Coordinated innate and T-cell immune responses in mild COVID-19 patients from household contacts of COVID-19 cases during the first pandemic wave첫 번째 대유행 기간 동안 COVID-19 사례의 가정 접촉에서 경미한 COVID-19 환자의 조정된 타고난 및 T 세포 면역 반응Article Published on 2022-07-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] absence Alpha anti-N antibodies anti-RBD antibody B-cell cell-mediated response Concordance Contact COVID-19 COVID-19 case COVID-19 cases Cycle threshold value cytokine detectable early immune response early immune responses ELISA enrolled evaluated Factor Follow-up greater high accuracy household household contact household contacts IFN-α IFN-γ IL-1ra IL-1β IL-9 immune responses immunofluorescence Immunopathogenesis indirect immunofluorescence individual innate response interferon interferon-alpha Interferon-alpha (IFN-α) Interferon-gamma Interferon-gamma (IFN-γ) release assay (IGRA) IP-10 MCP-1 membrane mild COVID-19 patient MIP-1β moderate Nasopharyngeal swab Neutralizing antibodies nucleocapsid pandemic peptide peptide pools plasma plasma samples positive positive swab Proteins RANTES RBD reported response returned RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 swab screened Seroconversion serological serological response significant negative correlation Spike protein stimulated subject Surveillance Swab Swab test swabs T-cell T-cell immune response T-cell Response T-cell specific virus Whole blood [DOI] 10.3389/fimmu.2022.920227 PMC 바로가기 [Article Type] Article
COVID-19 Variant Detection with a High-Fidelity CRISPR-Cas12 Enzyme고충실도 CRISPR-Cas12 효소를 사용한 COVID-19 변이체 탐지Article Published on 2022-07-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Analysis Assay validation circulating variant clinical sample clinical samples Concordance COVID-19 COVID-19 patient COVID-19 patients CRISPR CRISPR-Cas12 detection DETECTR Diagnostic method enzyme Enzymes faster followed by Genome sequencing guide RNAs identify infection control isothermal amplification L452R Laboratory test Laboratory tests LAMP Loop-mediated isothermal amplification Mutation mutations N501Y nucleotide omicron Patient polymorphism public health real-time RT-PCR RNAs SARS Coronavirus SARS coronavirus 2 SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant SARS-CoV-2 variants Sequencing single nucleotide Single nucleotide polymorphism SNP Surveillance target the SARS-CoV-2 Treatment treatment of COVID-19 patients utility variant variants Viral mutations viral mutations. whole-genome sequencing [DOI] 10.1128/jcm.00261-22 PMC 바로가기 [Article Type] Article
Real-time allelic assays of SARS-CoV-2 variants to enhance sewage surveillance하수 감시를 강화하기 위한 SARS-CoV-2 변이체의 실시간 대립유전자 분석Article Published on 2022-07-152022-09-11 Journal: Water research [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] allele Allele-specific RT-qPCR allelic Alpha Analysis Beta Beta variant clinically Community sewage Concordance COVID-19 patient cross-reactivity Delta delta variant diagnosed discharged eight ENhance Gamma genotypes Hong Kong integration Lambda offer omicron Omicron variant outbreak provided qPCR quarantine real-time RT-qPCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity sequence sewage Sewage surveillance specificity Surveillance variant variants Viral RNA whole-genome sequencing [DOI] 10.1016/j.watres.2022.118686 PMC 바로가기 [Article Type] Article
A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution Research Published on 2022-07-142022-10-05 Journal: Nature biomedical engineering [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome amplify Beta changes in cleavage colorimetric detection Concordance coronavirus diagnostic Evolution facilitate Gamma Mutation nucleic acid polymerase chain Quantitative Reactions RNA sequencing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants single-nucleotide Surveillance the SARS-CoV-2 thermodynamic throat swab urea variant Viral RNA virus [DOI] 10.1038/s41551-022-00907-0 [Article Type] Research
Performance evaluation of a non-invasive one-step multiplex RT-qPCR assay for detection of SARS-CoV-2 direct from saliva타액에서 직접 SARS-CoV-2 검출을 위한 비침습적 원스텝 멀티플렉스 RT-qPCR 분석의 성능 평가Article Published on 2022-07-072022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] accreditation administer approach bypasse bypasses Chain Reaction clinical settings Compliance Concordance criteria demonstrated diagnostic diagnostic testing evaluated followed by helping increased risk invasive medium multiplex RT-qPCR nasopharyngeal specimen Non-invasive overcome Patient PCR performance performed polymerase chain reaction protocol qPCR assay quantitative PCR reducing Regulatory resulting reverse transcription RNA extraction robust RT-qPCR Saliva saliva specimens sample collection SARS-CoV-2 SARS-CoV-2 detection sensitivity service Swab swabbing swabs Testing United Kingdom university [DOI] 10.1038/s41598-022-15616-6 PMC 바로가기 [Article Type] Article
A Path-Based Analysis of Infected Cell Line and COVID-19 Patient Transcriptome Reveals Novel Potential Targets and Drugs Against SARS-CoV-2감염된 세포주 및 COVID-19 환자 전사체의 경로 기반 분석을 통해 SARS-CoV-2에 대한 새로운 잠재적 표적 및 약물 공개Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ADCY2 ADSL Against anti-SARS-CoV-2 ATP bemcentinib biological network BUB1 Cell cell line cell lines central gene central genes changes Concordance conivaptan COVID-19 COVID-19 severity curated DEGs DEGs (Differentially Expressed Genes) Differentially expressed genes drug drugs targeting dysregulated e genes G1/S transition Genes greater identify Infection leukocyte leukocyte activation LINE metabolic process Migration MOST network analysis novel OCRL PBK PBMC PBMCs PBMCs (Peripheral Blood Mononuclear Cells) peripheral Peripheral blood Peripheral blood mononuclear cells phthalocyanine Potential reveal SARS-C0V-2 SARS-CoV-2 SARS-COV-2 infection severity target target gene TIAM1 Transcriptome transcriptomic viruses with COVID-19 [DOI] 10.3389/fimmu.2022.918817 PMC 바로가기 [Article Type] Article
Unraveling the hurdles of a large COVID-19 epidemiological investigation by viral genomics바이러스 유전체학으로 대규모 COVID-19 역학 조사의 장애물 풀기Article Published on 2022-07-012022-09-11 Journal: The Journal of Infection [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] assigned caused Community Concordance contribute COVID-19 COVID-19 case detect disease outbreaks Epidemics epidemiological Epidemiological investigation epidemiologically extension Genetic genetic profile genomic data Genomics Health authority healthcare information initial Local misidentification nursing home outbreak Portugal profiles Public public health public health authorities Region respiratory virus SARS-CoV-2 sensitivity Spread Still the disease Transmission Transmission dynamics triggered [DOI] 10.1016/j.jinf.2022.05.013 PMC 바로가기 [Article Type] Article
Detection and Stability of SARS-CoV-2 in Three Self-Collected Specimen Types: Flocked Midturbinate Swab (MTS) in Viral Transport Media, Foam MTS, and Saliva자체 수집한 3가지 표본 유형에서 SARS-CoV-2의 검출 및 안정성: 바이러스 수송 배지, 거품 MTS 및 타액의 무리를 이루는 중비갑개 면봉(MTS)Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ambient Analysis children cohorts collected Community Concordance conditions coronavirus COVID-19 detection evaluated exposure to facilitate feasible finding Foam illness illnesses in viral nucleocapsid Open reading frame ORF pandemic positive provided quantification reading respiratory respiratory specimens RT-PCR RT-PCR detection Saliva saliva samples saliva specimen saliva specimens sample collection SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA SARS-CoV-2 testing sensitivity severe acute respiratory syndrome Coronavirus specimen specimen collection spike stability Support Swab temperature tested Transport Transport media transported viral transport media VTM widespread [DOI] 10.1128/spectrum.01033-22 PMC 바로가기 [Article Type] Article
Evaluation of the Panbio COVID-19 Antigen Rapid Diagnostic Test in Subjects Infected with Omicron Using Different Specimens다양한 표본을 사용하여 오미크론에 감염된 피험자에서 Panbio COVID-19 항원 신속 진단 검사 평가Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Ag-RDT amplification Antigen B.1.1.529 Concordance coronavirus COVID-19 COVID-19 diagnosis COVID19 demonstrated Diagnosis diagnostic test Infection mutated nasal nasal swab nasal swabs nasopharyngeal sample Nasopharyngeal samples omicron Omicron variant oral oral swab oral swabs PanBio pandemic Patient PCR positive sample primary site Quantitative quantitative reverse transcription-PCR raised Rapid Rapid antigen tests Rapid diagnostic test Rapid test Replication reverse transcription-PCR RT-qPCR sample collection SARS-CoV-2 SARS-CoV-2 positivity sensitivity severe acute respiratory syndrome Coronavirus specimen symptomatic individuals Test tested Transmission variant VoC was performed was used [DOI] 10.1128/spectrum.01250-22 PMC 바로가기 [Article Type] Article
Evaluation of a commercial SARS-CoV-2 multiplex PCR genotyping assay for variant identification in resource-scarce settings자원이 부족한 환경에서 변이체 식별을 위한 상용 SARS-CoV-2 다중 PCR 유전자형 분석 평가Article Published on 2022-06-242022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African Analysis approaches Beta Beta variant beta variants characterization circulating circulating SARS-CoV-2 variant circulating variant circulating variants complement Concordance coronavirus COVID-19 Delta delta variant Delta variants demonstrated evaluated exhibited genomic sequencing genotyped genotyping globe gold gold standard multiplex Multiplex PCR offer omicron Omicron variant pathogenic variant PCR assay Real-time PCR real-time PCR assay reproducibility SARS-CoV-2 SARS-CoV-2 surveillance SARS-CoV-2 variant SARS-CoV-2 variants sensitivity South South Africa South Korea specificity specimen Spread Surveillance variant variants WGS whole genome Whole genome sequencing whole-genome sequencing [DOI] 10.1371/journal.pone.0269071 PMC 바로가기 [Article Type] Article