Time-Dependent Distribution of Hydroxychloroquine in Cynomolgus Macaques Using Population Pharmacokinetic Modeling MethodPharmacology Published on 2021-01-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] accumulated analyzed AUC biodistribution Blood Brain Clinical studies collected Concentration conducted Course cynomolgus macaque cynomolgus macaques decrease demonstrated descending described Determining distribution dosing regimen elimination rate constant euthanized evaluate faster fat group HCQ Hydroxychloroquine kidney liver lung lung tissue macaque modeling pharmacokinetic PK parameter plasma Population Population pharmacokinetics protein precipitation Quantitative receive red blood cells Result single dose spleen suggested time-dependent tissue tissues translation treatment regimen Urine Volume was determined [DOI] 10.3389/fphar.2020.602880 PMC 바로가기 [Article Type] Pharmacology
Slaying SARS-CoV-2 One (Single-domain) Antibody at a TimeReview article Published on 2020-12-172022-10-05 Journal: Trends in microbiology [Category] 비임상, [키워드] affinities antibody binding binding affinity biodistribution complex COVID-19 element highlight Immunoglobulin IMPROVE Novel coronavirus opinion Protein RBD SARS-CoV-2 Specificities spike target the receptor-binding domain the SARS-CoV-2 time yeast [DOI] 10.1016/j.tim.2020.12.006 [Article Type] Review article
Biodistribution and serologic response in SARS-CoV-2 induced ARDS: A cohort studySARS-CoV-2 유발 ARDS의 생체분포 및 혈청학적 반응: 코호트 연구Research Article Published on 2020-11-242022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 진단, 치료기술, [키워드] 30-Day mortality accompanied acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 antibody Antibody detection antibody formation Antiviral treatment ARDS binding domain biodistribution blood sample Blood samples Chain Reaction cohort study collected Concentration coronavirus COVID-19 detectable dialysate disease severity distribution enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay high viral load ICU treatment IgA antibodies IgA antibody IgM intensive care intensive care treatment investigated majority Most patient Most patients Neutralizing Neutralizing antibodies neutralizing antibody no difference non-survivor Non-survivors oropharyngeal swab oropharyngeal swabs Patient patients polymerase chain polymerase chain reaction positive Quantitative RBD remained respiratory respiratory distress Result retrospective reverse transcription reverse transcription quantitative polymerase chain reaction RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral load serologic Serologic response serologic testing severe acute respiratory syndrome Coronavirus severe ARDS severe corona virus disease significantly lower single-center study suffered survival survivor syndrome tested the patient tissue tracheal Tracheal aspirates Viral Viral load Virus Disease was performed [DOI] 10.1371/journal.pone.0242917 PMC 바로가기 [Article Type] Research Article
Repurposing chlorpromazine to treat COVID-19: The reCoVery studyResearch article Published on 2020-06-012022-10-05 Journal: L'Encéphale [Category] SARS, 신약개발, [키워드] alleviate Anti-SARS-CoV-2 Activity antiviral activity antiviral properties biodistribution blind Brain caused chlorpromazine Clathrin-mediated endocytosis clinical trial contagiousness Course COVID-19 COVID-19 infection COVID-19 pandemic CPZ developmental exhibit form France ICU care incidence individuals Infection lung multicenter neuroscience objective observation offer Paris Patient Prophylactic PROTECT psychotropic drug Randomized Recentin reduce reported repurposing Repurposing of molecules Respiratory Support Saliva SARS-CoV-2 severity Side effects standard treatment symptomatic therapeutic therapy Tolerance treat Trial virulent [DOI] 10.1016/j.encep.2020.05.006 [Article Type] Research article
Immunogenicity of a DNA vaccine candidate for COVID-19Article Published on 2020-05-202022-10-04 Journal: Nature Communications [Category] MERS, 치료기술, [키워드] ACE2 receptor antibodies antibody Antigen binding biodistribution build cellular immunity clinical study coronavirus Coronaviruses COVID-19 COVID-19 vaccine dataset disease dissemination DNA vaccine DNA vaccines expression functional generate identify immunization immunogenicity in vitro Infection initial INO-4800 Lungs MERS coronavirus mice neutralize Neutralizing antibody response pandemic Protein robust SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 vaccine spike Support T cell T cell responses the disease the S protein the SARS-CoV-2 translational Vaccine vaccine candidate Viral pneumonia [DOI] 10.1038/s41467-020-16505-0 PMC 바로가기 [Article Type] Article
Development and in vitro/in vivo evaluation of artemether and lumefantrine co-loaded nanoliposomes for parenteral deliveryarticle Published on 2019-03-312024-09-01 Journal: J Liposome Res [Category] 말라리아, [키워드] Artemisinin biodistribution combination therapy Hemolysis Histopathology malaria nanoliposomes [Article Type] article
Distribution and absence of generalized lesions in mice following single dose intramuscular inoculation of the vaccine candidate MVA-MERS-SArticle Published on 2018-07-062023-06-18 Journal: Biologicals : journal of the International Associa [Category] MERS, [키워드] biodistribution immunohistochemistry MERS PCR Poxvirus vaccine Vaccinia virus MVA Viral vector [DOI] 10.1016/j.biologicals.2018.05.004 PMC 바로가기 [Article Type] Article
Development of Adjuvanted Solid Fat Nanoemulsions for Pulmonary Hepatitis B VaccinationArticle Published on 2018-06-012023-06-18 Journal: Journal of pharmaceutical sciences [Category] B형 간염, [키워드] biodistribution deep lung delivery gamma scintigraphy IVIS imaging system solid fat nanoemulsions. [DOI] 10.1016/j.xphs.2018.02.007
Application of SPECT/CT imaging system and radiochemical analysis for investigation of blood kinetics and tissue distribution of radiolabeled plumbagin in healthy and Plasmodium berghei-infected micearticle Published on 2016-02-282024-09-01 Journal: Endocrine [Category] 말라리아, [키워드] biodistribution Plumbagin SPECT/CT imaging system Technetium-99m [Article Type] article
Alternative delivery of a thermostable inactivated polio vaccine열안정성 비활성화 폴리오 백신의 대체 전달 방법journal-article Published on 2015-04-012024-08-01 Journal: Vaccine [Category] 폴리오, [키워드] adjuvant biodistribution Bioneedles Needle free vaccine delivery [DOI] 10.1016/j.vaccine.2015.03.011 [Article Type] journal-article