downregulated – Page 4 – Communicable Diseases Research

In Silico Infection Analysis (iSFA) Identified Coronavirus Infection and Potential Transmission Risk in Mammals

Molecular Biosciences

Published on 2022-02-082022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

MERS-CoV nsp1 impairs the cellular metabolic processes by selectively downregulating mRNAs in a novel granules

Research Article

Published on 2022-02-062022-10-28
Journal: Virulence [Category] COVID-19,

Possible kidney-lung cross-talk in COVID-19: in silico modeling of SARS-CoV-2 infection

COVID-19에서 가능한 신장 폐 크로스 토크 : SARS-COV-2 감염의 실리코 모델링에서

Research Article

Published on 2022-02-052022-09-10
Journal: BMC Nephrology [Category] COVID19(2023년), Fulltext, MERS, SARS, 유전자 메커니즘,

[키워드] ACE2 Acute kidney injury affected AKI angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach Candidates caused cell entry change changes in COVID receptors COVID-19 COVID-19 infection cross-talk dataset downregulated Effects enzyme evaluated experimental model experimental models expression fold Gene Expression Genes Genomics hypothese in silico in silico analysis in silico Approach Inhbb Injury Invasion involved kidney Kidney-lung cross-talk kidneys Lcn2 leads lung Lung injury Lungs Maff mechanical ventilation mechanism Microarray molecular mouse model Mouse models organs Pneumonia progression protease question Result reveal SARS-CoV-2 SARS-COV-2 infection Serine serine 2 SOCS3 target targets TMPRSS2 transmembrane transmembrane protease serine 2 upregulated while
[DOI] 10.1186/s12882-022-02682-1 PMC 바로가기 [Article Type] Research Article

B Cell Composition Is Altered After Kidney Transplantation and Transitional B Cells Correlate With SARS-CoV-2 Vaccination Response

Medicine

Published on 2022-02-022022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] 105 patient affected Altered Analysis antibody Antigen B cell B cells Blood BNT162b2 CD27 CD5 CD86 change CKD CKD G5 collected COVID-19 COVID-19 pandemic dialysis dose double negative downregulated Efficacy explain expression flow cytometric Follow-up Frequency heterogeneous immune response implication increased mortality individuals investigated kidney kidney transplant recipient Kidney transplantation lymphocyte memory mRNA-1273 mRNA-based vaccine naïve non-responders Patient patients Peripheral blood plasmablast recruited reduced remained response Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination seroconversion rate serological response shown significantly subjects subpopulation subset transplantation vaccination Vaccination strategies venous was performed
[DOI] 10.3389/fmed.2022.818882 PMC 바로가기 [Article Type] Medicine

All-Trans Retinoic Acid Attenuates Transmissible Gastroenteritis Virus-Induced Inflammation in IPEC-J2 Cells via Suppressing the RLRs/NF‐κB Signaling Pathway

Immunology

Published on 2022-01-312022-11-01
Journal: Frontiers in Immunology [Category] Coronavirus,

[키워드] acid Activation all-trans retinoic acid anti-inflammatory activity ATRA attenuate Cell cells damaged downregulated downstream economic loss epithelial epithelial cell gastroenteritis IL-1β IL-6 IL-8 immunomodulatory properties indicated Infection Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines Inflammatory response inhibiting inhibitor Injury intestinal intestinal inflammation IPEC-J2 cells damage knockdown MAVS MDA5 mechanism molecular mechanism mRNA abundance mRNA expression NF-κB nuclear translocation occludin p65 Pathogenesis Phosphorylation prevented pro-inflammatory cytokines protective effect protein level reduced reduction resulting reversed RIG-I RLRs/NF‐κB pathway signaling molecule signaling pathway significantly Suppressing TGEV TLR3 TLR7 TNF-α Traf6 transmissible gastroenteritis virus Treatment TRIF triggered upregulation ZO-1
[DOI] 10.3389/fimmu.2022.734171 PMC 바로가기 [Article Type] Immunology

Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart

심장 SARS-CoV-2 감염은 심장 내 전염증성 전사체 변화와 관련이 있습니다

Article

Published on 2022-01-292022-09-11
Journal: Cardiovascular Research [Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료제,

[키워드] adverse outcome Analysis Atla Autopsy cardiac Cardiac infection Cardiac signature matrix caused cDNA Cell consequence COVID-19 Cytometry Deceased DEGs destruction Diagnosis differentially expressed gene downregulated Effects endothelial Endothelial cell endothelial cells fraction Gene ontology GO term heart heart tissue ICAM1 identify IFI44L Immune cell Immune cell infiltration immune response Immunofluorescent staining immunohistochemistry In situ hybridization Increased Infection interferon interferon pathway investigated MACE marker massive molecular MYPN no difference NPPB paracrine Pathomechanism positive pro-inflammatory pro-inflammatory gene expression q-value Quantitative reveal RNA-Seq RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus sequencing data signature matrix single-cell dataset staining tissue transcriptomic alteration TRIM25 upregulated Viral Viral protein virus virus load was performed while
[DOI] 10.1093/cvr/cvab322 PMC 바로가기 [Article Type] Article

Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients

통합된 조직병리학, 지질학 및 대사체 프로필은 밍크가 심각한 COVID-19 환자의 병원성을 모방하는 유용한 동물 모델임을 보여줍니다

Article

Published on 2022-01-282022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 진단, 치료법, 치료제,

[키워드] Absorption accompanied activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus alteration alveolar damage amino acids Analysis animal model Anti-inflammatory characterized cholesterol contributed coronavirus correlated COVID-19 patients demonstrated Diffuse alveolar damage digestion digestive distribution downregulated dysregulation effective Effects Endocrine fatal COVID-19 feature fetal hepatic dysfunction highlight histological histopathological Human immune dysregulation immune systems immunomodulating Infection Infectious diseases Inflammatory response inoculation Kynurenine Kynurenine pathway lesion Lipid lipids Macrophage macrophage activation macrophages melatonin metabolic pathways metabolite metabolites metabolomic observation pathogenicity pathophysiological feature Patient post inoculation potential biomarkers profile Proteins reported Research respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient significantly Steroids transmitted Treatment strategies Vaccine Viral Viral protein vitamins was related widespread
[DOI] 10.1038/s41392-022-00891-6 PMC 바로가기 [Article Type] Article

Elimination of Aicardi–Goutières syndrome protein SAMHD1 activates cellular innate immunity and suppresses SARS-CoV-2 replication

Aicardi-Goutières 증후군 단백질 SAMHD1 제거는 세포 선천 면역을 활성화하고 SARS-CoV-2 복제를 억제합니다

Research Article

Published on 2022-01-252022-09-10
Journal: The Journal of Biological Chemistry [Category] MERS, SARS, 치료제,

[키워드] 293T ACE2, angiotensin-converting enzyme 2 activate activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect AGS, Aicardi–Goutières syndrome Antiviral ARHGEF5, Rho guanine nucleotide exchange factor 5 Baricitinib cDNA, complementary DNA Cell cell lines cells cellular characterized clearance coronavirus COVID-19, Coronavirus disease 2019 CRISPR Culture Degradation demonstrated DMEM, Dulbecco's modified Eagle's medium downregulated elevated Elimination expression FBS, fetal bovine serum FDA, US Food and Drug Administration Gene Expression Genetic HCoV-OC43, human coronavirus OC43 human coronavirus human coronavirus OC43 IFN IFN signaling IFN, interferon IFNs immune responses Infection innate immune response Innate immunity interferon interferons interferons (IFNs) IRF3, IFN regulatory factor 3 ISG, IFN-stimulated gene JAK inhibitor JAK pathway JAK, Janus kinase lack lentiviral Macrophage macrophages MDM, monocyte-derived macrophage model system MOI, multiplicity of infection Monocyte-derived macrophages mRNA NSP, nonstructural protein Pathways Phosphorylation Protein protein expression pSTAT1, phosphorylated form of STAT1 qRT–PCR, quantitative RT–PCR regulate Replication respiratory SAMHD1 SAMHD1, sterile alpha motif and histidine–aspartate domain–containing protein 1 SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA SARS-CoV-2–infected patient SARS-CoV-2–infected patients SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome Coronavirus shown Signaling signaling pathway significantly increased Stat1 STAT1, signal transducer and activator of transcription 1 suppresse suppressed syndrome THP-1 tissue tissue culture Treatment upregulated Viral Viral protein Virus-like particle virus-like particles VLP, virus-like particle Vpx, viral protein X
[DOI] 10.1016/j.jbc.2022.101635 PMC 바로가기 [Article Type] Research Article

Meta-Analysis of APP Expression Modulated by SARS-CoV-2 Infection via the ACE2 Receptor

Article

Published on 2022-01-212022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

[키워드] ACE2 acute respiratory syndrome affected Alzheimer’s disease Alzheimer’s disease amyloid-beta precursor protein angiotensin-converting enzyme-2 app binding canonical caused characterized cleavage conducted core coronavirus Coronavirus-2019 COVID-19 downregulated exacerbating expression Infection Inflammation Ingenuity Pathway Analysis investigated involved IPA less Meta-analysis modulation Neuroinflammation P -value pathway plaque precursor progression Protein receptor resulting SARS-CoV-2 severe acute respiratory syndrome-coronavirus-2 signaling pathway upregulated upregulation upstream virus Z-score
[DOI] 10.3390/ijms23031182 PMC 바로가기 [Article Type] Article

Identification of hub genes associated with COVID-19 and idiopathic pulmonary fibrosis by integrated bioinformatics analysis

Research Article

Published on 2022-01-192022-10-28
Journal: PLoS ONE [Category] COVID-19,