An EUA for anakinra (Kineret) for COVID-19Article Published on 2022-12-122023-07-11 Journal: The Medical letter on drugs and therapeutics [Category] COVID19(2023년), [키워드] actemra adverse effects Anakinra Baricitinib Corticosteroids COVID-19 Dexamethasone dosage Drug interactions Efficacy lactation Olumiant Pregnancy Remdesivir Safety Tocilizumab Veklury
High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasoneArticle Published on 2022-11-052022-11-15 Journal: Respiratory Research [Category] SARS, 바이오마커, [키워드] Admission association Biomarker Biomarkers Blood level Clinical management Control correlated covariates COVID-19 COVID-19 patient COVID-19 patients death Determination Dexamethasone died disease severity elevated Follow-up greater host inflammatory response IL-6 increased risk independent Infection Inflammation investigated Mortality NEWS2 Patient patient population patients patients treated Pearson positive positive individual predict prognostic RAGE receptor reduce risk SARS-CoV-2 score second wave significantly lower sRAGE. subject Teaching treated Treatment university [DOI] 10.1186/s12931-022-02220-5 PMC 바로가기
Reactive synovitis of the knee joint after COVID-19 vaccination: The first ultrastructural analysis of synovial fluidArticle Published on 2022-11-012022-11-15 Journal: International journal of rheumatic diseases [Category] SARS, 치료기술, [키워드] acute respiratory syndrome Administered adverse event affected Analysis Arthritis blood test clinical examination complex Consequences coronavirus coronavirus 2019 disease COVID-19 COVID-19 vaccination COVID-19 vaccine cytological-energy analysis detect Dexamethasone Diseases dose examined excluded Fever first dose follow-up period full recovery Infection intravenously joint Messenger RNA outcome Patient polymerase chain reactive Reactive arthritis recorded resulting reverse transcription SARS-CoV-2 Side-effects Spread Symptom synovial fluid therapy Treatment Ultrastructural analysis Vaccine Vaccines virus with COVID-19 [DOI] 10.1111/1756-185X.14411 PMC 바로가기
Central Retinal Vein Occlusion After Discontinuation of Rivaroxaban Therapy in a Young Patient with COVID-19 Pulmonary Embolism: A Case ReportArticle Published on 2022-11-012022-11-15 Journal: The American journal of case reports [Category] 진단, [키워드] anticoagulation Combination common contributing to Convalescent plasma therapy Course COVID-19 decrease Dexamethasone diagnosed discharge edema Factor healthy Hospitalized hypercoagulability initiated intravitreal injection knowledge occurred Oxygen therapy Patient Prophylactic pulmonary rebound Remdesivir report retinal vein retinal vein occlusion rivaroxaban Severe COVID-19 pneumonia significantly subsegmental the patient therapeutic therapy treated Treatment visual acuity was performed were excluded with COVID-19 [DOI] 10.12659/AJCR.937739 PMC 바로가기
COVID-19 Molecular Pathophysiology: Acetylation of Repurposing DrugsReview Published on 2022-10-312023-07-10 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), [키워드] ACE2 (angiotensin-converting enzyme 2) Aspirin cGAS–STING (cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS)–stimulator of interferon genes (STING)) dapsone Dexamethasone immunologic engram Inflammasome SAMHD1 (sterile alpha motif and histidine-aspartate domain-containing protein 1) SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) Spike protein TLR4 (Toll-like receptor 4) [DOI] 10.3390/ijms232113260 PMC 바로가기 [Article Type] Review
Abrogation of neutrophil inflammatory pathways and potential reduction of neutrophil-related factors in COVID-19 by intravenous immunoglobulinArticle Published on 2022-10-202022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] abrogation Activation acute respiratory distress addition Alter ARDS cell-free DNA circulation Clinical treatment Corticosteroids Course COVID-19 COVID-19 patient Critically ill Dexamethasone dose-dependent elevated Ex vivo Factor functions healthy controls healthy donor healthy donors IL-8 inflammatory pathway Intravenous immunoglobulin Intravenous immunoglobulin (IVIG) lack Level Lung injury lung parenchyma modulate NET NETosis NETs neutrophil Neutrophil elastase Neutrophil extracellular trap neutrophil function Neutrophils not affect oxidative oxidative burst Patient Peripheral blood phagocytosis PMA pro-inflammatory function Proteins reactive oxygen specy reduced reduction severity syndrome targeting therapeutic therapeutic agent Tocilizumab treated Treatment were assessed while with COVID-19 [DOI] 10.3389/fimmu.2022.993720 PMC 바로가기
Multi-Omics Reveals Mechanisms of Partial Modulation of COVID-19 Dysregulation by Glucocorticoid TreatmentArticle Published on 2022-10-112022-11-16 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] acquisition Amino acid analysed Analysis arginine caused Cohort Concentration COVID-19 COVID-19 infection COVID-19 infections COVID-19 pathogenesis dataset degranulation Dexamethasone dysregulation effective feature glucocorticoid Glucocorticoid treatment Glucocorticoids Guidance highlight include indicated Interaction mass spectrometry metabolomics modulation mortality rates Multi-omics neutrophil oxygen supplementation pandemic Partial participant pathway Pathway analysis Patient Platelet proteomics Quantitative serum statistically significant Treatment treatment regimen tyrosine was performed [DOI] 10.3390/ijms232012079 PMC 바로가기
Old drugs, new tricks: leveraging known compounds to disrupt coronavirus-induced cytokine stormArticle Published on 2022-10-102022-11-16 Journal: NPJ Systems Biology and Applications [Category] COVID19(2023년), SARS, 신약개발, [키워드] acute respiratory distress agonists Antimicrobials approach approved drugs automated biological pathway candidate drug Combination competing complex Compound compounds COVID-19 infection Cytokine storm Dexamethasone disrupt downstream interaction driving drug drug combination Drug discovery drugs drugs targeting dysregulation Effects element engage functional Host host immune system identify immune in silico Approach Interaction Intervention less mTOR inhibitor other disease peer-reviewed predicted Regulatory scored signaling cascade significantly subset suppressor syndrome target while [DOI] 10.1038/s41540-022-00250-9 PMC 바로가기
Real-world effectiveness of steroids in severe COVID-19: a retrospective cohort studyArticle Published on 2022-10-052022-11-16 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] age analysed association clinical co-morbidity Cohort confounder Controlled trial Coronavirus disease 2019 COVID-19 defined Dexamethasone disease Effectiveness EPR Gender hazard hospital Hydrocortisone hypoxia in-hospital mortality individual Methylprednisolone Mortality multivariable multivariate model outcome Patient positive patient Prednisolone protective effect randomised clinical trial reduce replicate replicated reported retrospective cohort study Retrospective study risk SARS-CoV-2 RNA SARS-CoV-2 variant severe COVID-19 shown steroid steroid treatment Steroids treated Treatment viral genome was measured [DOI] 10.1186/s12879-022-07750-3 PMC 바로가기
Factors Associated With Severe COVID-19 Among Vaccinated Adults Treated in US Veterans Affairs HospitalsArticle Published on 2022-10-032022-11-15 Journal: JAMA Network Open [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% CI adjusted odds ratio Affair age antiviral therapy association benefit black blood oxygen level booster booster vaccination Breakthrough infection Characteristics Chemotherapy chronic condition Chronic kidney disease collected Comorbidities conditions COVID-19 death defined Dementia demographic Department development Dexamethasone diagnostic disease dose effort end-organ Factor finding heart failure Hispanic Hospitalization hospitals identify immunocompromised status Immunosuppressive medication increase in increased risk Infection laboratory-confirmed SARS-CoV-2 infection less leukemia leukocyte logistic regression models lymphoma male mechanical ventilation men Older outcome Patient positive preexposure prophylaxis proportion receipt reduced retrospective cohort retrospective cohort study risk risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination severe COVID-19 severe COVID-19 disease severe disease Severe infection supplemental oxygen treated vaccination Vaccine variables veteran veterans white [DOI] 10.1001/jamanetworkopen.2022.40037 PMC 바로가기