Rationale and design of the pragmatic randomized trial of icosapent ethyl for high cardiovascular risk adults (MITIGATE)심혈관 위험이 높은 성인을 위한 icosapent ethyl의 실용적인 무작위 시험의 이론적 근거 및 설계(MITIGATE)Multicenter Study Published on 2021-05-012022-09-11 Journal: American heart journal [Category] 임상, [키워드] age anti-inflammatory property Antiviral approved atherosclerotic Atherosclerotic cardiovascular disease by mouth Cardiopulmonary cardiovascular disease cardiovascular risk Care clinical effectiveness clinical observation clinical observations Clinical practice clinical status clinical trial clinics co-primary endpoint co-primary endpoints cohort of patient consequence control group coronavirus disease Coronavirus disease 2019 COVID-19 downstream elevated evaluate Evidence fatty Fatty acid Follow-up Health Health care Health status hospital Icosapent icosapent ethyl Intervention laboratory-confirmed mitigate morbidity and mortality mouth omega-3 omega-3 fatty acid Open-label participant pleiotropic effect Pleiotropic effects Pragmatic Preclinical preclinical data prescription medication Prevent purified Randomized randomized trial rationale reduce reduction in respiratory infection seasonal flu statin stratified therapy triglycerides upper respiratory infection usual care viral upper respiratory infection. [DOI] 10.1016/j.ahj.2021.01.018 PMC 바로가기 [Article Type] Multicenter Study
The Anti-inflammatory Effect of the Tricyclic Antidepressant Clomipramine and Its High Penetration in the Brain Might Be Useful to Prevent the Psychiatric Consequences of SARS-CoV-2 InfectionPharmacology Published on 2021-03-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] “cytokine storm” animal models anti-inflammatory action anti-inflammatory property antidepressant antidepressants Blood brain barrier Brain caused clomipramine complications consequence Consequences coronavirus disease COVID-19 death Dexamethasone disease Effect effective explain help imperative in vitro in vivo indicated Inflammation management Mental neurological manifestations penetrate Prevent psychiatric diseases Psychiatric disorders psychiatric pathology reduce repositioning respiratory SARS-CoV SARS-CoV-2 SARS-COV-2 infection shown Tocilizumab Tricyclic viral encephalitis viral infection worsening [DOI] 10.3389/fphar.2021.615695 PMC 바로가기 [Article Type] Pharmacology
Negative Association Between Mediterranean Diet Adherence and COVID-19 Cases and Related Deaths in Spain and 23 OECD Countries: An Ecological StudyNutrition Published on 2021-03-052022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] acute respiratory syndrome adherence adjusted Analysis anti-inflammatory property approach association biological basis chronic disease Cohort studies Comorbidity confounding factor coronavirus Coronavirus disease 2019 country COVID-19 COVID-19 case COVID-19 patients death deaths diet driving ecological examined explain Factor healthy healthy diet hypertension immune function Mediterranean diet mitigate negative obesity outcome pandemic Perspective Physical inactivity Prevalence Region remained risk factor risk reduction SARS-COV-2 infection Spain Study design type 2 diabetes Wuhan, China [DOI] 10.3389/fnut.2021.591964 PMC 바로가기 [Article Type] Nutrition
Dysfunctional Inflammation in Cystic Fibrosis Airways: From Mechanisms to Novel Therapeutic ApproachesReview Published on 2021-02-162022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] airway airway epithelial cells anti-inflammatory agent anti-inflammatory property anti-inflammatory treatment apical surface caused CFTR CFTR modulators chloride channel chronic airway inflammation clinical benefits consequence Critical Cystic cystic fibrosis develop disorder drug dysfunction Effect effort epithelial Evidence exacerbate expressed fibrosis gene encoding Infection Inflammation Inflammatory investigated lung damage mechanism microenvironment molecular Mutation novel pathogen pathophysiology patients Protein recent finding responsible SARS-COV-2 infection several limitation shown subsequent susceptibility Therapeutic approach therapeutic approaches therapeutic strategy Traditional transmembrane Transport Treatment turn viral infection [DOI] 10.3390/ijms22041952 PMC 바로가기 [Article Type] Review
Diarylureas: Repositioning from Antitumor to Antimicrobials or Multi-Target Agents against New PandemicsReview Published on 2021-01-192022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] against SARS-CoV agent anti-inflammatory property Antibiotics anticancer antimalarial antimicrobial Antimicrobials Antithrombotic Antiviral Antiviral treatment biological activities bis-arylurea Compound COVID-19 COVID-19 pandemic declined diarylurea Diseases Drug discovery East Efficacy effort events highlight moderate disease New New coronavirus pandemic Pandemics Patient Pneumonia regions reported repositioning restrict Safe SARS-CoV Severe case sorafenib therapeutic strategy these compound tyrosine kinase inhibitor variant viral infection virus with mild disease [DOI] 10.3390/antibiotics10010092 PMC 바로가기 [Article Type] Review
Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infectionsArticle Published on 2021-01-072022-10-04 Journal: Cell Death & Disease [Category] 진단, [키워드] Activation administration alleviate anti-inflammatory property biological processe Bronchoalveolar lavage fluid chemokine circulating co-culture co-cultured Concentration correlated counteract COVID-19 patients disease severity Effect Host implication in viral in vitro indicate Inflammation Inflammatory diseases Inflammatory response Influenza inhibiting innate immune response Interleukins lung Lung injury Lymphocytes Macrophage MAPK microenvironment mitigate neutrophil NF-κB signaling Pathways Pneumonia pro-inflammatory cytokine pulmonary inflammation reduced respiratory epithelial cell Respiratory tract diseases respiratory viral infection respiratory viral infections shown significantly Stat1 STAT3 therapeutic therapeutic target transcriptomic virus [DOI] 10.1038/s41419-020-03283-2 PMC 바로가기 [Article Type] Article
Beneficial effect of Indigo Naturalis on acute lung injury induced by influenza A virusResearch Published on 2020-12-212022-11-01 Journal: Chinese Medicine [Category] COVID-19, [키워드] Activation acute lung injury administration Alanine ALT animal Anti-inflammatory anti-inflammatory property Aspartate aminotransferase AST BALB/c mice canine Cell Chinese coronavirus disease COVID-19 cytokine Cytokines ELISA evaluated expressed expression H1N1 IAV IFN-α IFN-β IFN-γ IL-10 IL-6 in vitro Indigo Naturalis Inflammation Influenza influenza A virus influenza viruses inhibited inoculated interferon interferon γ interleukin-6 intranasally IP-10 kidney liver liver index Lung injury lung tissue MCP-1 MDA mechanism mice monocyte chemoattractant protein-1 Mortality MPO multi organ failure myeloperoxidase nitric oxide organ pandemic peritoneal macrophage Protein RANTES reduced regulated Respiratory Coronavirus Result SARS-CoV-2 secreted significantly significantly increased spleen staining suppressed survival rate T cell TCM TLR4 TNF-α toll-like receptor 4 treat treated Treatment tumor necrosis factor-α viral replication virus replication were recorded [DOI] 10.1186/s13020-020-00415-w PMC 바로가기 [Article Type] Research
Bee Venom—A Potential Complementary Medicine Candidate for SARS-CoV-2 InfectionsPublic Health Published on 2020-12-102022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] ACE-2 Activation acute respiratory syndrome administration angiotensin-converting enzyme 2 anti-inflammatory property Arthritis bee bee venom bee venom in clinical trials candidate cellular characterized China complementary complementary medicine and alternative medicine coronavirus COVID-19 and complementary medicine Cytokine storm syndrome disease Efficacy Epidemiological study expression Extracellular H1N1 HIV humoral IFN-γ IgE IgG antibodies IL-6 IL-8 immune system Immunity immunize Inflammation interact interferon-γ interleukin-6 kinase Local management Medicine melittin Neurological diseases NF-κB non-enveloped viruses nuclear offer Pathways pharmokinetics of bee poison Phospholipase A2 Potential proinflammatory cytokines Protein receptor SARS-CoV-2 SARS-CoV-2 (2019-nCoV) SARS-CoV-2 infections suppress therapy TNF-α tumor necrosis factor-α virus [DOI] 10.3389/fpubh.2020.594458 PMC 바로가기 [Article Type] Public Health
Reply to “Antiviral and anti-inflammatory properties of ivermectinand its potential use in Covid-19”"이버멕틴의 항바이러스 및 항염증 특성 및 Covid-19에서의 잠재적 사용"에 대한 답변Comment Published on 2020-12-012022-09-11 Journal: Monatsschr Kinderheilkd (1902) [Category] SARS, 치료제, [키워드] anti-inflammatory property Reply [DOI] 10.1016/j.arbr.2020.11.002 PMC 바로가기 [Article Type] Comment
Antiviral and anti-inflammatory properties of ivermectin and its potential use in Covid-19Correspondence Published on 2020-12-012022-10-05 Journal: Archivos de bronconeumología [Category] 치료제, [키워드] anti-inflammatory property Ivermectin [DOI] 10.1016/j.arbr.2020.06.006 [Article Type] Correspondence