Monitoring of the SARS-CoV-2 Omicron BA.1/BA.2 lineage transition in the Swedish population reveals increased viral RNA levels in BA.2 casesArticle Published on 2022-09-092022-11-16 Journal: Med (New York, N.Y.) [Category] SARS, 변종, [키워드] airway analyzed BA.1 BA.2 CDC collected contagious COVID-19 cases dominant feasibility help Lineage monitoring nasopharyngeal occurred omicron pandemic populations reliability reveal RT-PCR RT-PCR assay SARS-CoV-2 Swedish the SARS-CoV-2 Translation to population health Transmissibility unique upper airways variant variants of concern Viral load Viral RNA [DOI] 10.1016/j.medj.2022.07.007 PMC 바로가기
Network Pharmacology and Bioinformatics Analysis Identifies Potential Therapeutic Targets of Paxlovid Against LUAD/COVID-19Article Published on 2022-09-082022-11-16 Journal: Frontiers in Endocrinology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Against Analysis approved bioinformatics caused Clinical characteristics Clinical data contagious coronavirus Coronavirus disease 2019 correlation country COVID-19 COX Cytoscape downloaded drug drug target DrugBank evaluate evaluated Fatality rate FDA Features food functional Gene Expression GeneCards Genes GO enrichment analysis IL-17 IL12B IL6 include infected with COVID-19 Interaction KEGG LBP lung adenocarcinoma (LUAD) lung cancer patient management mechanism modulate molecular molecular docking Mortality NCBI network network pharmacology pandemic pathway Pathway analysis Patient Paxlovid Pharmacology Potential potential therapeutic target Prognosis prognostic receptor Regression model risk SARS-CoV-2 screened signaling pathway survival rate susceptibility SwissTargetPrediction target target gene TargetNet therapeutic target Transcriptome Treatment Venn diagram virus was performed was used while [DOI] 10.3389/fendo.2022.935906 PMC 바로가기
Platinum nanoparticles (PtNPs)-based CRISPR/Cas12a platform for detection of nucleic acid and protein in clinical samplesArticle Published on 2022-09-082022-11-15 Journal: Analytica chimica acta [Category] SARS, 치료기술, [키워드] acute respiratory syndrome Antigen Biomarker Biomarkers biosensor clinical sample Concentration contagious coronavirus CRISPR/Cas12a detect Detection sensitivity diagnostic Diseases identify N gene Noble metal nanocatalysts nucleic acid Nucleic acid detection optical platform Platinum Protein Protein detection Quantitative reduction reported Research RT-qPCR SARS-CoV-2 sensitivity specificity specimens [DOI] 10.1016/j.aca.2022.340203 PMC 바로가기
A universal SARS-CoV DNA vaccine inducing highly cross-reactive neutralizing antibodies and T cellsArticle Published on 2022-09-022022-11-15 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 바이오마커, 변종, 비임상, 진단, [키워드] antibody Beta contagious cross-reactive Delta DNA vaccine domain evade functional Human human ACE2 receptor Immunity induce lethal disease lethal infection membrane mice neutralized neutralizing antibody New observation omicron pandemic priming PROTECT Protective SARS-CoV SARS-CoV vaccine SARS-CoV-2 Spike protein T cell T cells the SARS-CoV-2 Vaccine Vaccine development Vaccines variant variants virus WHO [DOI] 10.15252/emmm.202215821 PMC 바로가기
Exploring the risk factors of COVID-19 Delta variant in the United States based on Bayesian spatio-temporal analysisArticle Published on 2022-09-012022-11-16 Journal: Transboundary and emerging diseases [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis Bayesian Bayesian analysis Cluster coefficient collected contagious contribute coronavirus covariate COVID-19 COVID-19 variant cases delta variant develop Effect Epidemic Factor flexible genetic mutation Government group help heterogeneity Hierarchical identify independent variables measure Region risk factor Risk factors SARS-CoV-2 selected space-time model spatial clusters Spread statistical the United State Transmission variable selection variant worsened [DOI] 10.1111/tbed.14623 PMC 바로가기
Role of Breath Biopsy in COVID-19Article Published on 2022-09-012022-11-15 Journal: The journal of applied laboratory medicine [Category] 바이오마커, [키워드] affected Analysis approach biochemical Biomarker Biomarkers biopsy breath breath analyzers caused contagious country Coverage COVID-19 COVID-19 diagnosis diagnosis of COVID-19 healthcare mass spectrometry noninvasive reproducibility Respiratory disease role SARS-CoV-2 sensitivity specificity transmitted VOCs [DOI] 10.1093/jalm/jfac040 PMC 바로가기
Vaccine effectiveness against SARS-CoV-2 infection or COVID-19 hospitalization with the Alpha, Delta, or Omicron SARS-CoV-2 variant: A nationwide Danish cohort studyArticle Published on 2022-09-012022-11-16 Journal: PLoS Medicine [Category] SARS, 변종, [키워드] 95% confidence interval age Alpha variant Analysis BNT162b2 mRNA calculated CIs cohort study Comorbidity contagious coronavirus 2 COVID-19 COVID-19 hospitalization Delta delta variant Denmark dose doses Effectiveness estimate geographical region group groups Hospitalization Infection mRNA-1273 nonrandomized study Occurrence omicron provided Regression model respiratory SARS-CoV-2 SARS-COV-2 infection Sex short-lived sustained the vaccine uninfected unique vaccinated individuals vaccination Vaccination Status vaccine dose variant variants waned waning immunity was obtained was used [DOI] 10.1371/journal.pmed.1003992 PMC 바로가기
Integrated bioinformatics-cheminformatics approach toward locating pseudo-potential antiviral marine alkaloids against SARS-CoV-2-MproSARS-CoV-2-Mpro에 대한 유사 잠재적 항바이러스 해양 알칼로이드를 찾기 위한 통합 생물정보학-화학정보학 접근Article Published on 2022-09-012022-09-11 Journal: Proteins [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 added Alpha analyzed Antiviral antiviral marine alkaloids approach ATB AutoDock B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta binding energy candidate carried complex complexes contagious Coronavirus-2 darunavir docking docking study drug drug-likeness drug-likeness profiles prediction Entropy enzyme exhibit free energy H-bond highest Initially investigated Ligand literature review Lopinavir lowest MD simulation MM/PBSA molecular molecular docking molecular docking simulation molecular dynamics Molecular mechanics Molecular Orbital morbidity morbidity and mortality MPro omicron pharmacokinetics pharmacological physicochemical predicted profile profiles protease Protein Protein Data Bank retrieved RMSD RMSF SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease selected Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2-Mpro. surface area thermodynamic Topology Toxicity variants Virtual screening were assessed were recorded [DOI] 10.1002/prot.26341 PMC 바로가기 [Article Type] Article
Rapid Control of Hospital-Based Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Clusters Through Daily Testing and Universal Use of N95 RespiratorsN95 호흡기의 일상적인 테스트와 보편적인 사용을 통한 병원 기반 중증 급성 호흡기 증후군 코로나바이러스 2오미크론 클러스터의 신속한 제어Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Admission Cluster Clusters contagious Control coronavirus coronavirus 2 Daily increase increases in Infection N95 respirator nosocomial Nosocomial infection Nosocomial transmission omicron Omicron variant Prevent Rapid Respirator respiratory risk SARS-CoV-2 Symptom Testing Transmission transmissions Universal variant [DOI] 10.1093/cid/ciac113 PMC 바로가기 [Article Type] Article
Surface charge changes in spike RBD mutations of SARS-CoV-2 and its variant strains alter the virus evasiveness via HSPGs: A review and mechanistic hypothesisArticle Published on 2022-08-242022-11-16 Journal: Frontiers in Public Health [Category] SARS, 변종, 유전자 메커니즘, [키워드] Affect Alter antibodies antibody binding binding affinity calculated cells change changes changes in Characteristics complexes contagious COVID-19 pandemic distribution docking domain drug design electrostatic electrostatic interaction ENhance entry of SARS-CoV-2 epitope hACE2 HSPGs human Angiotensin-converting enzyme hypothese Hypothesis immune evasion Invasion involved molecular mechanism mutant Mutation mutations neutralizing antibody occurred omicron pathophysiological Point mutation positive Protein Proteoglycan RBD RBD mutation RBD mutations residue S protein S trimer SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 variants strain surface the RBD Therapies Vaccine development variant variant strain viral fitness viral infectivity virulence virus virus receptor [DOI] 10.3389/fpubh.2022.952916 PMC 바로가기