Vaccination versus infection with SARS-CoV-2: Establishment of a high avidity IgG response versus incomplete avidity maturation백신 접종 대 SARS-CoV-2 감염: 높은 결합력 IgG 반응의 확립 대 불완전한 결합력 성숙Article Published on 2021-12-012022-09-12 Journal: Journal of medical virology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome avidity binding Complete coronavirus coronavirus disease COVID-19 defined domain epitope Epitopes facilitate IgG IgG response Immunity Immunoglobulin Incomplete individual induce Infection infection with SARS-CoV-2 initial maturation Messenger RNA mRNA naïve individual naïve individuals patients Prevent Protective protective immunity RBD Receptor-binding domain recomLine SARS-CoV-2 IgG SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individuals vaccination [DOI] 10.1002/jmv.27270 PMC 바로가기 [Article Type] Article
Probing Affinity, Avidity, Anticooperativity, and Competition in Antibody and Receptor Binding to the SARS-CoV-2 Spike by Single Particle Mass AnalysesResearch Article Published on 2021-11-042022-10-28 Journal: ACS Central Science [Category] COVID-19, [키워드] ACE2 binding ACE2 receptor affinity Analysis antibody arise avidity binding combating competition Complete complex complexes COVID-19 Critical determine Determining ectodomain Effect effective experiment Fabs glycosylated highlight IgG IgG antibodies Interaction interactions mass Neutralizing occur Particle Probing Protein Receptor binding reflected SARS-CoV-2 S SARS-CoV-2 spike spike steric the SARS-CoV-2 the SARS-CoV-2 virus trimeric utility [DOI] 10.1021/acscentsci.1c00804 PMC 바로가기 [Article Type] Research Article
Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Avidity Maturation and Association with Disease Severity중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 항체 결합력 성숙도 및 질병 중증도와의 연관성의 동역학Article Published on 2021-11-022022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome antibody Antibody avidity avidity coronavirus coronavirus 2 correlation COVID-19 disease IgG immunoassay Infection Kinetics label-free immunoassay maturation Mild peak respiratory SARS-CoV-2 significantly higher symptom onset thin-film interferometry. [DOI] 10.1093/cid/ciaa1389 PMC 바로가기 [Article Type] Article
Dynamics of IgG-avidity and antibody levels after Covid-19Covid-19 이후의 IgG 결합력 및 항체 수준의 역학Article Published on 2021-11-012022-09-11 Journal: Journal of Clinical Virology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] analysed Anti-nucleocapsid Anti-spike antibody antibody level antibody levels Antigen avidity binding blood sample Blood samples COVID-19 declining detectable Dynamics humoral immune response IgG Immunity increase in Infection levels of antibodies levels of antibody longitudinal cohort study majority maturation median median value median values Patient PCR-confirmed predict Prospective Reinfection risk RT-PCR SARS-CoV-2 severe COVID-19 significant decrease significant increase significantly significantly increased Viral viral infections [DOI] 10.1016/j.jcv.2021.104986 PMC 바로가기 [Article Type] Article
Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodiesCOVID-19 기증자 유래 중화 항체의 하위 집합에 의해 나타나는 사베코바이러스 전반에 걸친 광범위한 교차 반응성Article Published on 2021-09-282022-09-11 Journal: Cell Reports [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-RBD antibodies Anti-RBD antibody anti-SARS-CoV-2 antibody avidity binding site breadth CDRH3 changes class coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-reactivity crosslinking cryo cryo-EM Donor epitope Epitopes exhibited facilitate H-bond interaction neutralization Neutralizing Neutralizing antibodies neutralizing antibody occlude potent RBD RBD-binding antibody RBDs Receptor-binding domain recognize reducing respiratory reveal sarbecovirus SARS-CoV-2 SARS-CoV-2 variants sensitivity spike spike trimer Spike trimer: structural biology structural biology Structure subset trimer Vaccine design variants Viral viral spike Virology virology: X-ray crystallography. X-ray crystallography Zoonotic coronavirus zoonotic coronaviruses zoonotic sarbecovirus [DOI] 10.1016/j.celrep.2021.109760 PMC 바로가기 [Article Type] Article
Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations4가 SARS-CoV-2 중화 항체는 돌연변이 탈출에 대한 강화된 효능 및 내성을 보여줍니다Article Published on 2021-09-172022-09-11 Journal: Journal of Molecular Biology [Category] SARS, 변종, 진단, 치료제, [키워드] Anti-viral antibody antiviral therapies antiviral therapy approved avidity best binding site Bivalent COVID-19 drugs enhanced escape escape mutant host receptor Interaction magnitude mutants NAb NAbs Neutralizing Neutralizing antibodies potency produced promise Protein RBD-binding resistance S-protein SARS-CoV-2 show synthetic target tetravalent tetravalent. Therapeutics Threats Tolerance trimer variant Viral virus [DOI] 10.1016/j.jmb.2021.167177 PMC 바로가기 [Article Type] Article
Assessment of avidity related to IgG subclasses in SARS-CoV-2 Brazilian infected patientsSARS-COV-2 브라질 감염 환자의 IgG 서브 클래스와 관련된 열성 평가Clinical Trial Published on 2021-09-032022-08-13 Journal: Scientific Reports [Category] SARS, 임상, 진단, 치료기술, [키워드] analyzed anti-RBD Anti-RBD IgG anti-RBD IgG4 antibody Antibody avidity antibody levels Antibody Response Applied immunology assessment association avidity avidity range Brazil COVID-19 detectable Diagnostic markers died disease effort elicit ELISA exacerbated Follow-up form Health highlighting hospitalized patient hospitalized patients house IgG IgG antibody IgG subclasse IgG1 IgG3 IgG4 Immunological response Immunological techniques indicate infected patient Laboratory less life-threatening Mild Mild disease Most patients outcome Patient predict protective immunity RBD RBD IgG RBD IgG-ELISA RBD protein resulting reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD sensibility sera severe COVID-19 specificity study period symptomatic patient Symptomatic patients symptoms onset the disease Vaccine development with COVID-19 with mild disease [DOI] 10.1038/s41598-021-95045-z PMC 바로가기 [Article Type] Clinical Trial
Evaluation of Anti-PT Antibody Response after Pertussis Vaccination and Infection: The Importance of Both Quantity and Quality백일해 백신 접종 및 감염 후 항-PT 항체 반응 평가: 양과 질의 중요성Review Published on 2021-07-212024-07-28 Journal: Toxins [Category] 백일해, [키워드] antibodies avidity B cells CHO cell Epitopes Pertussis toxin [DOI] 10.3390/toxins13080508 PMC 바로가기 [Article Type] Review
Development of SARS-CoV-2 Specific IgG and Virus-Neutralizing Antibodies after Infection with Variants of Concern or VaccinationArticle Published on 2021-06-252022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] anti-N IgG Anti-RBD IgG anti-S IgG AstraZeneca avidity B.1.1.7 B.1.351 BNT162b2 ChAdOx1 concern contribute convalescent COVID-19 cVNT demonstrated detectable development domain Evidence examined humoral immune response Humoral immunity IgG immune response immunoblot Immunoglobulin increase in Infection Maturity Moderna mRNA-1273 neutralization Pfizer/BioNTech RBD reactivity robust SARS-CoV-2 SARS-COV-2 infection second dose sera Specific starting sVNT tested titer vaccination vaccine dose vaccinee vaccinees variants of concern viral spike virus variants virus-neutralizing antibodies virus-neutralizing antibody VoC was determined were used [DOI] 10.3390/vaccines9070700 PMC 바로가기 [Article Type] Article
Cross-Reactivity of Two SARS-CoV-2 Serological Assays in a Setting Where Malaria Is Endemic말라리아가 풍토병인 환경에서 두 SARS-CoV-2 혈청학적 분석의 교차 반응성Article Published on 2021-06-182022-09-11 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 말라리아, 진단, 치료법, [키워드] Abbott alleviate antibody Antibody binding Architect assays association avidity Concentration COVID-19 Critical cross-reactivity Endemic Euroimmun False positive False positives IgG IgG level indicated malaria moderate Nigeria PCR PCR-positive plasma Plasmodium Plasmodium falciparum Plasmodium falciparum infection positive Previous studies previous study Protein reduced SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 patient SARS-CoV-2 patients Serological assay serological assays serology setting significantly higher tested urea urea concentration urea concentrations was performed WASH [DOI] 10.1128/JCM.00514-21 PMC 바로가기 [Article Type] Article