Patient Pfizer-BioNTech mRNA vaccine replaced reported SARS-CoV-2 Spike protein Stem cell transplantation syndrome the patient the SARS-CoV-2 treated vaccination Vaccinations Vaccine [DOI] 10.1016/j.jaut.2021.102782 PMC 바로가기 [Article Type] Case Reports
Hematopoietic Cell Transplantation is Feasible in Patients with Prior COVID-19 Infection이전 COVID-19 감염 환자에서 조혈 세포 이식이 가능합니다Article Published on 2022-01-012022-09-11 Journal: Transplantation and cellular therapy [Category] SARS, 치료기술, [키워드] Acute lymphoblastic leukemia acute myelogenous leukemia Allogeneic anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody antibody autologous Cell cell transplantation Characteristics chronic myelogenous leukemia Cohort consecutive patient coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 disease COVID-19 infection Descriptive statistics detectable Diagnosis died disease eight Follow-up fungal Graft-versus-host disease HCT Hematologic malignancy hematopoietic Hematopoietic cell transplantation IgG antibodies IgG antibody Infection initial leukemia Lymphoblastic leukemia lymphoid lymphoma Multiple myeloma Myelodysplastic syndrome myelofibrosis myelogenous leukemia Myeloma one patient outcome Patient patients with asymptomatic performed Pneumonia positive progression of disease recurrence remained retained Retrospective analysis SARS CoV SARS CoV-2 SARS Cov-2 antibody seroconversion. selected Seroconversion Seven susceptible symptomatic COVID-19 disease syndrome tested transplantation Treatment were used [DOI] 10.1016/j.jtct.2021.10.004 PMC 바로가기 [Article Type] Article
Secretome of Mesenchymal Bone Marrow Stem Cells: Is It Immunosuppressive or Proinflammatory?Article Published on 2021-12-012022-11-16 Journal: Bulletin of experimental biology and medicine [Category] SARS, 치료기술, [키워드] Allogeneic Anti-inflammatory approved Autoimmune disease bone Bone marrow cause Cell cell transplantation characterized chemokine Clinical use condition conditions COVID-19 patient Culture cytokine profile Cytokine storm Cytokines disease functions Graft-versus-host disease GVHD hematopoietic stem cell transplantation IL-10 IL-4 IL-6 IL-8 IMPROVE Intensive Marrow MCP-1 mesenchymal stem cell Mesenchymal stem cells MSC Pathogenesis proinflammatory protocols reaction reduce required risk STEM stem cells therapeutic therapy tolerogenic Treatment [DOI] 10.1007/s10517-021-05371-5 PMC 바로가기
Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial5 개의 면역 저하 환자 및 전향 적 개방형 임상 시험에서 건강한 대조군에서 SARS-COV-2에 대한 mRNA BNT162B2 백신의 안전성 및 효능Research paper Published on 2021-11-302022-08-13 Journal: EBioMedicine [Category] MERS, SARS, 임상, [키워드] Adverse adverse events Adverse reaction Allogeneic allogeneic hematopoietic stem cell transplantation Antibody titre antibody titres BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccination CAR T, Chimeric antigen receptor T CAR-T Cell Cell therapy certain immunocompromised patient groups chronic lymphocytic leukemia clinical trial clinical trials CLL CLL, Chronic lymphocytic leukemia Control controls Council COVID-19, Coronavirus disease 2019 disorder Efficacy event excluded finding FIVE five group foundation funding generally mild group healthy control healthy controls Hematopoietic stem cell highlight HIV HIV, Human immunodeficiency virus HSCT, Allogeneic hematopoietic stem cell transplantation Human immunodeficiency virus human stem-cell transplantation Ibrutinib Immunity Immunocompromised Immunocompromised patient immunocompromised patient group Immunocompromised patients immunodeficiency disorder immunodeficiency disorders IMPROVE Infection ITT, Intention to treat Knut leukemia Lymphocytic leukemia mPP, Modified per protocol mRNA BNT162b2 vaccine mRNA vaccination mycophenolate mycophenolate mofetil occurred of BNT162b2 Open-label organ transplantation organization organizations Patient patient group patient groups PID, Primary immunodeficiency disorders PP, Per protocol primary endpoint Primary Immunodeficiency Prospective clinical trial Rate Region Safe Safety SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 second dose secondary endpoint Secondary endpoints selected serious adverse reaction Seroconversion seroconversion rate seroconverted solid organ solid organ transplantation SOT SOT, Solid organ transplantation stem cell subgroups subject Swedish T cell therapy Treatment vaccination against COVID-19 vaccine dose virus infection [DOI] 10.1016/j.ebiom.2021.103705 PMC 바로가기 [Article Type] Research paper