Reduced mortality in COVID-19 patients treated with colchicine: Results from a retrospective, observational study콜히친으로 치료받은 COVID-19 환자의 사망률 감소: 후향적 관찰 연구 결과Observational Study Published on 2021-03-242022-08-13 Journal: PLoS ONE [Category] Biochemistry, SARS, 임상, [키워드] 7-point ordinary scale accelerated adjusted adjusted hazard ratio association C-reactive protein Clinical improvement Colchicine colchicine group control group control patient control patients coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CT scan cumulative mortality diarrhea Hospitalized implicated IMPROVE Inflammatory marker inflammatory markers Inflammatory response linear lymphocyte Lymphocyte count Mortality neutrophil Neutrophil-to-lymphocyte ratio objective occurred outpatients pathway patients Pneumonia Probability proinflammatory pulmonary complications Randomized controlled trial rationale receive reduce reduced Result retrospective retrospective cohort study Retrospective study Side effect skin rashes Support supported survival the patient treated Treatment two groups Weighting [DOI] 10.1371/journal.pone.0248276 PMC 바로가기 [Article Type] Observational Study
The Potential of Developing Pan-Coronaviral Antibodies to Spike Peptides in Convalescent COVID-19 Patients회복기 COVID-19 환자의 펩티드 급증을 위한 범 코로나바이러스 항체 개발의 가능성Article Published on 2021-03-062022-09-12 Journal: Archivum immunologiae et therapiae experimentalis [Category] SARS, 진단, [키워드] antibodies bind binding Blood cell entry cellular receptor collected collected data control group control patients convalescent COVID-19 patient Coronaviral coronavirus COVID-19 COVID-9 Cross reactivity cross-reactive antibody cross-reactivity decrease described Developing domain effective ELISA help heptad repeat hidden homology IgG antibody immunogenic immunoglobulins Infection infections inhibitory membrane membrane fusion MERS-CoV Middle East non-infected opposite peptide polyclonal antibody Population Potential presence of antibody raise reactivity recognize respiratory syndrome coronavirus S1 subunit S2 subunit SARS-CoV-2 SARS-COV-2 infection sera seropositive severity similarity spike Spike protein tested the spike protein Vaccine Viral mutations were used [DOI] 10.1007/s00005-021-00607-8 PMC 바로가기 [Article Type] Article
The Nucleocapsid protein triggers the main humoral immune response in COVID-19 patients뉴클레오캡시드 단백질은 COVID-19 환자의 주요 체액성 면역 반응을 유발합니다Article Published on 2021-03-052022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 진단, 치료기술, 치료법, [키워드] addition Amino acid amino acids Antibody Response caused control patient control patients coronavirus COVID-19 COVID-19 antibody COVID-19 pandemic COVID-19 patient COVID-19 patients detect develop dot blot Epitopes fragment full length generate help humoral immune response identify IgG antibody immune immune response immunoreactivity Immunotest infected patient infected patients M protein membrane membrane protein MOST N protein nucleocapsid nucleocapsid protein other coronaviruses Patient positive positive immune response Protein S protein SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection selectivity spike Spike protein the N protein the S protein Trigger Vaccine Vaccine development Viral viral particle virus [DOI] 10.1016/j.bbrc.2021.01.073 PMC 바로가기 [Article Type] Article
Remdesivir and systemic corticosteroids for the treatment of COVID-19: A Bayesian re-analysisResearch article Published on 2021-03-012022-10-05 Journal: International Journal of Infectious Diseases [Category] SARS, 치료법, [키워드] approach Bayesian Bayesian meta-analysis Bayesian re-analysis calculated clinical trial clinically Clinicians control patients coronavirus disease Corticosteroid Corticosteroids COVID-19 death decrease Dexamethasone Evidence exceeded help hospitalized patient Interpretation measure mechanical ventilation Meta-analysis Mortality objective outcome Oxygen requirements oxygen support participant Patient performed Posterior Probability quantified random effect reduction in mortality Remdesivir Result subgroup supplemental oxygen systemic corticosteroid systemic corticosteroids Treatment while with COVID-19 World Health Organization [DOI] 10.1016/j.ijid.2021.01.065 [Article Type] Research article
Efficacy and safety of favipiravir, an oral RNA-dependent RNA polymerase inhibitor, in mild-to-moderate COVID-19: A randomized, comparative, open-label, multicenter, phase 3 clinical trialClinical Trial Published on 2021-02-012022-10-05 Journal: International Journal of Infectious Diseases [Category] SARS, 임상, [키워드] 1:1 Adverse Antiviral Asymptomatic clinical trial control patients coronavirus coronavirus disease COVID-19 died disease Efficacy and safety event Favipiravir inhibitor lack limitation median time Mild-to-moderate multicenter Open-label Patient Phase 3 phase 3 trial primary endpoint Randomized randomized clinical trial RNA-dependent RNA polymerase RT-PCR RT-PCR assay SARS-CoV-2 Significant standard supportive care statistical significance supportive care Symptom the primary endpoint viral shedding worsening [DOI] 10.1016/j.ijid.2020.11.142 PMC 바로가기 [Article Type] Clinical Trial
Association between high-dose steroid therapy, respiratory function, and time to discharge in patients with COVID-19: Cohort study고용량 스테로이드 요법, 호흡 기능, COVID-19 환자의 퇴원 시간 사이의 연관성: 코호트 연구Observational Study Published on 2021-01-082022-09-11 Journal: Medicina clínica [Category] 바이오마커, 임상, [키워드] adjusted Analysis association Cohort cohorts control patients coronavirus COVID-19 Cox multivariate model Cox multivariate models Cox regression Dexametasona Dexamethasone discharge doses Evolution glucocorticoid Glucocorticoides Glucocorticoids hazard ratio High-dose hospital increment log-rank Methylprednisolone Metilprednisolona multivariate no significant difference observational study oxygen Patient patients hospitalized patients treated Primary outcomes Prognostic factors Respiratory function SAFI SARS-CoV-2 significant difference significantly Spain sub-cohort therapy Treatment treatments for COVID-19 with COVID-19 [DOI] 10.1016/j.medcli.2020.08.003 PMC 바로가기 [Article Type] Observational Study
Hemoperfusion with CytoSorb as Adjuvant Therapy in Critically Ill Patients with SARS-CoV2 PneumoniaSARS-CoV2 폐렴이 있는 중환자에서 보조 요법으로 CytoSorb를 사용한 혈액관류Observational Study Published on 2021-01-012022-09-11 Journal: Blood purification [Category] SARS, 임상, 진단, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome adjuvant adjuvant therapy Anticoagulant Antiviral approved ARDS Blood Blood purification C-reactive protein cartridge Case report Clinical course Clinical outcome conducted consecutive patient Continuous Positive Airway Pressure control patient control patients coronavirus coronavirus 2 coronavirus disease Course COVID COVID-19 COVID-19 patients Critical illness Critical illness cytokines Cytokines Cytosorb develop diagnosed died Effectiveness effector Evidence greater Hemoperfusion Hospital admission Hospitalized IL-10 IL-6 IL-8 Ill IMPROVE include Inflammation inflammatory state intensive care unit Intubated intubation limited sample size lymphocytopenia Measures mechanism medical emergency observational study oxygen oxygen supplementation pathogenic Patient patients Pneumonia positive airway pressure randomized clinical trial remained required respiratory respiratory distress Respiratory function respiratory specimens reverse transcription-PCR SARS-CoV2 scenario sequence severe acute respiratory distress syndrome Severe acute respiratory syndrome severe pneumonia Study design survived syndrome therapeutic therapeutic strategy therapy tissue injury TNF-α treated treated patient treated patients Treatment virus worsened [DOI] 10.1159/000511725 PMC 바로가기 [Article Type] Observational Study
Development and Validation of an Automated Radiomic CT Signature for Detecting COVID-19Article Published on 2020-12-302022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Accuracy artificial intelligence AUC automated characteristic Chest computed tomography clinical condition Computed tomography confirmed case control patient control patients coronavirus disease COVID COVID-19 COVID-19 infection COVID-19 patient dataset development Diagnosis False negative False positives feature Health Healthcare system help implementation independent Intervention Isolation limits machine learning measure Negative predictive value NPV outbreak pandemic status Patient patients Positive predictive value PPV Radiomics reached RT-PCR sensitivity signature social distancing specificity test dataset threshold validation volumetric was used [DOI] 10.3390/diagnostics11010041 PMC 바로가기 [Article Type] Article
Dynamics of NK, CD8 and Tfh cell mediated the production of cytokines and antiviral antibodies in Chinese patients with moderate COVID‐19NK, CD8 및 Tfh 세포의 역학은 중등도 COVID-19 환자에서 사이토카인 및 항바이러스 항체 생성을 매개합니다Original Article Published on 2020-11-032022-09-12 Journal: Journal of Cellular and Molecular Medicine [Category] MERS, SARS, 진단, [키워드] abnormal increase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed antibody antiviral antibody B‐cell benefit caused CD226 CD4 CD8 Cell cell count cellular change Chinese patient contribute control patient control patients convalescent convalescent patient coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 cytokine cytokine level cytokine levels Cytokines decrease demonstrated Dynamics effector effector memory electrochemiluminescence immunoassay enrolled expression flow cytometry iCoS immune responses increase in Inflammatory cytokine Inflammatory cytokines inhibitory innate immune response lymphocyte maintenance memory moderate NK NK cell NK cells Patient patients with moderate peripheral lymphocyte Pneumonia Prevent recent respiratory RT‐PCR SARS‐CoV‐2 SARS‐CoV‐2‐specific antibodies SARS‐CoV‐2‐specific antibody severe acute respiratory syndrome Coronavirus Severe case severe cases significantly higher significantly increased subset T cell T cells T‐cell Tfh TIM‐3 [DOI] 10.1111/jcmm.16044 PMC 바로가기 [Article Type] Original Article
Assessment of Chloroquine and Hydroxychloroquine Safety Profiles: A Systematic Review and Meta-AnalysisPharmacology Published on 2020-10-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 2019 coronavirus disease 95% confidence interval adverse event adverse events AEs Affect Analysis Antiviral assessment Chloroquine control patients Controlled COVID-19 COVID-19 patient COVID-19 patients dosage drug estimate evaluated exhibited four group HCQ Hydroxychloroquine immunomodulatory inclusion criteria involved limit measure medication medications Meta-analysis Mild neurologic OSF other diseases outcomes participant patients performed Placebo random-effect Randomized controlled trial RCT RCTs Registered Registration Result review risk Risk of bias Safety safety profile safety profiles searched significantly higher subgroup analysis suggested treat Treatment Trial unlikely were used [DOI] 10.3389/fphar.2020.562777 PMC 바로가기 [Article Type] Pharmacology