Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease
HIV-1 프로테아제의 약물 내성 관련 돌연변이 중 양성 상위성의 우세
Research Article
[키워드] alleviate
antiretroviral drug
antiretroviral drugs
Author
capture
clinic
clinical observation
clinical observations
Clinical studies
clinical study
clinically
Combination
combinations
compensatory mutations
deep sequencing
Deleterious
deleterious effect
deleterious effects
drug
drug resistance
Effect
epistasis
Evolution
fitness
Genetic
genetic interactions
greatly reduce
HIV
HIV-1
Impact
in vitro
inhibitors
Interaction
interactions
involved
likelihood
long term
majority
mechanism
mutant
Mutation
mutations
observation
outcome
overcome
pandemic
patients
persistence
positive
Prophylaxis
protease
Protease inhibitor
protease inhibitors
reduce
Replication
resistance mutations
reversal
reversion
selection experiments
sequence
Support
T cells
therapy
Viral
viral genome
viral replication
[DOI] 10.1371/journal.pgen.1009009 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1009009 PMC 바로가기 [Article Type] Research Article