Entropy and Fractal Dimension Study of the TDP-43 Protein Low Complexity Domain Sequence in ALS Disease Severity and SARS-CoV-2 Gene Sequences in Virulence VariabilityArticle Published on 2021-08-122022-10-31 Journal: Information Sciences [Category] COVID-19, [키워드] ALS Amino acid Analysis Cell codon usage complexity computational analysis computational method conducted correlation coefficient cryo-EM defined described dimension domain Entropy extreme Fractal Fractal dimension gene sequence Genes HAR1 highest information low complexity domain sequence lowest nucleotide produced Protein protein sequence reported SARS-CoV-2 sequence TDP-43 Vaccine design viability virulence virulent Znf521 [DOI] 10.3390/e23081038 PMC 바로가기 [Article Type] Article
A computational analysis of molecular evolution for virulence genes of zoonotic novel coronavirus (COVID-19)Research article Published on 2021-08-012022-10-05 Journal: Computational biology and chemistry [Category] SARS, 변종, 유전자 메커니즘, [키워드] Adaptive molecular evolution Affect Amino acid Analysis coated computational analysis Coronaviridae family coronavirus disease COVID COVID-19 Diagnosis distribution Evolution genomic RNA hemagglutinin highly pathogenic homology Host Hypothesis Likelihood ratio test LRT Markov model Maximum likelihood MERS-CoV molecular motif Mutation Non-synonymous novel Novel coronavirus nucleocapsid protein nucleotide substitutions null hypothesis pandemic disease positive Positive selection Radiation Ratio RdRP reported respiratory tract selected silent single-stranded synonymous Test virulence gene virulence genes virus were used zoonotic [DOI] 10.1016/j.compbiolchem.2021.107532 [Article Type] Research article
Designing a multi-epitope vaccine candidate to combat MERS-CoV by employing an immunoinformatics approachArticle Published on 2021-07-292022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] addition allergenic antigenic approach approaches approved binding affinities can be used cause computational analysis computational approach Computational biology and bioinformatics Drug discovery effective Epitopes evaluated examined immune immune response Immune simulation immunoinformatics Interaction interactions lymphocyte MERS-CoV Middle East molecular docking Multi-epitope vaccine pathogen performed physicochemical profile respiratory syndrome coronavirus severe respiratory disease spike glycoprotein stability suggested T-cell target the vaccine thermodynamic TLRs Toll-like receptor triggering Vaccine vaccine candidate vaccine candidates [DOI] 10.1038/s41598-021-92176-1 PMC 바로가기 [Article Type] Article
Application of Big Data and Artificial Intelligence in COVID-19 Prevention, Diagnosis, Treatment and Management Decisions in ChinaSystems-Level Quality Improvement Published on 2021-07-242022-10-29 Journal: Journal of medical systems [Category] COVID-19, SARS, [키워드] accelerate acute respiratory syndrome affected application artificial artificial intelligence automatically big data caused China Clinical features close contact computational analysis contribute coronavirus COVID-19 COVID-19 pandemic decision deep learning Diagnosis Disease progression effective emergency response Epidemic epidemic prevention and control event explain feasible identify IMPROVE Infection Infectious disease information intelligence lack management mechanism outbreak populations prevention problem provide public health Research SARS-CoV-2 shown source of infection Spread Support Surveillance Transmission Treatment Vaccine Vaccine development Vaccines Wuhan, China [DOI] 10.1007/s10916-021-01757-0 PMC 바로가기 [Article Type] Systems-Level Quality Improvement
First comprehensive computational analysis of functional consequences of TMPRSS2 SNPs in susceptibility to SARS-CoV-2 among different populations다양한 인구 집단에서 SARS-CoV-2에 대한 감수성에서 TMPRSS2 SNP의 기능적 결과에 대한 최초의 포괄적인 계산 분석Article Published on 2021-07-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] 유전자 메커니즘, [키워드] Affect affected analyzed Antiviral antiviral drugs appearance Asian Asians Cell computational analysis current dbSNP de novo Donor donor site Effect ENCODE enhancer Ensembl Epigenetic ExPASY expression profile Frequency functional functional consequence Hypothesis in silico investigated KEGG mechanism miRNA miRNA profile miRNA profiles miRNAs Mortality motifs non-coding RNA Non-coding RNAs nucleotide PolyPhen-2 Population populations post-translational modification predict Protein protein folding PSIPRED retrieved SARS-CoV-2 SARS-CoV-2 cell SARS-CoV2 secondary structure Serine SIFT Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs splicing susceptibility susceptible therapeutic TMPRSS2 transmembrane serine protease were used [DOI] 10.1080/07391102.2020.1767690 PMC 바로가기 [Article Type] Article
Identification of SARS-CoV-2–induced pathways reveals drug repurposing strategiesResearch Article Published on 2021-06-302022-10-28 Journal: Science Advances [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Analysis approach approved drug approved drugs assays Cell clinical trials computational analysis coronavirus coronavirus disease COVID-19 datasets defined disease drug identification immune response implicated in viral Infection inhibit mechanism network analysis nine outbreak pathway Pathways predicted Protein Replication reveal SARS-CoV-2 shown sulfasalazine therapy Validity viral replication [DOI] 10.1126/sciadv.abh3032 PMC 바로가기 [Article Type] Research Article
A review on the interaction of nucleoside analogues with SARS-CoV-2 RNA dependent RNA polymerase뉴클레오사이드 유사체와 SARS-CoV-2 RNA 의존성 RNA 중합효소의 상호작용에 대한 고찰Review Published on 2021-06-302022-09-11 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, 치료제, [키워드] Antiviral antiviral drugs approved clinical development computational analysis CoV COVID-19 CoVs drug Efficacy ExoN ExoN proofreading Favipiravir human CoV human CoVs Infection information inhibitor Interaction lack nucleoside nucleoside analogue Nucleoside analogues outbreak platform preserved RdRP Remdesivir Repurposed drug ribavirin RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 RNA Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 sofosbuvir tenofovir Vaccine [DOI] 10.1016/j.ijbiomac.2021.03.112 PMC 바로가기 [Article Type] Review
Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients생식계열 IGHV3-53 인코딩 RBD 표적 중화 항체는 일반적으로 COVID-19 환자의 항체 레퍼토리에 존재합니다Research Article Published on 2021-06-062022-09-12 Journal: Emerging Microbes & Infections [Category] SARS, 진단, [키워드] ACE2 binding site activities antibody antibody repertoire antibody repertoire sequencing computational analysis conserved COVID-19 COVID-19 patient COVID-19 patients experiments generate germline heavy chain IGHV3-53 IGKV1-9 Laboratory mAb mAbs molecular MOST neutralizing antibody precursor Prevalence RBD RBD binding Receptor-binding domain recognize SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies sequence Sequencing shared clonotype Somatic hypermutation spike receptor-binding domain VH3-53 virus-neutralizing [DOI] 10.1080/22221751.2021.1925594 PMC 바로가기 [Article Type] Research Article
Molecular dynamics analysis of N-acetyl-D-glucosamine against specific SARS-CoV-2’s pathogenicity factorsResearch Article Published on 2021-05-272022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] 6M0J Analysis antibody bacterial cell binding carried computational analysis cough D614G domain ectodomain effective evade Factor Fever Host immune response immune system induce Infection inhibit manipulative MERS mimicking molecular molecular docking molecular docking analysis molecular dynamics mutant Mutation neutralizing antibody not affected nucleocapsid occurred pandemic pathogenicity performed Predictive protease Protein protein-ligand interaction Proteins Receptor binding domain responsible SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 S SARS-CoV-2 spike selected Severe case severe respiratory illness Shortness of breath shown Staphylococcus aureus supported Symptom temperature the SARS-CoV-2 virus trimer virus [DOI] 10.1371/journal.pone.0252571 PMC 바로가기 [Article Type] Research Article
Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infectionArticle Published on 2021-05-202022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] Alzheimer’s disease amino acids Analysis analyzed binding Blood Brain cerebrospinal fluid changes in Complication computational analysis Computational models Concentration Correlation analysis Data mining delirium Dementia determine distance docking enzyme Factor forest Infection influence MAOB metabolism metabolomic profiling Neural ageing neurological Neurological disorders Patient postoperative setting Protein risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein severe SARS-CoV-2 were used [DOI] 10.1038/s41598-021-90243-1 PMC 바로가기 [Article Type] Article