PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complexPRM1 및 KAR5는 세포-세포 융합 및 핵종에서 기능하여 Cryptococcus 병원성 종 복합체에서 뚜렷한 양성 및 단성 주기를 유도합니다Research Article Published on 2017-11-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence adaptation bisexual reproduction Cell Cell fusion cell-cell fusion cellular processe characterization characterized complex conserved Critical Cryptococcus Cryptococcus neoforman Cryptococcus neoformans de novo demonstrated diploid eukaryotic eukaryotic systems events Evolution forms fungal fungal pathogens fungi fusion protein generate Genetic genotypic hyphae hyphal independent individual involved isolate karyogamy mating type mechanism Morphological nuclear nuclear fusion nuclear membrane observation occur offset opposite organism ortholog orthologs pathogen pathogenic Pathogens pathway phenotypic diversity plants plasma membrane PRM1 produced regulate selfing sexual cycles sexual reproduction Sexuality similarities similarity Stage trajectory undergo yeast [DOI] 10.1371/journal.pgen.1007113 PMC 바로가기 [Article Type] Research Article
Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarateα-케토글루타레이트의 항상성 조절을 통한 Caulobacter crescentus의 트리카르복실산 회로와 펩티도글리칸 합성 간의 누화Research Article Published on 2017-08-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation addition Alter Antibiotics approach approaches Bacteria bacterial cell bacterial cells biosynthetic block blocks building by-product Caulobacter crescentus caused Cell cell wall cell wall synthesis cellular cellular metabolism cellular processe cellular processes central metabolism characterized classical conserved CRISPRi Crosstalk deletion mutant Disruption drug design energy generate genetics growth highlight homeostasis homeostatic inhibit interfere Interference master regulator metabolism metabolite metabolomics Morphological morphology mutant peptidoglycan phenotype precursors property Replication required resulting reveal robust susceptibility susceptible synthesis TCA cycle the cell transcriptomics tricarboxylic acid while [DOI] 10.1371/journal.pgen.1006978 PMC 바로가기 [Article Type] Research Article
PKA activity is essential for relieving the suppression of hyphal growth and appressorium formation by MoSfl1 in Magnaporthe oryzaePKA 활성은 Magnaporthe oryzae에서 MoSfl1에 의한 균사 성장 및 부착기 형성 억제를 완화하는 데 필수적입니다.Research Article Published on 2017-08-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation affinity Affinity purification Author C-terminal CAMP catalytic subunit cellular processe characterized co-IP conidia conidiation conserved Critical Deletion downstream eukaryotic cell eukaryotic cells Extracellular function functional functions Fusarium growth growth defect hyphal Infection insertion Interaction invasive involved IP assays loss-of-function mutation loss-of-function mutations Magnaporthe mutant mutants Mutation overlapping Pathogenesis pathway penetration Phosphorylation PKA produced purification reduced regulate regulated repressor residue response signaling pathway significantly strain Strains suppress suppressed suppression suppressor suppressors transcription factor transcriptional Treatment was reduced yeast [DOI] 10.1371/journal.pgen.1006954 PMC 바로가기 [Article Type] Research Article
A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease게놈 규모의 RNA-간섭 스크린은 헌팅턴병의 병리학적 특징으로 RRAS 신호를 식별합니다Research Article Published on 2012-11-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation addition Amino acid amino-terminus Analysis Author cascade caused Cell cellular cellular processe cellular processes component disease disorder Drosophila dysfunction effective ENCODE enzyme excitotoxicity farnesyltransferase FNTA found functional Glutamate Glutamine huntingtin Huntington's disease identify implicated in addition to increase in inhibitor Interaction Intervention involved Localization loss-of-function mammalian mechanism mechanisms mitochondrial mitochondrial dysfunction motor dysfunction mouse model mutant Mutation observé occur pathogenic pathway Pathways pharmacological PIN1 PLK1 Protein proteolysis RAF1 reduce reduced reducing repeated RNA interference RRAS Screen Signaling signaling pathway small molecule solubility suppress suppressed suppressor Therapeutic benefit These data Toxicity was performed [DOI] 10.1371/journal.pgen.1003042 PMC 바로가기 [Article Type] Research Article
Stimulation of Host Immune Defenses by a Small Molecule Protects C. elegans from Bacterial Infection작은 분자에 의한 숙주 면역 방어의 자극은 세균 감염으로부터 C. elegans를 보호합니다Research Article Published on 2012-06-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect analysis antibiotic Antibiotics ATF-7 Author Bacterial Bacterial infection Bacterial infections bacterial pathogen Bacterial pathogens Caenorhabditis elegan Caenorhabditis elegans cellular processe cellular processes Compound conserved effector molecule Efficacy elegan expression Gene Genes growth Host immune response host immunity identify immune immune regulators immunostimulatory Infection Interaction low molecular weight mechanism mechanism of action mode molecule molecules mutants nematode offer Pathogens pathway promote PROTECT Pseudomonas aeruginosa required small molecule Small molecules stimulate Stimulation tested therapy These data Transcription transcription factor Transcriptome Treatment variety [DOI] 10.1371/journal.pgen.1002733 PMC 바로가기 [Article Type] Research Article
Interactions of SARS Coronavirus Nucleocapsid Protein with the host cell proteasome subunit p42Research Published on 2010-05-172022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Analysis Cell cellular processe complex confocal microscopy coronavirus Critical detected diploid ENhance fetal fibroblast found fusion protein GST host cell host cells host protein immunofluorescence Inflammatory responses interact Interaction involved knowledge lung molecular mechanism nucleocapsid protein pathogenicity pathway Result SARS-CoV severe Spread subunit the mean variety [DOI] 10.1186/1743-422X-7-99 PMC 바로가기 [Article Type] Research