Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19Review article Published on 2022-06-132022-10-05 Journal: The Lancet. Respiratory Medicine [Category] 바이오마커, 신약개발, 임상, [키워드] acutely ill patient Care clinical care clinical trials Clinical use clinically conducted COVID-19 detect disadvantage Effect Efficiency evaluate Hydroxychloroquine increasingly Intervention large sample Open-label Patient Pragmatic pragmatic trials question recommendation therapy treatment effects Trial UK RECOVERY trial Vaccines View widespread with COVID-19 [DOI] 10.1016/S2213-2600(22)00044-3 [Article Type] Review article
Thinking outside the box: non-canonical targets in multiple sclerosis Reviews Published on 2022-06-062022-10-05 Journal: Nature Reviews Drug Discovery [Category] 바이오마커, 신약개발, 치료제, [키워드] approach cause cellular Central nervous system Clinical use Coagulation Demyelination disease Disease progression exceptional FIVE future therapeutic highlight immune-mediated disease immunological Immunopathogenesis Immunotherapy incurable metabolite Multiple multiple sclerosis neurological recent Research resulting review target therapeutic option thinking Tolerance [DOI] 10.1038/s41573-022-00477-5 [Article Type] Reviews
Egg-Derived Anti-SARS-CoV-2 Immunoglobulin Y (IgY) With Broad Variant Activity as Intranasal Prophylaxis Against COVID-19COVID-19에 대한 비강내 예방으로서 광범위한 변이 활성을 갖는 계란 유래 항-SARS-CoV-2 면역글로불린 Y(IgY)Clinical Trial Published on 2022-06-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] 2019 novel coronavirus 2019-nCoV activity Administered Against Alpha anti-SARS-CoV-2 Antiviral approval approvals B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta binding capture chicken immunoglobulin clinical clinical trial clinical trial body Clinical use contagiousness Convalescent patients COVID-19 cross-reactivity Delta demonstrated develop Diseases distribution double-blind effective Emergency use authorization enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Evidence evidence of greater healthy human tissue human tissues IgY Immunity immunized Immunoglobulin immunoglobulin Y index Infectious diseases intranasal intranasally multiple dose multiple doses nasal drop nasal drops nasal mucosa neutralization titer no evidence of Novel coronavirus omicron Phase 1 phase 1 study Placebo placebo-controlled Prevalence Prophylaxis raised Randomized RATs RBD Receptor-binding domain reduce reduced risk Safe safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral sensitivity sera Spike protein the receptor-binding domain the SARS-CoV-2 Tolerability Transmission Trial Vaccine Vaccine hesitancy variants variants of concern variety Viral virus [DOI] 10.3389/fimmu.2022.899617 PMC 바로가기 [Article Type] Clinical Trial
Photodynamic disinfection of SARS-CoV-2 clinical samples using a methylene blue formulationArticle Published on 2022-06-012022-10-04 Journal: Photochemical & photobiological sciences : Official journal of the European [Category] COVID19(2023년), SARS, 신약개발, [키워드] amplification amplitude antimicrobial Antimicrobial photodynamic disinfection approved clinical sample Clinical use collected Concentration condition coronavirus disease COVID-19 COVID-19 patients cytotoxicity early stage exhibiting form global effort HEK293T cells infect Infection lentiviral luciferase reporter gene medical need Medicines Methylene Methylene blue nasal pandemic PDI photodisinfection photodynamic inactivation prevented pseudotyped Pseudotyped lentiviral vector reduce SARS-CoV-2 severity the disease the S protein Transmission Treatment urgency Viral load [DOI] 10.1007/s43630-022-00202-6 PMC 바로가기 [Article Type] Article
Dealing With Immunoglobulin Shortages: A Rationalization Plan From Evidence-Based and Data Collection면역글로불린 부족 처리: 증거 기반 및 데이터 수집의 합리화 계획Article Published on 2022-05-192022-09-12 Journal: Frontiers in Public Health [Category] MERS, 진단, [키워드] 95% CI addition analyzed Clinical management Clinical use close monitoring Collection coronavirus disease COVID-19 decrease demonstrated Effectiveness evaluate Evidence-based medicine Evolution IgG IgGs Immunoglobulin immunogolobulins indication information initial Intervention lack managing mean difference measure Measures occurred pandemic Patient performed plan public health public health system Rationalization real-world data Regional registry retrospective second shortages statistically Support the mean therapeutic Treatment was collected [DOI] 10.3389/fpubh.2022.893770 PMC 바로가기 [Article Type] Article
Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine stormFamotidine은 미주 신경 염증 반사를 활성화하여 사이토카인 폭풍을 약화시킵니다.Article Published on 2022-05-162022-09-11 Journal: Molecular Medicine [Category] 유전자 메커니즘, [키워드] Acetylcholine acetylcholine receptor activate Administered Alpha antagonist Anti-inflammatory anti-inflammatory activity anti-inflammatory effect Anti-inflammatory effects antiviral activity attenuate Blood brain barrier Brain cause Central nervous system characterized cholinergic Cholinergic anti-inflammatory pathway Cimetidine Clinical course Clinical studies clinical study Clinical use concentrations COVID-19 Cytokine storm disease dosage dosages Effect Evidence Famotidine Gastroesophageal reflux gastroesophageal reflux disease Genetic Histamine Histamine receptors ICV IL-6 Inflammatory inhibits inflammation knock-out lipopolysaccharide mast cell Mast cells mechanism mechanism of action mice morbidity and mortality Necrosis observation penetrate Prevent pro-inflammatory cytokine pro-inflammatory cytokine release Ranitidine recent receptor reduced released replicated serum severe COVID-19 Signal transduction Signaling significantly significantly more stimulated survival syndrome TNF treat Tumor tumor necrosis tumor necrosis factor vagus nerve Vagus nerve signaling. were assessed while α7nAChR [DOI] 10.1186/s10020-022-00483-8 PMC 바로가기 [Article Type] Article
A Novel Human Neutralizing mAb Recognizes Delta, Gamma and Omicron Variants of SARS-CoV-2 and Can Be Used in Combination with Sotrovimab새로운 인간 중화 mAb는 SARS-CoV-2의 델타, 감마 및 오미크론 변이체를 인식하고 소트로비맙과 함께 사용할 수 있습니다Article Published on 2022-05-162022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE-2 ACE-2 receptor angiotensin angiotensin converting enzyme anti-spike MAbs antibody Can Casirivimab caused Cell culture cell cultures cell entry Clinical use combinatorial treatment combinatorial treatments coronavirus Delta diagnostic drug ENhance epidemics/pandemics epitope Epitopes Gamma glycoprotein Human Imdevimab immune system Infection inhibitory effect Interaction interfere investigated mAb mAbs monoclonal monoclonal antibodies Neutralizing Neutralizing activity neutralizing mAbs. novel omicron Omicron variant pandemic Pandemics Patient RBD Receptor binding domain recognize recognizing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 virus Scientific community Sotrovimab spike spike glycoprotein Spike-RBD/ACE-2 subsequent the antibody the Spike therapeutic therapy variants virus virus infection [DOI] 10.3390/ijms23105556 PMC 바로가기 [Article Type] Article
Evaluation of Five Commercial SARS-CoV-2 Antigen Tests in a Clinical Setting임상 환경에서 5가지 상용 SARS-CoV-2 항원 테스트 평가Article Published on 2022-05-012022-09-11 Journal: Journal of General Internal Medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antigen antigen test antigen tests Chain Reaction Characteristics chemiluminescence immunoassay CLIA clinical clinical sensitivity Clinical use collected coronavirus COVID-19 Ct value cycle threshold evaluate evaluated female FIVE highest hospital independent infected individual infected individuals inverse correlation LIAISON Multivariate analysis nasopharyngeal NP swab NP swabs pandemic Patient PCR polymerase chain polymerase chain reaction ranged Rapid rapid antigen test rapid antigen testing. Rapid test RAT reference method reverse transcriptase Roche RT-PCR SARS-CoV-2 sensitivities sensitivity setting Sex swabs symptom onset Test was used [DOI] 10.1007/s11606-022-07448-x PMC 바로가기 [Article Type] Article
A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD Research Published on 2022-04-052022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, [키워드] activity acute respiratory syndrome approved B.1.617.2 binding caused circulating Clinical use coronavirus COVID-19 cryo-EM demonstrated Efficacy epitope form global pandemic Human monoclonal antibody in vitro in vivo mAb mAbs Microscopy molecular basis Mutation neutralize neutralizing monoclonal antibody novel coronavirus disease Prevent RBD reduced S trimer SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant the receptor-binding domain treat unique Vaccine variant VOCs wild-type [DOI] 10.1038/s41392-022-00954-8 [Article Type] Research
Cardiovascular Magnetic Resonance for Patients With COVID-19COVID-19 환자를 위한 심혈관 자기 공명Review Published on 2022-04-012022-09-11 Journal: JACC. Cardiovascular imaging [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Abnormalities abnormality Aneurysm cardiac function cardiovascular Cardiovascular Magnetic Resonance caused children Clinical use Coronary artery COVID-19 diagnostic dysfunction evaluate Evidence evidence of functional gadolinium Histopathology hospitalized patient hospitalized patients impairment Inflammation Inflammatory Ischemia Multiple studies multiple study Multisystem inflammatory syndrome Myocardial myocardial injury myocarditis noninvasive occur Patient patients patients with COVID-19 presenting raising recommendation recovering from COVID-19 reference standard reported Research resonance SARS-CoV-2 Symptom syndrome tissue [DOI] 10.1016/j.jcmg.2021.08.021 PMC 바로가기 [Article Type] Review