Favipiravir and/or nitazoxanide: a randomized, double-blind, 2×2 design, placebo-controlled trial of early therapy in COVID-19 in health workers, their household members, and patients treated at IMSS (FANTAZE)Favipiravir 및/또는 nitazoxanide: IMSS(FANTAZE)에서 치료를 받는 의료 종사자, 가족 구성원 및 환자를 대상으로 한 COVID-19 조기 치료에 대한 무작위, 이중 맹검, 2x2 설계, 위약 대조 시험Randomized Controlled Trial Published on 2022-07-222022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] 1:1 2×2 design absence Admission antimicrobial Antimicrobials Antiviral effect antiviral therapy Antiviral treatment antivirals appear assigned Asymptomatic blinded to treatment combination therapy Comorbidities Comorbidity Controlled trial COVID-19 COVID-19 disease disease double-blind early disease early phase early treatment example Favipiravir followed by Gender Genetic genetic mutation Health high risk Hospitalization Hypothesis in some include individuals Infection Inflammatory Influenza intensive care investigator investigators later phase morbidity and mortality Mutation mutation rate nitazoxanide obesity older patient outcome pandemic participant patients treated pharmacokinetics phase phase IIa Placebo placebo-controlled placebo-controlled clinical trial placebo-controlled trial positive presence or absence Prevent Primary outcome progression protocol randomised randomised controlled trial Randomized receive replicates SARS-CoV-2 secondary Secondary outcomes security Sepsis severe disease smoking status Social Security Stratification symptomatic symptomatic COVID-19 Symptoms tested the disease therapy those with comorbidity Toxicity treatment allocation Trial upper respiratory tract Viral load virus [DOI] 10.1186/s13063-022-06533-0 PMC 바로가기 [Article Type] Randomized Controlled Trial
Mouthrinses against SARS-CoV-2 – High antiviral effectivity by membrane disruption in vitro translates to mild effects in a randomized placebo-controlled clinical trialSARS-CoV-2에 대한 구강청결제 - 시험관 내 막 파괴에 의한 높은 항바이러스 효과는 무작위 위약 대조 임상 시험에서 약한 효과로 해석됩니다.Randomized Controlled Trial Published on 2022-07-152022-09-11 Journal: Virus research [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] Analysis antiseptic Antiseptic agents Antiviral Antiviral effect BAC benzalkonium Benzalkonium chloride can be used capsid Capsid protection assay Cell culture chloride clinical evaluation clinical evaluations COVID-19 disrupting Effect effective intervention evaluated human population in vitro inactivated Infection route Measures membrane Mild minor mouthrinse Mouthwash oral cavity placebo-controlled clinical trial qPCR Randomized reduce reduction respiratory RT-qPCR SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 subsequent translate Transmission transmission rate transmission rates Treatment variety viral envelope Viral load viral loads Viral RNA virus was used without affecting [DOI] 10.1016/j.virusres.2022.198791 PMC 바로가기 [Article Type] Randomized Controlled Trial
Duration of infectious viral shedding in patients with mild to moderate COVID-19 treated with REGN-CoV2REGN-CoV2로 치료받은 경증 내지 중등도의 COVID-19 환자에서 감염성 바이러스 배출 기간Article Published on 2022-07-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral effect approved caused Clinical course Clinical efficacy collected coronavirus coronavirus disease COVID-19 Culture Delta delta variant drug Duration effective Efficacy groups Hiroshima Infection inhibitory concentration investigated Isolation Mild Mild disease mild to moderate mild to moderate disease Moderate COVID-19 moderate disease New Patient patients with COVID-19 PCR testing performed Pharyngeal swab reduced REGN-CoV2 respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly shorter Spread strain study period treated Treatment treatment methods university Viral viral culture viral mutation Viral mutations viral shedding virus virus culture virus strain with mild disease [DOI] 10.1016/j.jiac.2022.03.013 PMC 바로가기 [Article Type] Article
The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2뉴클레오사이드/뉴클레오타이드 유사체 테노포비르와 엠트리시타빈은 SARS-CoV-2에 대해 비활성입니다Article Published on 2022-06-302022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] accelerated active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity antiviral agent Antiviral agents Antiviral effect approaches approved approved drug biochemical causative pathogen caution Cell clinicians and researcher Concentration coronavirus COVID-19 COVID-19 pandemic demonstrated Efficiency emtricitabine epithelial FTC HIV-1 HIV-1 NRTI human lung in vitro data inactive indicate inhibitor lack metabolite NHBE NTP nucleoside polymerase Prevent RdRP RdRp active site required reverse transcriptase RNA polymerase SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus TAF TDF tenofovir Tenofovir alafenamide the SARS-CoV-2 transcriptase treat unlikely [DOI] 10.3390/molecules27134212 PMC 바로가기 [Article Type] Article
Sequence-Specific Features of Short Double-Strand, Blunt-End RNAs Have RIG-I- and Type 1 Interferon-Dependent or -Independent Anti-Viral Effects짧은 이중 가닥, 평활 말단 RNA의 서열 특이적 특징은 RIG-I 및 유형 1 인터페론 의존성 또는 독립적 항바이러스 효과를 갖는다Article Published on 2022-06-282022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, 치료제, [키워드] adaptors Adenovirus Anti-viral anti-viral effect Antiviral Antiviral agents Antiviral effect antiviral effects assays Cell cell cycle cell cycle genes cell line cells cellular complementary cytoplasmic DNA DNA virus downregulated dsRNA dsRNAs Effect elicited fibroblast Gene Expression H3N2 human airway IFN IFN-alpha IFN-I IFNAR2 independent independent of indicated Infection Influenza influenza A influenza A virus Influenza virus interferon knock-out library MDA5 mechanism mimicking molecular patterns MYD88 organism Organisms pathogen pathogen-associated molecular patterns Pathogens Randomized receptor required retinoic acid retinoic acid-inducible gene I RIG-I RNA RNA therapy RNA virus RNAs SARS-CoV-2 sequence short double-strand blunt-end RNA. transcriptomics transfection Type ZNFX1 [DOI] 10.3390/v14071407 PMC 바로가기 [Article Type] Article
Cysteamine exerts in vitro antiviral activity against the SARS-CoV-2 Delta and Omicron variants Research Published on 2022-06-152022-10-05 Journal: Cell Death Discovery [Category] 신약개발, 유전자 메커니즘, 치료제, [키워드] addition Affect Analysis antiviral action antiviral activity Antiviral effect applied calu-3 cells Cell COVID-19 disease culture media cysteamine Cytopathic effect cytotoxicity deaths Delta delta variant Effect effective evaluate had no humans Immune escape immunomodulatory effect in vitro inhibiting lack management Mutation omicron performed randomized clinical trials reduce reduced released reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants severe disease significantly survival the SARS-CoV-2 Therapies Transmissibility transmission electron microscopy Treatment Vaccine variant variants Vero E6 VERO E6 cells virus viruses VoC while wild type strain [DOI] 10.1038/s41420-022-01080-8 [Article Type] Research
HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effectHIV 프로테아제 억제제 Nelfinavir 및 Lopinavir/Ritonavir는 항바이러스 효과가 없음에도 불구하고 SARS-CoV-2에 감염된 시리아 햄스터의 폐 병리를 현저하게 개선합니다Article Published on 2022-06-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] accompanied activated neutrophil Activated neutrophils Adhesion Molecule adhesion molecules Alter Antiretroviral therapy antiviral activity Antiviral effect appear Blood Combination component CXCL8 did not reduce expression hamster hamsters highly active HIV HIV protease inhibitor human neutrophil human neutrophils immunomodulatory effect IMPROVE in vitro increase in independent independent of induce Infectious virus infiltration of neutrophil infiltration of neutrophils interstitium lack Lopinavir Lopinavir/ritonavir lung Lung pathology Migration nelfinavir neutrophil Neutrophils non-infected Protease inhibitor protease inhibitors protective effect receptor reported Ritonavir SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 titre Treatment treatment of HIV Viral viral RNA load [DOI] 10.1016/j.antiviral.2022.105311 PMC 바로가기 [Article Type] Article
SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5SARS-CoV-2 ORF7a는 숙주 인자 SERINC5의 항바이러스 효과를 강력하게 억제합니다Article Published on 2022-05-262022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome coronavirus Antiviral effect biogenesis Cell fusion cellular coronavirus 2 counteract evaluated expressed Factor HIV Host Human Human immunodeficiency virus immunodeficiency virus incorporation information inhibit involved ORF7a Protein respiratory restrict retroviruses SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SERINC5 Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sphingolipid transmembrane protein turn virion virions virus infectivity while [DOI] 10.1038/s41467-022-30609-9 PMC 바로가기 [Article Type] Article
Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitroArticle Published on 2022-05-192022-10-04 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] Air-liquid interface airway epithelium Antiviral Antiviral effect Antiviral treatment BSA can be used cellular Combination complementary coronavirus coronavirus strain CRISPR-Cas systems cultures dependent on Endemic ENhance human coronaviruses human primary cells in vitro Infection inhibit magnitude mutations new SARS-CoV-2 offer omicron Prophylaxis reduced reduction RNA SARS-CoV-2 SARS-CoV-2 variant significantly small molecule drug Synthetic biology therapeutic effect treat Treatment vaccination variant variants viral evolution Viral RNA viral titer [DOI] 10.1038/s41467-022-30546-7 PMC 바로가기 [Article Type] Article
Dopamine Reduces SARS-CoV-2 Replication In Vitro through Downregulation of D2 Receptors and Upregulation of Type-I Interferons도파민은 D2 수용체의 하향 조절 및 I형 인터페론의 상향 조절을 통해 시험관 내 SARS-CoV-2 복제를 감소시킵니다Article Published on 2022-05-192022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] administration affected Alter alteration Antiviral effect antiviral effects Calu Calu-3 Calu-3 cell line cell line correlation D2DR Dopamine doses downregulating downregulation epithelial Evidence expression Frame host cell IFN response IFNs immune response immune responses induce Inflammasome innate immune pathway innate immune pathways interferons Invasion ISG ISGs lung cells mechanisms mRNA NLRP3 NLRP3 inflammasome non-toxic occur pathway Pathways periphery pro-inflammatory mediators protein levels quinpirole quinpirole. recent receptor reduce reducing Replication robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication significantly turn upregulate viral replication while [DOI] 10.3390/cells11101691 PMC 바로가기 [Article Type] Article