Integration of whole genome sequencing and transcriptomics reveals a complex picture of the reestablishment of insecticide resistance in the major malaria vector Anopheles coluzzii전체 게놈 시퀀싱 및 전 사체의 통합은 주요 말라리아 벡터 Anopheles coluzzii에서 살충제 저항성의 재건에 대한 복잡한 그림을 보여줍니다.Research Article Published on 2021-12-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] alteration Anophele approach block change changes in colony complex complexity determine diagnostic Diagnostic markers elevated expression of gene Genetic genetic background Genome genomic genomic change increase in increased respiratory rate increasingly insecticide integration inversion Laboratory malaria malaria control malaria vector marker mechanism metabolism microbial Microbiome original oxidative phosphorylation pathway phenotype Population Pyrethroids respiratory rate reveal RNAseq Sequencing subject subset susceptible Transcriptome transcriptomic transcriptomics translated whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1009970 PMC 바로가기 [Article Type] Research Article
GraphOmics: an interactive platform to explore and integrate multi-omics data그래픽학 : 다중 생물 데이터를 탐색하고 통합하는 대화식 플랫폼Software Published on 2021-12-182022-09-10 Journal: BMC Bioinformatics [Category] 유전자 메커니즘, [키워드] Analysis biochemical can be used case study Clustering common reaction complex complexity computational method Data exploration dataset demonstrated difficulty examined filtered Fold changes heatmap hypothese Hypothesis information mapped metabolomics Omics integration p values pathway Pathway analysis Pathways performed platform proteomics reaction Reactions Reactome Result selected statistical significance Support transcriptomics user Visualisation was used while [DOI] 10.1186/s12859-021-04500-1 PMC 바로가기 [Article Type] Software
Testing Denmark: a Danish Nationwide Surveillance Study of COVID-19덴마크 테스트: COVID-19에 대한 덴마크 전국 감시 연구Research Article Published on 2021-12-152022-09-12 Journal: Microbiology Spectrum [Category] SARS, 진단, [키워드] 95% CI age associations can be used Care Community complexity contact with COVID-19 COVID-19 immunity determined by epidemiological epidemiological surveillance Face masks greater home care Households individuals infected individuals Infection information less Local National no difference participant Participants physical contact POCT population study positive PCR test Prevalence problem problems questionnaire Questionnaires Randomly Rapid test recommendation reported risk risk of infection risk ratio SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 infected individual SARS-CoV-2 infected individuals sensitivity seronegative participants seropositive Seropositivity Seroprevalence Stage Study design Surveillance Symptom Symptoms tested Testing vaccination was determined [DOI] 10.1128/Spectrum.01330-21 PMC 바로가기 [Article Type] Research Article
Rehabilitation needs following COVID-19: Five-month post-discharge clinical follow-up of individuals with concerning self-reported symptomsResearch article Published on 2021-12-052022-10-05 Journal: EClinicalMedicine [Category] 임상, [키워드] affective Analysis auditory breathlessness clinical examination clinically cognitive Cognitive function Cognitive impairment Cohort cohort study complexity concerning Consequences COVID-19 detrimental fatigue finding FIVE Follow-up form functional healthcare hospital hospitalised patient hospitalized COVID-19 patient individual Intervention Linköping Long-term follow-up nonspecific Östergötland PACS Pain Patient performed post-COVID-19 primary care problem provided Region regions rehabilitation Rehabilitation need reported required Residual symptoms SARS-CoV-2 self-reported symptom survivor Swedish Symptom Symptoms translated weakness were assessed [DOI] 10.1016/j.eclinm.2021.101219 [Article Type] Research article
Global Health Security Preparedness and Response: An Analysis of the Relationship between Joint External Evaluation Scores and COVID-19 Response Performance글로벌 보건 보안 대비 및 대응: 공동 외부 평가 점수와 COVID-19 대응 성과 간의 관계 분석Article Published on 2021-12-022022-09-11 Journal: BMJ Open [Category] SARS, 치료기술, [키워드] activate activities aligned analysed assessment tool Capacity center complexity concerning Concordance conducted Control coordination country COVID-19 COVID-19 pandemic detect Discordance disease control eight Emergency examined External finding generate global health global health security highest inclusion criteria independent lowest operation performance predict predicted Predictive Prevent prevention Probability public health relationship respond response score security Support Version were used [DOI] 10.1136/bmjopen-2021-050052 PMC 바로가기 [Article Type] Article
Optimal selection of monitoring sites in cities for SARS-CoV-2 surveillance in sewage networks하수도 네트워크에서 SARS-CoV-2 감시를 위한 도시의 모니터링 사이트 최적 선택Article Published on 2021-12-012022-09-11 Journal: Environment international [Category] SARS, 치료기술, [키워드] Algorithm Algorithms approach automatically case study complexity Coverage COVID-19 detect Epidemiology graph Graph theory greedy hot spot Iberian Peninsula identify Infection involved iteration iterations less minimum MONITOR overlapping Patient Probability reduce required SARS-CoV-2 SARS-CoV-2 surveillance second selected sensor Sensor placement sewage sewer Wastewater-based epidemiology [DOI] 10.1016/j.envint.2021.106768 PMC 바로가기 [Article Type] Article
Single-cell multi-omics sequencing: application trends, COVID-19, data analysis issues and prospects단일 세포 다중 오믹스 시퀀싱: 응용 동향, COVID-19, 데이터 분석 문제 및 전망Article Published on 2021-11-052022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] Analysis applied approaches bioinformatics Biotechnology Cell complex disease complex diseases complexity component COVID-19 COVID-19 pandemic Data analysis detect Diversity DNA DNA sequencing example genomic information graph graph-based algorithms heterogeneous Increasing individual individual cell individual cells information integrative methods machine learning mechanism Methylation multi pathway Pathways profile Protein question RNA sequence Sequencing Seurat Single Cell single-cell single-cell multi-omics sequencing single-cell sequencing tissue transfer variable variational inference. [DOI] 10.1093/bib/bbab229 PMC 바로가기 [Article Type] Article
Quality Management for Point-Of-Care Testing of Pathogen Nucleic Acids: Chinese Expert Consensus병원체 핵산의 현장 진료 테스트를 위한 품질 관리: 중국 전문가 합의Review Published on 2021-10-132022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 진단, 치료기술, [키워드] biosafety carried center Chain Reaction China Chinese clinical clinical laboratory clinics complementary complexity Consensus COVID-19 described Diagnosis division Economy emergency operations expert expert consensus Fever generate hospital implementation IMPROVE Infection Infectious disease Infectious diseases involved Laboratory management Medicine Microbiology Molecular diagnosis molecular diagnostics nucleic acid Nucleic acid detection pandemic pathogen Patient PCR performed physical platform POCT point-of-care point-of-care testing polymerase chain polymerase chain reaction presenting public health Quality Quality control reported Reporting required robust SARS-CoV-2 Shanghai Society Testing the epidemic whole-process operation management [DOI] 10.3389/fcimb.2021.755508 PMC 바로가기 [Article Type] Review
Harnessing recombinase polymerase amplification for rapid multi-gene detection of SARS-CoV-2 in resource-limited settings자원이 제한된 환경에서 SARS-CoV-2의 신속한 다중 유전자 검출을 위한 재조합효소 중합효소 증폭 활용Article Published on 2021-10-012022-09-11 Journal: Biosensors & bioelectronics [Category] SARS, 변종, 치료기술, 치료제, [키워드] amplification analytical sensitivity complementary complexity conserved COVID-19 pandemic demonstrated detect develop diagnostic diagnostic test diagnostic testing Dipstick E gene equipment faster Genes gold gold standard isothermal amplification Laboratory limit MERS-CoV molecular Molecular assay molecular test Multi-gene nucleic acid testing offer PCR platform point-of-care polymerase RdRP RdRp gene reaction Real-time detection REcombinase recombinase polymerase amplification reverse transcription RNA copies RNA copy SARS-CoV SARS-CoV-2 SARS-CoV-2 genes seasonal coronaviruses Sensitivity and specificity specificity Spread target variants of concern virus [DOI] 10.1016/j.bios.2021.113328 PMC 바로가기 [Article Type] Article
Proteases and variants: context matters for SARS-CoV-2 entry assays프로테아제 및 변이체: SARS-CoV-2 진입 분석에 대한 컨텍스트 문제Review Published on 2021-10-012022-09-11 Journal: Current opinion in virology [Category] SARS, 변종, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 arising cell line complexity coronavirus 2 dependent on driven by entry mechanisms flexible Humoral immunity implication in vivo other coronaviruses pathogenicity pathway priming protease Proteases Protein proteolytic proteolytic activation receptor respiratory SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus therapeutic efficacy tissue Transmission variant virus entry [DOI] 10.1016/j.coviro.2021.07.004 PMC 바로가기 [Article Type] Review