Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis
Research paper
[키워드] affecting
aggregation
ALS
Amyotrophic lateral sclerosis
approved
cause
Compound
COVID-19
cysteine
demonstrated
develop
disease
disease onset
dominant
drug
drug design
Ebselen
education
enzyme
finding
funding
gene encoding
improvement
in vitro
involved
Japan
ligand-bound
Lou Gehrig
mice
motor neuron
motor neuron disease
mutant
Mutation
neurodegeneration
Neurological disorder
neuronal cell
novel
offer
pathogenic
performed
Prevent
protease
Riluzole
Science
significantly
SOD1
sports
stability
Structure
supported
technology
the disease
therapeutic
therapeutic benefits
Therapeutic compounds
therapeutic effect
therapeutic potential
these compound
Toxicity
transgenic
Treatment
utilised
viral disease
wild-type
[DOI] 10.1016/j.ebiom.2020.102980 PMC 바로가기 [Article Type] Research paper
[DOI] 10.1016/j.ebiom.2020.102980 PMC 바로가기 [Article Type] Research paper