Childhood Bacille Calmette-Guérin vaccination seems to selectively protect adult males from COVID-19 infectionArticle Published on 2022-04-012023-07-07 Journal: Allergy [Category] COVID19(2023년), [키워드] BCG COVID-19 SARS-CoV-2 Tuberculosis vaccination [DOI] 10.1111/all.15186 PMC 바로가기
Efficacy and Safety of BCG Revaccination With M. bovis BCG Moscow to Prevent COVID-19 Infection in Health Care Workers: A Randomized Phase II Clinical TrialClinical Trial Published on 2022-03-222022-10-05 Journal: Frontiers in Immunology [Category] 임상, [키워드] Activation approved Bacillus BCG carried children clinical clinical trial COVID-19 COVID-19 pandemic cross cross protection Efficacy Efficacy and safety eight HCW HCWs Health care worker IgM and IgG immune response IMPROVE incidence of COVID-19 individual induce innate response Mycobacterium bovis NK cell NK cells phase PROTECT protocol randomized-controlled Randomly ranged reducing Registered respiratory infection revaccination Safe Safety statistical significance Symptoms symptoms of COVID-19 the WHO Tuberculosis Vaccine viral infections [DOI] 10.3389/fimmu.2022.841868 PMC 바로가기 [Article Type] Clinical Trial
COVID-19 vaccine development based on recombinant viral and bacterial vector systems: combinatorial effect of adaptive and trained immunity재조합 바이러스 및 박테리아 벡터 시스템을 기반으로 한 COVID-19 백신 개발: 적응 및 훈련된 면역의 조합 효과Review Published on 2022-03-012022-09-11 Journal: Journal of microbiology (Seoul, Korea) [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive addition Antigen approach approval Bacteria Bacterial bacterial vector vaccine BCG cause cell-mediated immune response coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 infections COVID-19 pandemic COVID-19 vaccine COVID-19 vaccine development COVID-19 vaccines death Effect Efficacy Heterologous heterologous vaccine humoral immune responses immune responses Immunity induce Infection infections innate immune cell many case many cases memory MMR modulate polio Prevent PROTECT SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Severe acute respiratory syndrome trained immunity Vaccine vaccine candidate vaccine candidates Vaccines variants vector viral system Viral vector vaccine virus [DOI] 10.1007/s12275-022-1621-2 PMC 바로가기 [Article Type] Review
BCG-mediated protection against M. tuberculosis is sustained post-malaria infection independent of parasite virulencearticle Published on 2022-02-282024-09-01 Journal: Immunology [Category] 말라리아, [키워드] BCG malaria memory Mycobacterium Tuberculosis [Article Type] article
The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Pandemic: Are Africa’s Prevalence and Mortality Rates Relatively Low?Review Article Published on 2022-02-262022-10-28 Journal: Advances in Virology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome advanced age Affect African allelic variants BCG binding complex condition conditions Consequences coronavirus disease Coronavirus-2 COVID-19 deficiency disease disease severity Epidemiology exacerbate expression Factor Frequency Genetic predisposition genetic susceptibility genetics global pandemic Health host cell host cell receptor host tissue hypothese Immunity include Infection infection risk inhibitor Interaction involved lack less lung Lungs majority malaria Mortality mortality rate Occurrence other organ outcome pandemic Pathogenesis pathology Population populations Prevalence protease Protein Rate reported respiratory risk factor SARS-CoV-2 Spread structural protein subsequent subunit the disease thought TMPRSS2 vaccination virus [DOI] 10.1155/2022/3387784 PMC 바로가기 [Article Type] Review Article
Trained Immunity: An Overview and the Impact on COVID-19Immunology Published on 2022-02-172022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] activate alleviate approach B-glucan Bacillus BCG cell type cells clinical study clinical trials component Corona COVID-19 COVID-19 crisis COVID-19 pandemic develop disease pathogenesis effective greater Health immune immune protection immune response immune system Immunity Impact in vitro in vivo Infection Infectious disease innate immune cell innate immune system Innate immunity involved LPS mechanism monocyte Monocytes natural killer natural killer (NK) non-specific Pathogens pathway potential therapeutic target Protective respiratory SARS-CoV-2 SARS-COV-2 infection signaling pathway therapeutic target trained immunity understanding [DOI] 10.3389/fimmu.2022.837524 PMC 바로가기 [Article Type] Immunology
A Multi-Center, Randomised, Double-Blind, Placebo-Controlled Phase III Clinical Trial Evaluating the Impact of BCG Re-Vaccination on the Incidence and Severity of SARS-CoV-2 Infections among Symptomatic Healthcare Professionals during the COVID-19 Pandemic in Poland—First ResultsArticle Published on 2022-02-172022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 1:1 All participant Bacillus BCG BCG vaccination clinical clinical trial conducted control group coronavirus disease correlation country Course COVID-19 Diseases double-blind Evaluating Frequency Health care Health care worker hypothesised immune response Impact incidence incidence of COVID-19 introduced lack multicenter non-specific observation occurrence of COVID-19 pandemic phase Placebo placebo-controlled study Poland Prevent professional randomised reduce Research Result SARS-CoV-2 shown statistical analysis statistically significant stimulate Symptoms the disease Trial vaccination Vaccine Vaccines World Health Organization [DOI] 10.3390/vaccines10020314 PMC 바로가기 [Article Type] Article
Influence of Aerosol Delivered BCG Vaccination on Immunological and Disease Parameters Following SARS-CoV-2 Challenge in Rhesus Macaques히말라야 원숭이에서 SARS-CoV-2 감염 후 면역 및 질병 매개변수에 대한 에어로졸 전달 BCG 백신의 영향Immunology Published on 2022-02-092022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료제, [키워드] Activation acute respiratory syndrome adaptive aerosol Aerosol BCG vaccination antibody Antibody-mediated immunity antiviral immune response applied bacille Calmette-Guérin BAL BCG BCG vaccination Bronchoalveolar lavage cell-mediated immune response cellular challenge chemokine Classical CD14+ monocyte Classical CD14+ monocytes clearance collected comparable Concentration contribute coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 disease severity cross-protection cross-protective cross-reactive cytokine disease disease pathology disease severity early disease ENhance exceeded groups Heterologous High dose Histopathology Humoral immunity hypothesised immune cells immune mechanism immune response immune responses immune signature Immunity immunological parameters indicated induce Infection influence initial innate immune innate immune cell Innate immune cells Innate immunity Intervention intrabronchial intranasal macaque macaques marker mechanism Monocytes nasal nasal and pharyngeal swabs natural infection non-specific Occurrence parameter pharyngeal populations primary site priming quantified reduce respiratory respiratory pathogen rhesus macaque rhesus macaques SARS-CoV-2 secretion severe acute respiratory syndrome Coronavirus subsequent susceptible swabs T-cell T-cells the disease tissue tissue sample titre titres trained immunity Tuberculosis tuberculosis vaccine Vaccine Viral Viral RNA virus [DOI] 10.3389/fimmu.2021.801799 PMC 바로가기 [Article Type] Immunology
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challengeBCG의 정맥 투여는 치명적인 SARS-CoV-2 공격으로부터 마우스를 보호합니다Brief Definitive Report Published on 2022-02-072022-09-10 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] addition Administered alteration Analysis bacille Calmette-Guérin BCG BCG vaccination Cell cellular compartment clinically COVID-19 cytokine cytokine production Host immunopathology increase in Inflammatory inflammatory cell innate response intravenous Intravenous administration long-lasting mechanism mice Multivariate analysis myeloid cell nonspecific Pathogens pediatric phenomenon promote PROTECT provide pulmonary immune response recruitment reduced viral load reduced viral loads reducing reductions reductions in reported SARS-CoV-2 SARS-COV-2 infection subcutaneous route tissue pathology transgenic mice Tuberculosis vaccination variant Viral Viral load virus while [DOI] 10.1084/jem.20211862 PMC 바로가기 [Article Type] Brief Definitive Report
Is the BCG Vaccine an Answer to Future Pandemic Preparedness?Opinion Published on 2022-01-272022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome Antigen BCG bcg vaccine coronavirus COVID-19 Future health system Immunity implementation Intervention offer pandemic preparedness Pandemics pathogen Population PROTECT Safe SARS-CoV-2 vaccination Vaccine while [DOI] 10.3390/vaccines10020201 PMC 바로가기 [Article Type] Opinion