Rampant C→U Hypermutation in the Genomes of SARS-CoV-2 and Other Coronaviruses: Causes and Consequences for Their Short- and Long-Term Evolutionary TrajectoriesResearch Article Published on 2020-06-242022-10-30 Journal: mSphere [Category] COVID-19, SARS, [키워드] acute respiratory syndrome adaptive Amino acid amino acid change Analysis antiretroviral Antiviral APOBEC cause change comparable Complete consequence coronavirus coronavirus COVID-19 curated Defense directional driven by Effect event Evidence Evolution Frequency G+C content Genome HCoV-NL63 Host host cell hosts human coronavirus hypermutation implication initial Intensive mechanism Middle East Molecular epidemiology motif Mutation Neutral normalized nucleotide occurred Occurrence Other other coronavirus pandemic proportion Proteins provide SARS SARS coronavirus 2 SARS-CoV SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 variant sequence Spread substitutions syndrome virus widespread [DOI] 10.1128/mSphere.00408-20 PMC 바로가기 [Article Type] Research Article
SARS‐CoV‐2, an evolutionary perspective of interaction with human ACE2 reveals undiscovered amino acids necessary for complex stabilityOriginal Article Published on 2020-05-072022-10-31 Journal: Evolutionary Applications [Category] COVID-19, [키워드] ACE2 Amino acid Analysis betacoronavirus betacoronavirus spike protein binding cell receptor complex conserved coronavirus coronavirus Critical death determine directional effective ENhance evolutionary dynamics Factor FIVE genomic region glycine hACE2 host cells human ACE2 human cell human cells human host implicated IMPROVE infect Infection infections inhibiting binding Interaction modeling molecular dynamics performed Perspective Positive selection predict purifying selection receptor receptor ACE2 receptor‐binding domain residue reveal Salt Bridge SARS‐CoV‐2 SARS‐CoV‐2 selection pressure spike glycoprotein Spike protein stability viral evolution viral lineages viral spike protein virus [DOI] 10.1111/eva.12980 PMC 바로가기 [Article Type] Original Article
Directional and reoccurring sequence change in zoonotic RNA virus genomes visualized by time-series word countArticle Published on 2016-11-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] activity addition analysis change changes in condition diagnostic directional Ebola Ebolavirus Effectiveness Epidemics Factors Genome growth Host hosts human cell influenza A influenza A virus Influenza virus Invasion Long MERS coronavirus Middle East mutate oligonucleotide outbreak primer RNA virus RNA viruses RT-PCR sequence siRNAs subtype Subtypes therapeutic thought virus West zoonotic [DOI] 10.1038/srep36197 PMC 바로가기 [Article Type] Article
Extreme Population Differences in the Human Zinc Transporter ZIP4 (SLC39A4) Are Explained by Positive Selection in Sub-Saharan Africa인간 아연 수송체 ZIP4(SLC39A4)의 극단적인 인구 차이는 사하라 사막 이남의 아프리카에서 양성 선택으로 설명됩니다Research Article Published on 2014-02-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accompanied acrodermatitis acrodermatitis enteropathica African allele allele frequencies allele frequency Amino acid Author biological function Cell characterized classical computer simulations Concentration deficiency derived allele difference different directional disease phenotype disease risk DNA Evidence explained expression extreme finding fixation found functional Genetic Health HeLa cells homeostasis hotspot Human human population human populations implication intestinal investigated isoform leucine Local locus membrane Mutation natural selection Neanderthal Non-synonymous overexpression pathogen Pathogens polymorphism Population positive Positive selection Protein Recombination reduced reducing regulated Regulation Research Selection selective sweep significantly SLC39A4 sub-Saharan Africa surface protein Trace element transporter valine variant West Zinc zinc deficiency [DOI] 10.1371/journal.pgen.1004128 PMC 바로가기 [Article Type] Research Article
Chromosomal Copy Number Variation, Selection and Uneven Rates of Recombination Reveal Cryptic Genome Diversity Linked to Pathogenicity염색체 복사 수 변이, 선택 및 재조합의 불균등한 비율은 병원성과 관련된 비밀 게놈 다양성을 나타냅니다Research Article Published on 2013-08-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive addition analysis asexual association Author Batrachochytrium dendrobatidis change changes in characterized chromosomal chromosome contribute contributed copy copy number Culture de novo directional Diversity ecological niche ecological niches effort Evidence evidence of Evolution explain Factors feature fungal fungi Gene Genetic Genome genomes growth Host hot spots in vitro infect isolate knowledge Lineage lineages majority manifested mechanism microbial number occur organism pathogen pathogenicity Pathogens phenotypic ploidy Rate Recombination Region replicate reported reproduction response Secretome Selection sequenced target Transmission Variability Variation virulence virulence factors widespread [DOI] 10.1371/journal.pgen.1003703 PMC 바로가기 [Article Type] Research Article
A Protective Role for ELR+ Chemokines during Acute Viral EncephalomyelitisResearch Article Published on 2009-11-062022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] abrogated absence acute viral infection Alter antibody Author blocking Blood Brain Central nervous system characterized chemokine Chemokine receptor chemotaxis clinical outcomes CNS compensatory mechanism consequence contribute CXCL1 CXCL2 CXCL5 CXCR2 Defense defined directional Encephalitis Encephalomyelitis Evidence expressed expressing expression facilitate functional highlight Host impair in vitro increased expression indicated Infection infiltration Inflammatory Injury inoculation involved leukocytes Ligand lymphocyte mice microbial infection Migration modulate Mortality mouse hepatitis virus myeloid cells neurotropic neutralization neutrophil Neutrophils pathogen poliomyelitis proinflammatory receptor recruitment reduced reduction required role shown Signaling survived T cell responses T cells transcript viral clearance viral infection viral replication viral-induced virus was determined [DOI] 10.1371/journal.ppat.1000648 PMC 바로가기 [Article Type] Research Article