Freeze-drying for the preservation of immunoengineering productsReview Published on 2022-09-132024-09-04 Journal: iScience [Category] 대상포진, [키워드] Biological sciences Biotechnology immunology [DOI] 10.1016/j.isci.2022.105127 PMC 바로가기 [Article Type] Review
Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variantsArticle Published on 2022-09-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] administration antibodies Antibody therapeutics Antiviral antiviral prophylaxis and therapeutics Biological sciences comparable conserved effective epitope fusion protein IgA IgG Fc Immunity infected with SARS-CoV-2 Infection intranasal invasive K18-ACE2 less Lineage mammalian Microbiology mucosal nanobody neutralization neutralize omicron Pichia pastoris produced Prophylactic Prophylaxis provide RBD recognize SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant severe respiratory disease Therapeutic treatment transgenic mice variant variants VoC [DOI] 10.3389/fimmu.2022.995412 PMC 바로가기
Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19Research article Published on 2022-06-172022-10-05 Journal: iScience [Category] 바이오마커, 임상, [키워드] Analysis Biological sciences Clinical finding Clinical outcome clinical outcomes collagen Concordance controls Coronavirus disease-19 COVID-19 COVID-19 disease severity COVID-19 patient cross talk disease global healthcare Hospitalized human metabolism immune modulation independent datasets Interaction Medicine metabolism metabolite metabolomic metabolomics molecular morbidity morbidity and mortality Mortality nucleotide outcome measure pandemic pathogenic performed Physiology predict predictive power Protein proteomic serum severe COVID-19 severe disease vascular homeostasis [DOI] 10.1016/j.isci.2022.104612 [Article Type] Research article
COH04S1 and beta sequence-modified vaccine protect hamsters from SARS-CoV-2 variantsArticle Published on 2022-06-172022-10-06 Journal: iScience [Category] 진단, [키워드] Beta Biological Biological sciences Candidates clinical investigation contagious COVID-19 COVID-19 vaccine cross-protective immunity cross-reactive antibody delta variant Efficacy elicit evade hamster healthy volunteers immunization immunogenic immunology Infection intramuscular Lower respiratory tract Lung pathology neutralizing antibody responses non-human primate nucleocapsid antigen PROTECT Protective response Safe SARS-CoV-2 SARS-CoV-2 variant Vaccine vaccine candidate Virology VoC weight loss Wuhan-Hu-1 [DOI] 10.1016/j.isci.2022.104457 PMC 바로가기 [Article Type] Article
Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodiesBrief Communication Published on 2021-11-292022-10-30 Journal: NPJ Vaccines [Category] COVID-19, [키워드] absence addition Antigen binding antibody Biological sciences correlated Critical detectable expressing immunization immunogenic induce Infectious diseases lung Lung inflammation mice Neutralizing antibodies neutralizing antibody S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine T-cell immunity T-cell Response the vaccine vaccination Vaccines Viral load [DOI] 10.1038/s41541-021-00405-5 PMC 바로가기 [Article Type] Brief Communication
Scientific rationale for developing potent RBD-based vaccines targeting COVID-19Review Article Published on 2021-10-282022-10-04 Journal: NPJ Vaccines [Category] 변종, 비임상, 임상, [키워드] addition Biological sciences Biomarker Cellular immune response COVID-19 cross-protective determinants domain dose full-length humoral immune response Infectious diseases natural infection neutralizing antibody non-inferiority offer pandemic PROTECT Protein RBD S-protein Safe SARS-CoV-2 spike the RBD vaccination Vaccine vaccine immunogen Vaccines variants of concern viral variant [DOI] 10.1038/s41541-021-00393-6 PMC 바로가기 [Article Type] Review Article
A Chinese host genetic study discovered IFNs and causality of laboratory traits on COVID-19 severityResearch article Published on 2021-10-012022-10-05 Journal: iScience [Category] 변종, 유전자 메커니즘, [키워드] Analysis association Biological sciences caused Chinese cholesterol clinical assessment comprehensive analysis contribute COVID-19 diagnosis COVID-19 pandemic COVID-19 severity current death disease disease severity explain functional gene gene-based analysis Genetic genetic mechanism genetic study genetics GSEA GWAS Host IFN Infection Innate immunity interferon Laboratory mendelian randomization MHC complex MR study Pathways Patient Receptor binding risk factor SARS Coronavirus traits Treatment type I interferon Virology WBC [DOI] 10.1016/j.isci.2021.103186 [Article Type] Research article
The nasal symbiont Staphylococcus species restricts the transcription of SARS-CoV-2 entry factors in human nasal epitheliumArticle Published on 2021-09-252022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract ACE2 angiotensin-converting enzyme 2 Biological Biological sciences cellular cellular receptor Complete Coronavirus-2 Evidence expressed Factor Host host protease Human indicate Invasion lung tissue Microbiology Molecular biology nasal nasal epithelium nasal mucosa reduce reduced reduction Regulation restrict SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 entry factor SARS-CoV-2 transmission significantly Staphylococcus symbiont TMPRSS2 Transcription transmembrane serine protease transmitted Virology [DOI] 10.1016/j.isci.2021.103172 PMC 바로가기 [Article Type] Article
Sensitive extraction-free SARS-CoV-2 RNA virus detection using a chelating resinArticle Published on 2021-08-092022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract Biological Biological sciences Biological sciences research methodologies buffer caused COVID-19 pandemic current Detection sensitivity diagnostic diagnostic test Direct initial lack Molecular Biology Experimental Approach Nasopharyngeal swab pathogen Patient PCR Quantitative Research reverse transcription PCR RNA RNA extraction RT-qPCR Safe SARS-CoV-2 SARS-CoV-2 RNA sensitive specimens supply shortage Swab Transport Treatment variety Viral transport medium Virology virus detection [DOI] 10.1016/j.isci.2021.102960 PMC 바로가기 [Article Type] Article
Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapyArticle Published on 2021-02-062022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract acute respiratory syndrome Analysis Biological Biological sciences Calu-3 coronavirus COVID-19 Disease progression elicited epithelial cell line epithelial cells expression gene expression profile Genes Heat shock host responses Hsp90 human cell line human cell lines identify IL-6 impair infected cell infected cells Infection inhibition inhibitor innate immune response interferon interferon regulatory factor knowledge Molecular biology NF-kB nuclear omics primary human airway pro-inflammatory cytokine pro-inflammatory gene Protein reduction RNA sequencing SARS-CoV SARS-CoV-2 subset suggested target gene Temporal therapy transcriptional activity transcriptomics upregulated viral replication Virology virus infection were expressed [DOI] 10.1016/j.isci.2021.102151 PMC 바로가기 [Article Type] Article