Syndromic surveillance: A key component of population health monitoring during the first wave of the COVID-19 outbreak in France, February-June 2020Research Article Published on 2022-02-102022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] age analysed association Characteristics coded coding collected contribute Course COVID-19 COVID-19 epidemic COVID-19 outbreak described diagnose epidemiological First wave France French Gender health monitoring hospitalisation hospitalised ICD-10 lockdown men MONITOR Older Patient Practitioner recommendation reliability reported representing Result robust SOS Surveillance were recorded women [DOI] 10.1371/journal.pone.0260150 PMC 바로가기 [Article Type] Research Article
Transcriptional landscape of circulating platelets from patients with COVID-19 reveals key subnetworks and regulators underlying SARS-CoV-2 infection: implications for immunothrombosisResearch Published on 2022-02-092022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] acute respiratory syndrome affected aggregation Analysis binding Cell circulating platelet Clinical outcome Coagulopathy coding coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 progression Critical eight energy metabolism feature healthy donors Hemostasis immune response immunothrombosis implication increased mortality Interaction involved mechanism molecular mechanism multiple organ failure Pathways patients with COVID-19 performed Platelet platelet activation Platelets promoted Protein provided regulate Result reveal risk RNA RNA Polymerase II RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease severity significantly subunit supplementary material therapeutic strategy thrombosis thrombotic complication thrombus formation transcription factor transcriptional Transcriptome upstream with COVID-19 [DOI] 10.1186/s13578-022-00750-5 PMC 바로가기 [Article Type] Research
Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicityArticle Published on 2022-02-082022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] alcohol antioxidant Apoptosis bone marrow failure Caenorhabditis elegan Cancer metabolism cause cellular cellular damage Chemical genetics coding contributing to crosslinking cytotoxicity DNA DNA damage DNA repair endogenous enzyme formaldehyde functional GSH human cell Mechanisms of disease metabolic pathways metabolite Mutation oxidative stress Patient prevented PROTECT question raising Redox imbalance reduced resulting syndrome Therapeutic benefit thiol group thought Toxicity Trigger underlie yielding [DOI] 10.1038/s41467-022-28242-7 PMC 바로가기 [Article Type] Article
From musk to body odor: Decoding olfaction through genetic variation사향에서 신체 냄새로 : 유전자 변이를 통해 후각을 해독하는Research Article Published on 2022-02-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation Amino acid amino acid substitutions androstenone Anosmia association Body odor change cis-3-hexen-1-ol coding contribute derived allele ENCODE example explicit functional Galaxolide Genetic genetic diversity Genetic variation Han Chinese human body Hypothesis implication IMPROVE individual information input intensity ionone mechanism musk novel association olfactory olfactory receptor OR4D6 OR51B2 OR5A1 OR7D4 Perception performed phenotype populations Previous studies provide receptor receptors reduced replicated reported robust second shown SNP SNPs trans Variation [DOI] 10.1371/journal.pgen.1009564 PMC 바로가기 [Article Type] Research Article
Impact of COVID-19 pandemic on ophthalmic presentations to an Australian outer metropolitan and rural emergency department: a retrospective comparative studyResearch Published on 2022-01-282022-10-28 Journal: BMC ophthalmology [Category] COVID-19, SARS, [키워드] analysed coding conducted COVID-19 COVID-19 pandemic demographics Diagnosis difference District emergency medicine Epidemiology First wave flexible Follow-up healthcare hospital Impact independent New ophthalmic Ophthalmic emergencies pandemic Patient care remained Result retrospective South supplementary material T-tests Tele-ophthalmology Triage were assessed [DOI] 10.1186/s12886-022-02271-8 PMC 바로가기 [Article Type] Research
Mutations in viral nucleocapsid protein and endoRNase are discovered to associate with COVID19 hospitalization risk바이러스 뉴클레오캡시드 단백질 및 endoRNase의 돌연변이가 COVID19 입원 위험과 관련이 있는 것으로 밝혀졌습니다Article Published on 2022-01-242022-09-10 Journal: Scientific Reports [Category] 변종, 유전자 메커니즘, 치료법, [키워드] Applying association change characterized clinical status coding Cohort Computational biology and bioinformatics correlation correlations COVID COVID-19 COVID-19 patient COVID19 Cytokine storms Diseases eight form functional genetics Haplotype Hospitalization IMPROVE in viral independent Inpatient inpatient status lead Molecular biology Non-synonymous nucleocapsid protein nucleotide occur Outpatient P -value peaked Protein q-values replicated residue residues risk SARS-CoV-2 selected sequenced severe COVID-19 significantly Single nucleotide variant SNV SNVs Spike protein state statistically significant synonymous the Spike Transmissibility triggering variant variants Viral viral genomes viral sequence viral sequences Viral variants Washington [DOI] 10.1038/s41598-021-04376-4 PMC 바로가기 [Article Type] Article
‘Us-Versus-Them’: Othering in COVID-19 public health behavior complianceResearch Article Published on 2022-01-242022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Affect Analysis analyzed applied coding Compliance COVID-19 COVID-19 pandemic Descriptive analysis female Gender group groups Health healthcare worker individual information lack Local objective Others participant Pragmatic public health Qualitative question Racial recommendations responses Result with COVID-19 [DOI] 10.1371/journal.pone.0261726 PMC 바로가기 [Article Type] Research Article
Viral and Host Genetic and Epigenetic Biomarkers Related to SARS-CoV-2 Cell Entry, Infection Rate, and Disease SeverityReview Published on 2022-01-232022-10-28 Journal: Biology [Category] COVID-19, [키워드] ACE2 receptor addition affecting Analysis binding Biomarker Biomarkers caused Cell Characteristics coding common contribute coronavirus Course COVID-19 COVID-19 susceptibility database Defense disease DNA methylation Epigenetic epigenetics epigenomic Evolution expression Factor feature gene silencing Genes Genetic genetic variability genetics genomic global pandemic help high mortality rate Host host cell host gene human gene immune system Infection inflammatory pathway interfere investigated mechanism miRNA molecular morbidity Mortality Mutagenesis Mutation new strain non-coding region Ontology outbreak outcome outcomes pathway performed Polymorphisms predict Predictive Prognosis prognostic biomarker Protein Rate Regulation Replication responsible RNA expression SARS-CoV-2 SARS-CoV-2 entry severity simple spread of COVID-19 Still susceptibility the disease the spike protein transcription factor Transmission Treatment Treatment response tumour suppressor viral entry viral genome Viral RNA virus virus–host interactions [DOI] 10.3390/biology11020178 PMC 바로가기 [Article Type] Review
Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study관찰 중개 연구에서 중환자 COVID-19 환자의 전신 염증 및 결과에 대한 IFIH1 rs1990760 변이체의 효과Research Article Published on 2022-01-212022-09-10 Journal: eLife [Category] 변종, [키워드] 95% CI 95% confidence interval analyzed Anti-inflammatory anti-inflammatory phenotype applied benefit Blood cause Cell changes in clinical trial clinical trials coding Cohort Concentration Corticosteroid corticosteroid treatment Corticosteroids COVID COVID-19 COVID-19 patient COVID-19 patients Critically ill death determine Dexamethasone discharge distribution drug Effect ENCODE experiment expression Factor funding Gene Expression greater hazard ratio healthy volunteer healthy volunteers help hospital host response Human ICU IFIH1 IL-6 IL6 immune Immune cell immune cells immune system Impact in-silico increase in individual Infection Inflammation Inflammatory response intensive care intensive care unit Laboratory less lower expression Lung injury MDA5 mechanical ventilation mediators moderate to severe modulate mononuclear cell mononuclear cells Mortality outcome outcomes Pathways Patient patients patients with moderate peripheral Peripheral blood Peripheral blood mononuclear cells pharmacogenomics physician populations pro-inflammatory mediators prospectively studied Protein recognize Red reduce regulate respond risk RNA serum Serum IL-6 severe COVID-19 Spain steroid Steroids supported survived systemic inflammation team the patient translational treat treated Treatment triggered variant variants Variation Viral viral infections virus viruses were measured [DOI] 10.7554/eLife.73012 PMC 바로가기 [Article Type] Research Article
Genomic surveillance of SARS-CoV-2 in the state of Delaware reveals tremendous genomic diversity델라웨어 주에서 SARS-COV-2의 게놈 감시는 엄청난 게놈 다양성을 보여줍니다.Research Article Published on 2022-01-192022-09-10 Journal: PLoS ONE [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha analyzed average B.1.1.7 B.1.351 B.1.429 B.1.617.2 Beta clade coding collected coronavirus Critical Delta Epsilon Gamma Genome genomic Genomic surveillance International international airports lineages location Mutation offer pangolin Perspective respiratory reveal SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains sequence sequenced Sequencing severe acute respiratory syndrome Coronavirus Spread strain Surveillance These data Transmission unique were used [DOI] 10.1371/journal.pone.0262573 PMC 바로가기 [Article Type] Research Article