Pancreatic Injury after COVID-19 Vaccine—A Case ReportCase Report Published on 2021-06-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] abdominal pain adverse effect caused Characteristics clinical close monitoring Comirnaty coronavirus vaccine COVID-19 COVID-19 mRNA vaccine COVID-19 pandemic Critical death described Efficacy Injury mRNA vaccine occurred pancreatic Pancreatic Injury Pancreatitis pandemic participant Patient Pfizer report reported Symptom Trial vaccination Vaccine [DOI] 10.3390/vaccines9060576 PMC 바로가기 [Article Type] Case Report
PPAR agonists as effective adjuvants for COVID-19 vaccines, by modifying immunogenetics: a review of literatureReview Published on 2021-05-312022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] Abstract adjuvant agonist anti-apoptotic antibody Antigen boost coronavirus vaccine COVID-19 infection COVID-19 vaccine COVID-19 vaccines debatable Effect effective Factor fatty acid oxidation immune immune system Immunologic memory Immunological memory IMPROVE increasingly Interaction long-lived plasma cell mechanisms memory metabolism pandemic PD-L1 peroxisome persistence PPAR Re-infection receptor secretion Seroconversion stimulated switching T cell T cell memory T memory cells T regulatory cells the vaccine upregulating vaccination Vaccine [DOI] 10.1186/s43141-021-00179-2 PMC 바로가기 [Article Type] Review
Potential adverse events in Japanese women who received tozinameran (BNT162b2, Pfizer-BioNTech)Commentary Published on 2021-05-312022-10-29 Journal: Journal of Pharmaceutical Policy and Practice [Category] COVID-19, [키워드] administration adverse event Analysis aspiration pneumonia association benefit BNT162b2 cardiovascular disease causal link cause coronavirus vaccine death died event FIVE hemorrhage Hemorrhagic ICH incidence incompatible Japan Japanese men men and women mortality data Pfizer-BioNTech raised regulatory authority report reported reveal Statistics stroke the vaccine thrombosis venous women [DOI] 10.1186/s40545-021-00326-7 PMC 바로가기 [Article Type] Commentary
Killed whole-genome reduced-bacteria surface-expressed coronavirus fusion peptide vaccines protect against disease in a porcine model죽은 전체 게놈 감소 박테리아 표면 발현 코로나 바이러스 융합 펩티드 백신은 돼지 모델에서 질병으로부터 보호합니다423 Published on 2021-05-042022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 진단, [키워드] Amino acid amino acid residues anamnestic response Bacteria Bacterial Betacoronavirus Cell cell surface clinical disease conserved core coronavirus coronavirus disease Coronavirus disease 2019 coronavirus vaccine COVID-19 cross-protection demonstrated diarrhea disease downstream Efficacy elicited ENhance epidemic diarrhea Escherichia coli evaluated Express expressing expression vector fusion peptide genome-reduced bacteria vaccine platform highly conserved fusion peptide immune system Immunity Interaction interferon interferon-γ offer pandemic Pathogens PEDV peptide PIGS platform porcine epidemic diarrhea virus (PEDV) principle proof PROTECT Protective provide provided reduced residue responses SARS-CoV-2 sequence Significance sterilizing immunity target tested tissue Transport upstream utility Vaccine vaccine antigen vaccine immunogenicity vaccine platform Vaccines viral RNA load virus whole-genome [DOI] 10.1073/pnas.2025622118 PMC 바로가기 [Article Type] 423
Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2이전에 SARS-CoV-2에 감염된 의료 종사자의 단일 백신 접종 후 결합 및 중화 항체 역가Article Published on 2021-04-132022-09-12 Journal: JAMA [Category] MERS, SARS, 진단, [키워드] binding coronavirus vaccine dose Health care worker infected with SARS-CoV-2 mRNA neutralizing antibody SARS-CoV-2 titer worker [DOI] 10.1001/jama.2021.3341 PMC 바로가기 [Article Type] Article
A human coronavirus evolves antigenically to escape antibody immunity인간 코로나 바이러스는 항체 면역을 피하기 위해 항원 적으로 진화합니다.Research Article Published on 2021-04-082022-08-13 Journal: PLoS Pathogens [Category] Biology and Life Sciences, COVID-19, SARS, [키워드] 229E 229E strain 229E strains 229E viral strain 229E viruses accumulate anti-SARS-CoV-2 titer anti-SARS-CoV-2 titers antibody antibody immunity antigenic evolution common-cold comparable coronavirus coronavirus 229E coronavirus vaccine Coronavirus vaccines Coronaviruses degrade elicited Evolution Hope human coronavirus human coronavirus 229E human sera Hypothesis identify Immunity in some individuals Infection less Mutation neutralization neutralize Neutralizing titer neutralizing titers NTD occur Older other coronaviruses pace PROTECT question re-infect Re-infection Re-infections Receptor-binding domain Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccines seasonal coronavirus sera Spike protein strain Strains subsequent the RBD the receptor-binding domain titers vaccination variants of SARS-CoV-2 Viral viral evolution viral mutation Viral mutations viral spike viral strains virus viruses was collected [DOI] 10.1371/journal.ppat.1009453 PMC 바로가기 [Article Type] Research Article
Impact of COVID-19 on the social, economic, environmental and energy domains: Lessons learnt from a global pandemicReview article Published on 2021-04-012022-10-05 Journal: Sustainable Production and Consumption [Category] 신약개발, [키워드] affected Analysis benefit comprehensive analysis coronavirus vaccine COVID-19 COVID-19 outbreak Delay domain domains ecological Efficacy Environmental pollution expected global pandemic globe growth Health Impact information lesson NO2 emission pandemic PM emission preventive measure quarantine reduce response robust SARS-CoV-2 significantly Spread Transmission virus Waste generation [DOI] 10.1016/j.spc.2020.10.016 [Article Type] Review article
One or two injections of MVA-vectored vaccine shields hACE2 transgenic mice from SARS-CoV-2 upper and lower respiratory tract infectionMVA 벡터 백신을 1~2회 주사하면 SARS-CoV-2 상부 및 하부 호흡기 감염으로부터 hACE2 형질전환 마우스를 보호할 수 있습니다423 Published on 2021-03-232022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-RBD antibodies antibody Cancer Cell chemokine clinical study Combination coronavirus coronavirus vaccine COVID-19 cytokine Deletion detection Diseases eight Express expressing form full-length S furin hACE2 hACE2 receptor human clinical trials IFNγ immune response immune responses Immunity immunized immunogenic in vitro indicated infected cells Infection infection with SARS-CoV-2 Infectious disease Infectious diseases inhibited injection Intramuscular injection intranasal lethal infection Lower respiratory tract lung Lungs mice modifications modified vaccinia virus modified vaccinia virus Ankara morbidity mRNAs Mutation nasal turbinate nasal turbinates neutralized neutralizing antibody nucleic acids occurred other infectious diseases pandemic passive transfer peptide Prevent prevented proline proline substitutions Protein Proteins provided pseudovirus purified RBD question RBD Receptor binding domain recombinant reduced Replication required respiratory S protein Safe SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 S protein severe acute respiratory syndrome Coronavirus severe disease shown signal peptide Significance single vaccination smallpox vaccine Spread stimulate subgenomic mRNA subgenomic mRNAs subgenomic viral mRNA subgenomic viral mRNAs T cells the S protein the SARS-CoV-2 the signal peptide transfer transgenic mice Transgenic mouse transgenic mouse model transmembrane domain transmembrane domains upper and lower respiratory tracts vaccination Vaccine vaccinia virus Ankara vector vectors Viral virus Virus vector weight loss [DOI] 10.1073/pnas.2026785118 PMC 바로가기 [Article Type] 423
Immunoinformatics and Molecular Docking Studies Predicted Potential Multiepitope-Based Peptide Vaccine and Novel Compounds against Novel SARS-CoV-2 through Virtual ScreeningResearch Article Published on 2021-02-262022-10-27 Journal: BioMed Research International [Category] [키워드] Analysis analyzed antigenic epitope antigenic site approach attack authority B-cell epitope binding affinity binding domain binding energy binding interaction Compound conserved coronavirus coronavirus protein coronavirus vaccine CoVs CTL epitope cytotoxic death disease docked complex docking complex drug drug target epitope exhibited exhibiting food Genome HLA Human immunoinformatics inhibit investigated linker mammal MERS-CoV MHC-I molecular docking multiepitope vaccine Multiple new strain novel pathogenic virus peptide peptide vaccine peptide-based vaccine Potential predict predicted Protein Replication reported Result RNA virus SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus Screening selected sequence specific treatment spike target the SARS-CoV-2 virus unique variety was performed was used [DOI] 10.1155/2021/1596834 PMC 바로가기 [Article Type] Research Article
Immunoinformatics and Molecular Docking Studies Predicted Potential Multiepitope-Based Peptide Vaccine and Novel Compounds against Novel SARS-CoV-2 through Virtual ScreeningResearch Article Published on 2021-02-262022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, [키워드] Analysis analyzed antigenic epitope antigenic site approach attack authority B-cell epitope binding affinity binding domain binding energy binding interaction Compound conserved coronavirus coronavirus protein coronavirus vaccine CoVs CTL epitope cytotoxic death disease docked complex docking complex drug drug target epitope exhibited exhibiting food Genome HLA Human immunoinformatics inhibit investigated linker mammal MERS-CoV MHC-I molecular docking multiepitope vaccine Multiple new strain novel pathogenic virus peptide peptide vaccine peptide-based vaccine Potential predict predicted Protein Replication reported Result RNA virus SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus Screening selected sequence specific treatment spike target the SARS-CoV-2 virus unique variety was performed was used [DOI] 10.1155/2021/1596834 PMC 바로가기 [Article Type] Research Article