Extension of Collagen Deposition in COVID-19 Post Mortem Lung Samples and Computed Tomography Analysis FindingsCOVID-19 사후 폐 샘플 및 컴퓨터 단층 촬영 분석 결과에서 콜라겐 침착의 확장Article Published on 2021-07-132022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, 치료기술, [키워드] 95% CI 95% confidence interval aeration Analysis analyzed collagen Computed tomography correlation correlations COVID-19 COVID-19 patient COVID-19 pneumonia Critically ill critically ill COVID-19 patients CT finding Deceased deposition detect extension fibrosis finding fixed formalin fraction histopathological Invasive mechanical ventilation investigated Lung CT Lung fibrosis median moderate paraffin patients with COVID-19 Pneumonia Postmortem Quantitative Radiographic Sample sensitivity Sirius specificity transbronchial [DOI] 10.3390/ijms22147498 PMC 바로가기 [Article Type] Article
Association Between COVID-19 Pregnant Women Symptoms Severity and Placental Morphologic FeaturesImmunology Published on 2021-05-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] accelerated age Analysis CD68 Cell change Clinical data collagen Comorbidities Comorbidity Control controls Course COVID-19 COVID-19 group death described evaluated feature fetal group immunohistochemistry infected with SARS-CoV-2 marker maternal age maturation Morphological morphometric analysis non-infected objective outcome pandemic Patient Placenta placental placental histopathology positive pregnant women Quantitative Red Result SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2–positive Sirius symptomatic symptomatic SARS-CoV-2 infection thrombosis Vascular vertical transmission vessels was performed women workshop [DOI] 10.3389/fimmu.2021.685919 PMC 바로가기 [Article Type] Immunology
Ultraviolet light-induced collagen degradation inhibits melanoma invasionArticle Published on 2021-05-122022-10-04 Journal: Nature Communications [Category] 변종, [키워드] arising Biomarker Cancer cancer cell Cancer microenvironment cancers Cell Col1a1 collagen contribute death Degradation degrade ECM expressing expression Extracellular matrix fibroblast Gene Expression Human IMPROVE incidence increase inhibit inhibiting Invasion invasive less Local Melanoma MMP1 modify outcome predictor Prognosis reduced reducing restored robust Single Cell survival Ultraviolet radiation [DOI] 10.1038/s41467-021-22953-z PMC 바로가기 [Article Type] Article
Human-Based Advanced in vitro Approaches to Investigate Lung Fibrosis and Pulmonary Effects of COVID-19Medicine Published on 2021-05-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] in vitro lung models acute respiratory distress affected alveolar alveolar epithelium alveolar regeneration ARDS assumed cause caused causing classical clinically collagen coronavirus coronavirus disease COVID-19 current DAD Diffuse alveolar damage disease ECM Effect Evidence Extracellular matrix fatal disease fibroblast in vitro in vitro model in vivo induce interstitial interstitial pulmonary fibrosis IPF knowledge lung Lung diseases Lung fibrosis lung organoids lung-on-chip mechanical stress molecular mechanism multicellular organoids Oxygenation pandemic Pathogenesis pathophysiological patients precision-cut lung slices proliferation Proteins pulmonary pulmonary fibrosis pulmonary impairment Pulmonary infection reduced respiratory SARS-CoV-2 SARS-COV-2 infection Symptoms syndrome tissue tissue regeneration treatment strategy Vaccine viral infections wound healing [DOI] 10.3389/fmed.2021.644678 PMC 바로가기 [Article Type] Medicine
A mechanism for matrikine regulation in acute inflammatory lung injury급성 염증성 폐 손상에서 마트리킨 조절 메커니즘Research Article Published on 2021-04-082022-09-12 Journal: JCI Insight [Category] MERS, 진단, [키워드] acetylated Acute inflammation acute lung injury airway epithelia animal animals BAL blockade Bronchoalveolar lavage cefadroxil chronic inflammatory disease clinical sample clinical samples coculture collagen competitive inhibitor Concentration COVID-19 Degradation determine Extracellular matrix extrapulmonary sites glycine in vitro in vivo Inflammation inflammatory lung injury inhibitor intratracheal intratracheal instillation knockdown knowledge LPS-induced lung injury lung Lung inflammation Lung injury lung tissue mechanism modulating mouse model neutrophil neutrophil chemoattractant Neutrophils Patient peptide peptides PGP potential therapeutic target proline redistribution reduced Regulation shown significantly Transport transported [DOI] 10.1172/jci.insight.140750 PMC 바로가기 [Article Type] Research Article
COVID-19 in a lung transplant recipient: Exploring the diagnostic role of circulating exosomes and the clinical impact of advanced immunosuppression폐 이식 환자의 COVID-19: 순환 엑소좀의 진단 역할 및 고급 면역 억제의 임상 영향 탐색Case Reports Published on 2021-04-012022-09-11 Journal: Transplant infectious disease : an official journa [Category] MERS, SARS, 진단, 치료기술, [키워드] Allograft allograft dysfunction Analysis antibodies Antigen cellular circulating exosome circulating exosomes clinical impact collagen COVID-19 detect diagnostic driven by dysfunction Exosome Exosomes female fluorescent intensity HLA HLA class II human leukocyte antigen Immunosuppression increase in Infection Injury leukocyte lung lung self antigens lung transplant mean fluorescent intensity Methylprednisolone Pathogens plasma recipient rejection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein self-antigen Spike protein Symptoms the mean the patient the SARS-CoV-2 treated tubulin Viral viral pathogens Viral protein Viral proteins [DOI] 10.1111/tid.13480 PMC 바로가기 [Article Type] Case Reports
D -Limonene Is a Potential Monoterpene to Inhibit PI3K/Akt/IKK-α/NF-κB p65 Signaling Pathway in Coronavirus Disease 2019 Pulmonary FibrosisMedicine Published on 2021-03-092022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] analyzed Angiogenesis binding collagen coronavirus disease Coronavirus disease 2019 coronavirus disease related pulmonary fibrosis COVID COVID-19 D-limonene database differentially expressed gene docked downloaded expression GeneCard Inflammatory response Lung fibrosis mechanism metabolism monoterpene NF-κB p65 pathway pharmacological Phosphorylation PI3K PI3K/Akt signaling pathway Potential Prevalence PROTECT Protein pulmonary pulmonary fibrosis reported Severe acute respiratory syndrome signaling pathway target targets therapeutic Treatment [DOI] 10.3389/fmed.2021.591830 PMC 바로가기 [Article Type] Medicine
IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infectionArticle Published on 2021-03-052022-10-04 Journal: Communications Biology [Category] SARS, 유전자 메커니즘, [키워드] characterized collagen Coronavirus disease 2019 COVID-19 COVID-19 disease disease downregulated IFN IFN signaling Immunopathogenesis IMPROVE increased mortality increasing age individuals with COVID-19 Infection innate immune pathway interferons lung Lungs macaque macaques neutrophil count neutrophil degranulation neutrophil lymphocyte ratio Notch Older overlap pathway poor prognosis reduced Regulation resulting rhesus risk factor SARS-COV-2 infection SARS-CoV-2 virus Signaling signaling pathway significantly transcriptional transcriptomic Tuberculosis Type upregulated viral infection [DOI] 10.1038/s42003-021-01829-4 PMC 바로가기 [Article Type] Article
sFasL—The Key to a Riddle: Immune Responses in Aging Lung and DiseaseReview Published on 2021-02-222022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, MERS, [키워드] aging association attack Autoimmune Autoimmune response Cell cell death cleaved collagen Control develop Diagnosis Evolution exacerbated expressing fibrosis full length Immune cell immune system Inflammation Inflammatory response inhibit involved key factor Ligand lung Lung disease Lungs mechanism membrane morbidity and mortality occur Organ failure pandemic persists pulmonary disease receptor regenerative Regulation response scar serum soluble Fas ligand subjects Surveillance survival T-cell the healthy tissue Treatment Tumor tumor cell tumor cells turn [DOI] 10.3390/ijms22042177 PMC 바로가기 [Article Type] Review
Autoimmune connective tissue diseases in the COVID-19 pandemic코로나19 팬데믹의 자가면역 결합조직 질환Review Published on 2021-01-012022-09-11 Journal: Clinics in dermatology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Antiviral appear arising Autoimmune clinical clinical entities clinical entity clinical trials collagen component concerning connective tissue disease Connective tissue diseases coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 therapy cytokine cytokine response disease elastin Elsevier explained expression Frequency heterogeneous group highlight hypercytokinemia immune response Immunosuppressed immunosuppressive immunosuppressive therapy Immunotherapy impairment Inc infections lymphohistiocytosis mechanism mechanisms modulate Most patients pandemic Patient patients physician problem problems respiratory severe acute respiratory syndrome Coronavirus severity susceptibility therapeutic option therapeutic options therapy treat Trial Viral viral infections [DOI] 10.1016/j.clindermatol.2020.12.013 PMC 바로가기 [Article Type] Review