Single-cell sequencing of PBMC characterizes the altered transcriptomic landscape of classical monocytes in BNT162b2-induced myocarditisArticle Published on 2022-09-262022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome Affect Analysis AP-1 Biomarker BNT162b2 cell cluster changes changes in classical monocyte conditions conducted coronavirus Coronavirus - COVID-19 determine develop disease downregulation fatty acid metabolism Gene Expression identify include infiltration Kawasaki disease monocyte monocyte - macrophage Monocytes mononuclear cell mRNA vaccine myocarditis Pathogenesis Patient PBMC Peripheral blood proceed provides public health RNA RNA sequence SARS-CoV-2 SARS-COV-2 infection Sequencing single-cell Single-cell RNA sequencing subject the disease transcription factor Transcriptome transcriptome (RNA-seq) transcriptomic transcriptomic profile upregulation vaccination [DOI] 10.3389/fimmu.2022.979188 PMC 바로가기
Social Efficiency of Public Transportation Policy in Response to COVID-19: Model Development and Application to Intercity Buses in Seoul Metropolitan AreaArticle Published on 2022-09-232022-11-16 Journal: International Journal of Environmental Research an [Category] 변종, [키워드] addition Analysis application Area basic reproduction number conditions coronavirus disease COVID-19 development Effect Efficiency evaluate evaluated Fatality rate individual Infection intercity bus knowledge metropolitan area Model mutant number of infected passenger reduction policy Policy Probability Public Public transportation reduce reducing reduction required response social efficiency. Spread virus [DOI] 10.3390/ijerph191912060 PMC 바로가기
Correlation between Type I Interferon Associated Factors and COVID-19 SeverityArticle Published on 2022-09-192022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] acute respiratory syndrome Adaptive immune response Affect Antiviral antiviral response caused cells Chronic diseases conditions coronavirus COVID-19 COVID-19 severity declined dendritic cell dysfunction dysregulation early phase Factor Factors Frequency IFN IFN response IFN signature increased risk individual individual immune response inhibit magnitude Mild no symptoms Patient plasmacytoid dendritic cell plasmacytoid dendritic cell 1 Prevent produced producing promote response responsible risk risk factor SARS-CoV-2 severe coronavirus disease severe COVID-19 tissue damage Type type I Type I IFN type I IFNs type I interferon viral infection viral infections viral replication viruses [DOI] 10.3390/ijms231810968 PMC 바로가기
SARS-CoV-2 Production, Purification Methods and UV Inactivation for Proteomics and Structural StudiesArticle Published on 2022-09-082022-11-16 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome biosafety can be used cell activation conditions core Coronavirus-2 COVID-19 died downstream effective experiments faster handling inactivated inactivation Laboratory Microscopy pandemic pathogenicity Production purification resulting SARS-CoV-2 Sequencing Seven significantly size exclusion structural studies. sucrose cushion ultracentrifugation UV inactivation virus [DOI] 10.3390/v14091989 PMC 바로가기
SARS-CoV-2 infection in pediatric population before and during the Delta (B.1.617.2) and Omicron (B.1.1.529) variants eraArticle Published on 2022-09-082022-11-16 Journal: Virology Journal [Category] SARS, 변종, [키워드] Affect Asymptomatic available data B.1.1.529 B.1.617.2 caused children clinical manifestation clinical manifestations Complication conditions coronavirus disease country COVID-19 Delta delta variant Direct drastic exacerbating Google Scholar Health highest highlight Hospitalization immune response Immunodepressive incidence Infant Infants infected children Infection Manifestations Mild MIS MIS-C occur omicron Omicron variant pandemic pediatric Prevalence prevalence of COVID-19 proportion reported Risk factors SARS-COV-2 infection Science suggested symptomatic SARS-CoV-2 infection Symptoms the United State Transmission dynamics vaccination variant variants virulent [DOI] 10.1186/s12985-022-01873-4 PMC 바로가기
IL27 gene expression distinguishes multisystem inflammatory syndrome in children from febrile illness in a South African cohortArticle Published on 2022-09-062022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] African Anti-inflammatory Antiviral change children clinically Cohort condition conditions Control controls COVID-19 cytokine differential expression differentially expressed gene down-regulated gene expression febrile febrile illness Follow-up Gene Expression healthy healthy children healthy controls highlight IL-27 IL27 immune gene immune-related gene Inflammatory inflammatory condition inflammatory conditions inflammatory reaction innate immune pathway innate immune system investigated Kawasaki disease lack longitudinal MIS-C Multisystem inflammatory syndrome Other pathway Patient pyroptosis quantitative PCR resolved SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity South South Africa specimen syndrome systemic lupus erythematosus timepoints Treatment two group unique up-regulated was determined [DOI] 10.3389/fimmu.2022.992022 PMC 바로가기
Immunomolecular assay based on selective virion capture by spike antibody and viral nucleic acid amplification for detecting intact SARS-CoV-2 particlesArticle Published on 2022-09-052022-11-15 Journal: Journal of Nanobiotechnology [Category] SARS, 치료기술, [키워드] Accuracy acute respiratory syndrome aluminum amplification analyses antibody applied Characteristics clinical sample coefficient Complete Complete virions conditions convalescent coronavirus coronavirus disease COVID-19 Critical detect diagnose facilitate Factor glycoprotein Human immunodeficiency virus human serum Immune escape Immunomolecular detection IMPROVE infection risk Influenza isolation rooms limit of detection molecular monoclonal antibody Mutation nucleic acid amplification Outbreaks parameters Patient pseudovirus quantified Quantitative reduced reverse transcription PCR reverse transcription-PCR SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 pseudovirus selective specific antibodies spike stability Vaccine Variation Viral load viral nucleic acid viral spike viral titer virion virions virus virus detection virus isolation viruses [DOI] 10.1186/s12951-022-01558-8 PMC 바로가기
Age and product dependent vaccine effectiveness against SARS-CoV-2 infection and hospitalisation among adults in Norway: a national cohort study, July-November 2021Article Published on 2022-09-022022-11-16 Journal: BMC Medicine [Category] SARS, 변종, [키워드] adjusted Admissions age AZD1222 BNT162b2 booster Care change changes in Cohort studies cohort study Combination Comorbidities conditions confidence interval country covariate COVID-19 COVID-19 vaccine COVID-19 vaccines death delta variant dominant dose effective Effectiveness facilitated groups hazard heterologous schedules highest hospitalisation hospitalisations Hospitalization Infection intensive care intensive care units knowledge Mortality mRNA mRNA-1273 National Norway pandemic population-based cohort proportional hazards models provided receiving regimen regimens registries remained SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections second dose Sex Support the vaccine vaccination Vaccine vaccine dose vaccine effectiveness waned [DOI] 10.1186/s12916-022-02480-4 PMC 바로가기
Rapid repeat infection of SARS-CoV-2 by two highly distinct delta-lineage viruses2개의 매우 구별되는 델타 계통 바이러스에 의한 SARS-CoV-2의 빠른 반복 감염Case Reports Published on 2022-09-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid amino acid substitutions change conditions Deletion deletions Delta delta variant genomic had no Health increasingly individual Infection Lineage mutations Patient positive Protective Protein question Rapid Reinfection SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants singular Spike protein the Spike variant virus [DOI] 10.1016/j.diagmicrobio.2022.115747 PMC 바로가기 [Article Type] Case Reports
SARS-CoV-2 infects human cardiomyocytes promoted by inflammation and oxidative stressSARS-CoV-2는 염증과 산화 스트레스에 의해 촉진되는 인간 심근세포를 감염시킵니다Article Published on 2022-09-012022-09-12 Journal: International journal of cardiology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accounted acute respiratory syndrome analysed antiviral intervention Apoptosis apoptotic cardiac damage Cardiomyocytes cell damage cells change co-morbidities condition conditions COVID-19 patient Cytokine storm Donor driven by heart Heart damage heart failure infect Inflammation Inflammatory involved marker mechanism Myocardial non-infected oxidative stress Patient pro-inflammatory promote promoted protease provide Respiratory illness SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 infected patient target tissue triggered ventricular viral entry virus entry [DOI] 10.1016/j.ijcard.2022.05.055 PMC 바로가기 [Article Type] Article