Natural experiment concept to accelerate the Re-purposing of existing therapeutics for Covid-19Research article Published on 2020-11-012022-10-05 Journal: Global Epidemiology [Category] 신약개발, [키워드] accelerate approach attributes candidate Clinical treatment clinical trials collected computational modeling diagnostic Disease progression distribution drug drugs Effect Epidemic epidemiological experiment group Infection Intensive limitation Mild molecular morbidity natural experiment normalized Novel coronavirus pandemic positive Prophylactic question resource SARS-COV-2 infection selected serologic antibody Surveillance test negative the patient therapeutic time-consuming Treatment [DOI] 10.1016/j.gloepi.2020.100026 [Article Type] Research article
Systems Biology Approaches for Therapeutics Development Against COVID-19COVID-19에 대한 치료제 개발을 위한 시스템 생물학 접근법Review Published on 2020-10-282022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료제, [키워드] Against approach Biology computational modeling coronavirus COVID-19 COVID-19 outbreak database (DB) development Factor Host host–virus interaction immunomics in silico multiomics Pathogenesis pathogenicity proteomics Research System Systems biology the vaccine therapeutic therapeutic drug therapeutic target therapeutic targets Therapeutics transcriptomics Treatment understanding virus [DOI] 10.3389/fcimb.2020.560240 PMC 바로가기 [Article Type] Review
Beta-Adrenergic Receptor Stimulation Modulates the Cellular Proarrhythmic Effects of Chloroquine and AzithromycinPhysiology Published on 2020-10-222022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] Activation Alter alteration analyzed antimalarial APD arrhythmia Arrhythmias autonomic Azithromycin beta-adrenergic canine cardiac electrophysiology changes in Chloroquine Combination computational modeling condition COVID-19 COVID-19 pandemic drug Effect Effects electrophysiology-basic exacerbated Extracellular Frequency in silico incidence Increasing inter-individual investigated isoproterenol limit occurred oxidative stress produced promoted reduced SARS-COV-2 infection Stimulation synergistic systemic inflammation therapeutic dose Variability ventricular [DOI] 10.3389/fphys.2020.587709 PMC 바로가기 [Article Type] Physiology
Building a PubMed knowledge graphData Descriptor Published on 2020-06-262022-10-04 Journal: Scientific Data [Category] 신약개발, [키워드] Abstract articles authors building classification Communication and replication computational modeling connection Data integration Data mining Deep Learning Method domain entity funding source information knowledge Metadata NIH ORCID organization PubMed abstracts reported resource significantly technology transfer [DOI] 10.1038/s41597-020-0543-2 PMC 바로가기 [Article Type] Data Descriptor
Investigation of Some Antiviral N -Heterocycles as COVID 19 Drug: Molecular Docking and DFT CalculationsArticle Published on 2020-05-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] 6LU7 Affect Amino acid amodiaquine approved atomic binding affinity binding energy Bioactivity calculation caused comparable computation computational modeling coronavirus COVID 19 COVID-19 Critical DFT calculations docked docking drug drug target drugs effective electrostatic evaluate evaluated functional Health highest Hydrogen bond hydrophobic interaction Hydroxychloroquine inhibitor investigated investigation M pro Medicines molecular molecular docking N-heterocycles Novel coronavirus nucleotide analogue pandemic parameter parameters performed polyprotein predicted protease Protein reactivity receptor Remdesivir residue SARS-CoV-2 SARS-CoV-2 main protease selected significantly Simulation study the binding affinity translated Viral RNA were used [DOI] 10.3390/ijms21113922 PMC 바로가기 [Article Type] Article
The Rise and Impact of COVID-19 in IndiaMedicine Published on 2020-05-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome affected Analysis computational modeling coronavirus coronavirus disease country COVID-19 Economy family Government Impact include India lockdown many case measure Ministry of Health Multiple outbreak pandemic positive protocol Quantitative raised reduce regions reported Safety measures SARS-CoV-2 Spread spread of COVID-19 spread to statistical Transmission Treatment virus Welfare Wuhan, China [DOI] 10.3389/fmed.2020.00250 PMC 바로가기 [Article Type] Medicine
School closure policies at municipality level for mitigating influenza spread: a model-based evaluationResearch Article Published on 2016-10-182023-05-24 Journal: BMC Infectious Diseases [Category] Fulltext, 신종인플루엔자, [키워드] computational modeling Influenza Mitigation Targeted school closure [DOI] 10.1186/s12879-016-1918-z PMC 바로가기 [Article Type] Research Article