Limited induction of SARS-CoV-2–specific T cell responses in children with multisystem inflammatory syndrome compared with COVID-19COVID-19에 비해 다기관 염증 증후군 아동에서 SARS-CoV-2-특이 T 세포 반응의 제한된 유도Research Article Published on 2022-02-222022-09-10 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 치료법, [키워드] Adaptive immunity B cell responses CD4 CD8 Cellular immune response children contribute convalescent COVID-19 cytokine cytokine production cytokine response demonstrated develop full-length functional healthy controls Inflammatory Limited MIS-C mononuclear cell mononuclear cells nucleocapsid participant Pathogenesis peptides Peripheral blood Peripheral blood mononuclear cells plasma predominant quantified RBD Receptor binding domain responses against SARS-CoV-2 antigen SARS-COV-2 infection serologic Serologic response serologic responses significantly lower Spike receptor binding domain subset Support syndrome T cell T cell response T cell responses T cells Th1 Viral Viral proteins was reduced with COVID-19 [DOI] 10.1172/jci.insight.155145 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 variants of concern display enhanced intrinsic pathogenic properties and expanded organ tropism in mouse models우려되는 SARS-CoV-2 변이체는 마우스 모델에서 향상된 고유 병원성 특성 및 확장된 기관 친화성을 나타냅니다.Article Published on 2022-02-152022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] accelerated ACE2 receptor Alpha Alpha variant Antibody neutralization Beta Beta variant cellular cellular immunity curtail cytokine cytokine production Depletion disease Disease progression elicit expand Gamma Gamma variant gastrointestinal tract hACE2 host range human ACE2 immune activation immune responses induce Infection Inflammation innate immune response interferon intrinsic ISG ISG expression K18-hACE2 lung Lungs management mice mouse model murine Natural killer cells neutralization organ pandemic pathogenic pathogenicity reduced replicate responses reveal SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spread Symptoms systemic infection tissue transgenic Transmissibility Trigger variants variants of concern VoC VOCs wild-type zoonotic transmission [DOI] 10.1016/j.celrep.2022.110387 PMC 바로가기 [Article Type] Article
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challengeBCG의 정맥 투여는 치명적인 SARS-CoV-2 공격으로부터 마우스를 보호합니다Brief Definitive Report Published on 2022-02-072022-09-10 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] addition Administered alteration Analysis bacille Calmette-Guérin BCG BCG vaccination Cell cellular compartment clinically COVID-19 cytokine cytokine production Host immunopathology increase in Inflammatory inflammatory cell innate response intravenous Intravenous administration long-lasting mechanism mice Multivariate analysis myeloid cell nonspecific Pathogens pediatric phenomenon promote PROTECT provide pulmonary immune response recruitment reduced viral load reduced viral loads reducing reductions reductions in reported SARS-CoV-2 SARS-COV-2 infection subcutaneous route tissue pathology transgenic mice Tuberculosis vaccination variant Viral Viral load virus while [DOI] 10.1084/jem.20211862 PMC 바로가기 [Article Type] Brief Definitive Report
Heterologous Immunity Between SARS-CoV-2 and Pathogenic BacteriaImmunology Published on 2022-01-272022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] Activation acute respiratory syndrome Asymptomatic Bacterial bacterial pathogen bystander CD69 Cell co-culture coronavirus coronavirus disease COVID-19 cross-reactive cross-reactivity cytokine production Donor Effect elicited explain extension Heterologous heterologous immunity high variability IFN-γ IL-2 Immunity in silico in vitro individual induce mechanism memory T memory T cell non-structural protein offered outcome outcomes pathogen pathogenic bacteria peptide peptides proliferation recall recognize response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 vaccination SARS-CoV-2 vaccine sequence homology severity Spike protein T cell T cell response tested the SARS-CoV-2 the spike protein TNF vaccination [DOI] 10.3389/fimmu.2022.821595 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response Research Published on 2022-01-252022-10-05 Journal: Nature Aging [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] administration bronchial organoids caused CDKN2A Cell cellular senescence COVID-19 cytokine production described detectable Express expression human cell Infection Inflammation Inflammatory factor Inflammatory response involved lung marker mechanism mice mouse-adapted strain paracrine Patient persist phenotype reduced report SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell SASP senescent cell sustained syndrome Trigger undetectable uninfected cell virus [DOI] 10.1038/s43587-022-00170-7 [Article Type] Research
Innate Immune Responses of Vaccinees Determine Early Neutralizing Antibody Production After ChAdOx1nCoV-19 VaccinationImmunology Published on 2022-01-252022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] Activation adaptive adenoviral vector vaccine adenovirus vector vaccine age antibody Antibody titer association AZD1222 B cell CD14 CD27 CD3 CD56 CD86 Cell ChAdOx1 nCoV-19 collected connection correlated CpG Critical cytokine production double-negative B cell enrolled Ex vivo expression first vaccination FIVE flow cytometry granzyme B IFN-γ IGD imiquimod Immune cell immune response Immunity immunosenescence information Innate innate immune innate immune activation innate immune response Innate immunity LPS marker memory B cell monocyte naïve naïve B cell natural killer neutralization Neutralizing antibodies neutralizing antibody NK cell Older pattern recognition receptor Production response responses Result SARS-CoV-2 vaccines SARS-CoV2 serum significantly higher stimulated subject sVNT TLR TLR agonist TLR stimulation TLR9 Toll-like receptor vaccination vaccinee Virus neutralization were measured [DOI] 10.3389/fimmu.2022.807454 PMC 바로가기 [Article Type] Immunology
Tissue-level alveolar epithelium model for recapitulating SARS-CoV-2 infection and cellular plasticitySARS-CoV-2 감염 및 세포 가소성을 요약하기 위한 조직 수준 폐포 상피 모델Article Published on 2022-01-192022-09-12 Journal: Communications Biology [Category] SARS, 진단, 치료제, [키워드] Activation alveolar alveolar cell alveolar epithelial cells alveolar epithelium Cell cells cellular clinically COVID-19 Culture cytokine production damaged exhibit feature IMPROVE Infection Injury mechanism media Pathogenesis plasticity Pneumonia Prevent primary cell pulmonary pulmonary fibrosis Research Respiratory system models SARS-COV-2 infection SARS-CoV-2 pseudovirus subsequent translational viral entry viral infection Wnt signaling [DOI] 10.1038/s42003-022-03026-3 PMC 바로가기 [Article Type] Article
SARS-CoV-2-Specific T Cell Responses Are Stronger in Children With Multisystem Inflammatory Syndrome Compared to Children With Uncomplicated SARS-CoV-2 InfectionSARS-CoV-2-특이적 T 세포 반응은 단순 SARS-CoV-2 감염 아동에 비해 다기관 염증 증후군 아동에서 더 강력합니다Comparative Study Published on 2022-01-182022-09-11 Journal: Frontiers in Immunology [Category] 진단, 치료법, [키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Adults antibody Antigen Blood children collected convalescent Coronavirus-2 COVID-19 CST cytokine cytokine production evaluated finding flow cytometry Immunity Infection LIPS luciferase Luciferase immunoprecipitation system magnitude manifestation MIS-C morbidity and mortality nucleocapsid Patient patients pediatric peptides Presence rates of infection respiratory response risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific peptides seropositive Seropositivity serum/plasma Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly higher specificity Stimulation surface markers T cell was measured [DOI] 10.3389/fimmu.2021.793197 PMC 바로가기 [Article Type] Comparative Study
Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naive and subjects recovered from COVID-19BNT162b2 mRNA 백신 접종 후 세포 및 체액 기능 반응은 순진한 피험자와 COVID-19에서 회복된 피험자 사이에 세로로 다릅니다Article Published on 2022-01-112022-09-12 Journal: Cell Reports [Category] SARS, 진단, [키워드] acute respiratory syndrome analyzed antigen-specific T cell B cell BNT162b2 BNT162b2 mRNA vaccination BNT162b2 vaccine both group both groups CD4 cell-mediated response cellular Cellular responses comparable coronavirus coronavirus disease COVID-19 COVID-19-recovered cytokine cytokine production determine functional humoral humoral responses Immunoglobulin individual inverse correlation memory B memory B cell neutralization capacity neutralizing antibody proliferation reduced response SARS-CoV-2 second dose spike subject subjects T cell activation vaccination Vaccine vaccine-induced immune response variable [DOI] 10.1016/j.celrep.2021.110235 PMC 바로가기 [Article Type] Article
Disorders of the Cholinergic System in COVID-19 Era—A Review of the Latest ResearchReview Published on 2022-01-082022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] ACE Acetylcholine acetylcholinesterase agonist angiotensin-converting enzyme 2 antiviral drug antiviral drugs binding can be used cause caused change cholinergic cholinergic system complex conducted connection COVID-19 COVID-19 virus cytokine production Cytokine storm demonstrated develop disorder disrupt dysregulation Effect epitope example in vitro in vivo inhibit initiated Morphological negative influence nervous system Nicotine nicotinic receptors Non-invasive physiological Prevent receptor reduce Research review SARS-CoV-2 SARS-CoV-2 spike protein sequence Structure System the SARS-CoV-2 virus therapy these compound virus [DOI] 10.3390/ijms23020672 PMC 바로가기 [Article Type] Review