Event-Based Surveillance of Poisonings and Potentially Hazardous Exposures over 12 Months of the COVID-19 PandemicArticle Published on 2021-10-222022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] alcohol Border Canada changes in Chemical chlorine dioxide contributed COVID-19 COVID-19 infections COVID-19 pandemic death exposure facilitated function Government hand sanitiser hazard Hydroxychloroquine increasingly India International Ivermectin lockdown Measures media methanol misinformation MONITOR Month occurred PHE Poison poisoning Prevent provided Public public health Public Health England public health threat report reported service toxicovigilance treat [DOI] 10.3390/ijerph182111133 PMC 바로가기 [Article Type] Article
An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection기도 오르가노이드 기반 스크린은 SARS-CoV-2 감염에서 HIF1α-해당 축의 역할을 식별합니다Article Published on 2021-10-152022-09-11 Journal: Cell Reports [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] 2-furoic acid Abstract acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway airway organoid Alpha Analysis Anti-viral drugs B.1.351 block cells Chemical Compound coronavirus develop Disease model disease models dissect fatty Fatty acid fatty acid synthesis Genetic Glycolysis GW4671 high content drug screen hPSC-derived colonic organoid hPSC-derived colonic organoids human airway Human airway epithelium hypoxia hypoxia-inducible factor 1-alpha identify Infection inhibiting inhibitor mechanism metabolic MONITOR Organoid platform pluripotent stem cell respiratory reveal RNA sequencing RNA-Seq SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Screen severe acute respiratory syndrome Coronavirus stem cells subunit suppress Transcriptome Treatment xanthohumol [DOI] 10.1016/j.celrep.2021.109920 PMC 바로가기 [Article Type] Article
Optimizing Operating Parameters of Electric Ultra-Low Volume Sprayer with Slightly Acidic Electrolyzed Solution for Efficient Virucidal Activity on Environmental SurfacesArticle Published on 2021-09-282022-10-30 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] Acidic activity available chlorine Chemical chloride condition conditions Consensus correlation COVID-19 pandemic effective efficient healthcare human norovirus Infectious disease methodology Norovirus offer optimization parameter pathogenic PPM Prevent reduction in response surface methodology slightly acidic electrolyzed water solution spray disinfection Sprayer Spread statistical surface to define Transmission Treatment viral particle virucidal was performed [DOI] 10.3390/ijerph181910183 PMC 바로가기 [Article Type] Article
(−)-6-epi-Artemisinin, a Natural Stereoisomer of (+)-Artemisinin in the Opposite Enantiomeric Series, from the Endemic Madagascar Plant Saldinia proboscidea , an Atypical SourceArticle Published on 2021-09-122022-10-30 Journal: Molecules [Category] COVID-19, [키워드] Artemisia species Saldinia proboscidea antimalaria antiproliferative apoptosis induction Artemisinin Bioactivity biological properties Chemical Combination comparable Critical Endemic inhibitor inhibitory activity Isolation natural NMR opposite plant SARS-CoV-2 SARS-CoV-2 inhibitor Series Source Stereoisomer [DOI] 10.3390/molecules26185540 PMC 바로가기 [Article Type] Article
Phytochemicals from Leucas zeylanica Targeting Main Protease of SARS-CoV-2: Chemical Profiles, Molecular Docking, and Molecular Dynamics SimulationsArticle Published on 2021-08-172022-10-28 Journal: Biology [Category] COVID-19, [키워드] Leucas zeylanica acute respiratory syndrome addition Amino acid Analysis antiviral drug approach assist azetidin-2-one binding affinity binding pockets biological activity Candidates catalytic Characteristics Chemical complex complexes Compound compounds conserved coronavirus COVID-19 Cys145 dataset docked docking drug design Dynamics effective Effects Efficacy exhibited fluctuations gas chromatography–mass spectrometry GC-MS highest docking scores His41 Hydrogen bond impacted inhibitor inhibitors inhibitory activity Interaction Laboratory Leuca Ligand M pro main protease metabolite molecular molecular docking molecular docking analysis Molecular dynamics simulation phytochemical protease Protein protein sequence radius of gyration Research rigidity SARS-CoV-2 SARS-CoV-2 main protease simple Simulation stability targeting the SARS-CoV-2 therapeutic thermal stability Toxicity transmission rate vaccination variations was used were assessed were used [DOI] 10.3390/biology10080789 PMC 바로가기 [Article Type] Article
Anti-Viral and Immunomodulatory Properties of Propolis: Chemical Diversity, Pharmacological Properties, Preclinical and Clinical Applications, and In Silico Potential against SARS-CoV-2Review Published on 2021-07-312022-11-01 Journal: Foods [Category] COVID-19, [키워드] 3CL pro ACE2 acute respiratory syndrome addition amino acid residue angiotensin-converting enzyme 2 Anti-inflammatory anticancer antioxidant Antiviral antiviral properties binding affinity Characteristics Chemical chemical constituents clinical Clinical applications component coronavirus COVID-19 demonstrated derivative dietary supplement distribution Diversity drug-likeness effective Efficacy Helicase herpes simplex high affinity HIV HSV-1 Human immunodeficiency virus Hydrogen bond immunomodulatory influenza viruses measure metabolism modulating molecular docking Molecular docking study over Papain-like protease parameters pathogenic Pathways Potential Preclinical produced property Propolis protease RBD RdRP respiratory tract RNA-dependent RNA polymerase S-protein SARS-CoV-2 SARS-CoV-2 proteins shown Support target proteins the receptor-binding domain the spike protein therapeutic these compounds Toxicity viral entry virus viruses [DOI] 10.3390/foods10081776 PMC 바로가기 [Article Type] Review
Loop-Mediated Isothermal Amplification (LAMP): The Better Sibling of PCR?루프 매개 등온 증폭(LAMP): PCR의 더 나은 형제?Review Published on 2021-07-292022-09-11 Journal: Cells [Category] SARS, 진단, 치료기술, 치료제, [키워드] amplified Analysis Better Chemical conducted denaturation diagnostic DNA DNA polymerase Effectiveness eight faster highlight incubator isothermal amplification Japanese LAMP LAMP method less Loop-mediated isothermal amplification naked eye PCR primer Primers RNA RT-LAMP SARS-CoV-2 SARS-CoV-2 detection sibling targets temperature [DOI] 10.3390/cells10081931 PMC 바로가기 [Article Type] Review
First surveillance of SARS-CoV-2 and organic tracers in community wastewater during post lockdown in Chennai, South India: Methods, occurrence and concurrence인도 남부 첸나이에서 폐쇄 후 지역 사회 폐수에서 SARS-CoV-2 및 유기물 추적자의 첫 번째 감시: 방법, 발생 및 동시성Article Published on 2021-07-152022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] absence biochemical biochemical oxygen demand caffeine can be used Chain Reaction Chemical Chemical marker Chennai Clinical data collected Combination Community Concentration conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infected patients cycle cycle threshold dynamic range Efficiency enveloped virus Epidemiology filtration FIVE followed by hospital Indicator infected individual lockdown Occurrence oxygen oxygen demand pandemic plant polymerase chain reaction predicted proportion qRT-PCR Quantitative removal responsible RNA RNA copies SARS-CoV-2 sediment Sewage treatment Sludge solid phase South south India SPS SPSS study period supernatant Surveillance tendency threshold time interval Treatment Viral load virus wastewater wastewater based epidemiology [DOI] 10.1016/j.scitotenv.2021.146252 PMC 바로가기 [Article Type] Article
Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector–Host Interactions벡터 - 호스트 상호 작용을 조절하기 위해 아데노 바이러스 벡터의 유전자 및 화학 캡시드 변형Review Published on 2021-07-022022-09-10 Journal: Viruses [Category] SARS, 치료법, [키워드] Adenovirus capsid capsid modification cellular Chemical chemical modification classic component COVID-19 COVID-19 pandemic COVID-19 vaccine evade Gene therapy generate Genetic HPMA humans immune system Immunity induce Interaction Modification modulate modulated PEGylation pre-existing immunity Safe Vaccine vector vectors virotherapy widespread [DOI] 10.3390/v13071300 PMC 바로가기 [Article Type] Review
Toilet Paper, Minced Meat and Diabetes Medicines: Australian Panic Buying Induced by COVID-19Article Published on 2021-06-292022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] available data average Care categories Chemical COVID-19 COVID-19 pandemic declining diabete diabetes Government growth health behaviour Health services research health system impacted IMPROVE induced insulin management Medicine Non-communicable disease Number of prescription Pandemics paper Patient patients pharmaceutical prescription public health measure resulting routinely collected health data subsequent toilet Total was obtained [DOI] 10.3390/ijerph18136954 PMC 바로가기 [Article Type] Article