Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies신종 코로나바이러스에 대해 일반적으로 처방되는 항우울제의 강력한 항바이러스 활성: 시험관 내 및 실리코 약물 용도 변경 연구Article Published on 2022-07-282022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] activities activity amitriptyline anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Anti-viral antidepressant antidepressants antiviral activity clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Depression disorder disorders drug eating disorders effective Efficacy eight evaluated FDA-approved drug FDA-approved drugs FIVE imipramine in silico in vitro in vivo M pro MERS MERS-CoV migraine molecular docking studies Molecular docking study neuralgia pandemic Paroxetine Patient performed Prophylaxis protease reported symptom Result SARS-CoV-2 sertraline suggested symptomatic and asymptomatic symptoms of depression treating COVID-19 Treatment [DOI] 10.1038/s41598-022-17082-6 PMC 바로가기 [Article Type] Article
Length-dependent motions of SARS-CoV-2 frameshifting RNA pseudoknot and alternative conformations suggest avenues for frameshifting suppressionSARS-CoV-2 frameshifting RNA pseudoknot 및 대체 형태의 길이 의존적 움직임은 frameshifting 억제를 위한 길을 제안합니다Article Published on 2022-07-252022-09-11 Journal: Nature Communications [Category] Coronavirus, COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] Analysis Anti-viral assumed build conformation conformational conserved experiments heterogeneous inhibit Interaction linear mechanism molecular molecular dynamics motif mRNA mutant observation pathway polyproteins required RNA SARS-CoV-2 structures therapeutic target translation [DOI] 10.1038/s41467-022-31353-w PMC 바로가기 [Article Type] Article
Natural tannins as anti-SARS-CoV-2 compounds항 SARS-CoV-2 화합물로서의 천연 탄닌Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] activities activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 Anti-viral anticancer drugs antioxidants biological function Biological functions cellular Compound coronavirus COVID-19 pandemic defined derivative effort family food additives fruits indication knowledge molecular natural outbreak over Pandemics plants SARS-CoV-2 seeds severe acute respiratory syndrome Coronavirus tannin tannins terminology variety wood [DOI] 10.7150/ijbs.74676 PMC 바로가기 [Article Type] Review
Potent neutralization by monoclonal human IgM against SARS-CoV-2 is impaired by class switchSARS-CoV-2에 대한 단일 클론 인간 IgM에 의한 강력한 중화는 클래스 전환에 의해 손상됩니다Article Published on 2022-07-052022-09-12 Journal: EMBO Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated Anti-viral antibodies antibody Antigen B cell B cells binding cell sorting class switch concentrations Donor expected explain human cells IgA IgG IgM IgM antibodies infected with SARS-CoV-2 MACACS membrane membrane antigen. monoclonal neutralization parents potent SARS-CoV-2 the antibody Virus neutralization [DOI] 10.15252/embr.202153956 PMC 바로가기 [Article Type] Article
Biotransformation and transplacental transfer of the anti-viral remdesivir and predominant metabolite, GS-441524 in pregnant rats임신한 쥐에서 항바이러스성 렘데시비르와 주요 대사산물인 GS-441524의 생체변환 및 태반 전이Article Published on 2022-07-012022-09-11 Journal: EBioMedicine [Category] 치료제, [키워드] amniotic Amniotic fluid Anti-viral approved AUC Biotransformation Blood Blood-placental barrier C max coronavirus disease Coronavirus disease 2019 COVID-19 cross during pregnancy evaluated fetus GS-441524 Hypothesis Liquid chromatography mass spectrometry maternal blood metabolite Microdialysis MONITOR mother multisite nucleoside parameter pharmacokinetic pharmacokinetics Placenta placental barrier predominant Pregnancy pregnant RATs Remdesivir Science shown Taiwan Tandem mass spectrometry technology tissues transfer treat Treatment UHPLC was used while [DOI] 10.1016/j.ebiom.2022.104095 PMC 바로가기 [Article Type] Article
COVID-19 patient with B Cell Lymphoma co-morbidity managed with co-administration of Ayurvedic formulationCase report Published on 2022-07-012022-10-05 Journal: Journal of Ayurveda and Integrative Medicine [Category] 진단, 치료제, [키워드] Achyranthe Ageusia Aloe Anti-viral antipyretics Antiviral approach Ayurveda Cancer chemotherapy cycle chronic co-morbidity condition COVID-19 COVID-19 pandemic COVID-19 patient Diagnosis Eclipta Efficacy Embelia Fever First wave glycyrrhiza home quarantine Host immune response host response Immunocompromised immunocompromised status immunomodulatory In vitro studies infective Intervention Kidney disease lymphoma malaise male modulate oxygen saturation Patient positive regimen remained replicated respiratory complication RT-PCR supported took place treat treated Vitamin was done [DOI] 10.1016/j.jaim.2022.100632 [Article Type] Case report
Multifaceted roles of plant derived small molecule inhibitors on replication cycle of SARS-CoV-2SARS-CoV-2의 복제 주기에 대한 식물 유래 소분자 억제제의 다면적 역할Review Published on 2022-07-012022-09-11 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affected Anti-inflammatory anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity Anti-viral antioxidant antiviral therapeutics approved assembly caused clinical trial compounds coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 drug candidate Economy Factor Google Scholar help highlight Host inhibiting knowledge mechanism New coronavirus plant plants platform polyprotein public health registry Replication SARS-CoV-2 SARS-COV-2 infection small molecule small molecule inhibitor Small molecule inhibitors Small molecules therapeutic approaches therapy Vaccine viral entry Viral replication cycle. [DOI] 10.1016/j.micpath.2022.105512 PMC 바로가기 [Article Type] Review
Randomized double-blind placebo-controlled proof-of-concept trial of resveratrol for outpatient treatment of mild coronavirus disease (COVID-19)Randomized Controlled Trial Published on 2022-06-292022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료법, 치료제, [키워드] 95% CI adverse event age anti-inflammatory property Anti-viral ARMS assigned chose clinically coronavirus disease COVID-19 demonstrated determine double-blind Effect FDA female group Hospitalization incidence IND measure Mild mitigate one patient outcome Outpatient participant Patient Phase 2 study Placebo placebo-controlled Pneumonia primary outcome measure randomization Randomly receive recruited resveratrol single dose small sample size statistically Symptom treated Treatment Trial Vitamin D3 was determined was used [DOI] 10.1038/s41598-022-13920-9 PMC 바로가기 [Article Type] Randomized Controlled Trial
Sequence-Specific Features of Short Double-Strand, Blunt-End RNAs Have RIG-I- and Type 1 Interferon-Dependent or -Independent Anti-Viral Effects짧은 이중 가닥, 평활 말단 RNA의 서열 특이적 특징은 RIG-I 및 유형 1 인터페론 의존성 또는 독립적 항바이러스 효과를 갖는다Article Published on 2022-06-282022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, 치료제, [키워드] adaptors Adenovirus Anti-viral anti-viral effect Antiviral Antiviral agents Antiviral effect antiviral effects assays Cell cell cycle cell cycle genes cell line cells cellular complementary cytoplasmic DNA DNA virus downregulated dsRNA dsRNAs Effect elicited fibroblast Gene Expression H3N2 human airway IFN IFN-alpha IFN-I IFNAR2 independent independent of indicated Infection Influenza influenza A influenza A virus Influenza virus interferon knock-out library MDA5 mechanism mimicking molecular patterns MYD88 organism Organisms pathogen pathogen-associated molecular patterns Pathogens Randomized receptor required retinoic acid retinoic acid-inducible gene I RIG-I RNA RNA therapy RNA virus RNAs SARS-CoV-2 sequence short double-strand blunt-end RNA. transcriptomics transfection Type ZNFX1 [DOI] 10.3390/v14071407 PMC 바로가기 [Article Type] Article
Repurposing antiviral phytochemicals from the leaf extracts of Spondias mombin (Linn) towards the identification of potential SARSCOV-2 inhibitors잠재적인 SARSCOV-2 억제제의 식별을 위해 스폰디아스 몸빈(Spondias mombin, Linn)의 잎 추출물에서 항바이러스 파이토케미컬을 용도 변경Article Published on 2022-06-282022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] 3CL pro absence acute respiratory symptoms acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-viral Antiviral approved approved drug approved drugs binding free energy candidate Compound coronavirus 2 disease domain Dynamics exhibited free energy in vitro in vivo indicated inhibitor inhibitors investigated molecular dynamics molecular dynamics simulations momentum pattern persistence polymerase protease public health RBD Receptor-binding domain reported repurposing respiratory S-protein SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 viral Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spondia target the SARS-CoV-2 therapeutic Toxicity Vaccine vaccine availability Vaccine hesitancy viral mutation [DOI] 10.1038/s41598-022-14558-3 PMC 바로가기 [Article Type] Article