enrolment – Page 4 – Communicable Diseases Research

Convalescent plasma in the treatment of moderate to severe COVID-19 pneumonia: a randomized controlled trial (PROTECT-Patient Trial)

중등도 내지 중증의 코비드 -19 폐렴의 치료에서의 회복기 혈장 : 무작위 대조 시험 (보호 환자 시험)

Clinical Trial

Published on 2022-02-152022-09-01
Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료법, 치료제,

Convalescent plasma for COVID-19 in hospitalised patients: an open-label, randomised clinical trial

Randomized Controlled Trial

Published on 2022-02-102022-10-04
Journal: The European Respiratory Journal [Category] COVID19(2023년), SARS, 임상,

[키워드] 1:1 28-day mortality 95% CI age Antibody titre assigned baseline Clinical improvement clinical trial convalescent plasma coronavirus disease COVID-19 Critically ill days alive Effect enrolment group groups hospitalised hospitalised patient interquartile range invasive investigator-initiated IQR Laboratory male marker median no significant difference Open-label Parallel Arm Patient patients plasma Primary outcome proportion randomisation randomised Randomly Respiratory Support Secondary outcomes Standard of care subgroups symptom onset the median therapy Trial ventilatory support with COVID-19
[DOI] 10.1183/13993003.01471-2021 PMC 바로가기 [Article Type] Randomized Controlled Trial

Impact of accreditation on health care services performance in Kiryandongo district, Uganda: a longitudinal study

Research

Published on 2022-02-102022-10-28
Journal: BMC health services research [Category] Coronavirus, COVID19(2023년), Fulltext, MERS, SARS,

Clinical research on COVID-19: perceptions and barriers to participation in The Gambia

COVID-19에 대한 임상 연구: The Gambia 참여에 대한 인식과 장벽

Article

Published on 2022-02-012022-09-11
Journal: BMJ Global Health [Category] COVID19(2023년), SARS, 임상,

[키워드] acceptability activity administration African Analysis clinical clinical trial clinical trials collected Community conducted COVID-19 COVID-19 testing detrimental effect detrimental effects Developing disease engage enrolled enrolment facilitator facilitators fear foster Government group discussion Health Health Education health education and promotion health system health systems evaluation household contacts identify implementation individual Local local government men MRC n=36 participated patients with COVID-19 Potential treatment Preserving prevention strategies privacy profiles promotion public health recorded Research Safe semistructured interview sick thematic analysis therapy Treatment Trial Trust unit was used West women
[DOI] 10.1136/bmjgh-2021-007533 PMC 바로가기 [Article Type] Article

Development and evaluation of rapid data-enabled access to routine clinical information to enhance early recruitment to the national clinical platform trial of COVID-19 community treatments

Methodology

Published on 2022-01-202022-10-29
Journal: Trials [Category] COVID-19, SARS,

[키워드] acute illness approach average Care clinical information clinical trials Community complications contributing to COVID-19 COVID-19 pandemic data data-driven Department development ENhance enrolment EudraCT Evidence healthcare high risk information Innovation IRAS ISRCTN methodology National NHS Older participant Participants Patient platform Platform trial Positive test positive test result primary care provided Public and patient involvement and engagement raised randomisation REC receiving Record recruit recruitment reduced Registered repurposed therapy required Research Result Safe SCR Standard supplementary material Test therapeutic trace Treatment Trial trial participant unique was used
[DOI] 10.1186/s13063-021-05965-4 PMC 바로가기 [Article Type] Methodology

Involving older people in co-designing an intervention to reverse frailty and build resilience

Randomized Controlled Trial

Published on 2022-01-192022-10-05
Journal: Family practice [Category] SARS, 임상,

[키워드] age approach build contributed dietary enrolment evaluated Exercise intervention feasibility feedback female females Follow-up frailty Gender group discussion Guidance Health IMPROVE Intervention Involvement Involving nine Older older people pandemic Patient PPI primary-care Public public and patient involvement randomised RCT Research Resilience resistance exercise stages supported systematic review technology Trial
[DOI] 10.1093/fampra/cmab084 PMC 바로가기 [Article Type] Randomized Controlled Trial

A phase 2 single center open label randomised control trial for convalescent plasma therapy in patients with severe COVID-19

중증 COVID-19 환자의 회복기 혈장 치료를 위한 2상 단일 센터 공개 라벨 무작위 대조 시험

Clinical Trial

Published on 2022-01-192022-09-12
Journal: Nature Communications [Category] SARS, 임상, 진단, 치료기술, 치료법,

[키워드] 95% confidence interval adverse effect Adverse reaction all-cause mortality ARDS benefit characterized clinical clinical benefit clinical trial clinical trials Controlled trial convalescent plasma Convalescent plasma therapy COVID-19 disease cytokine Cytokines enrolment Evidence FiO2 General Hospital hazard hyper-inflammation immunization immunological inclusion criteria India Infectious disease Infectious diseases Intervention Kolkata log-rank log-rank test Mantel-Haenszel mechanical ventilation Mild Mild ARDS moderate moderate ARDS Mortality neutralizing antibody not affect not significantly different on mechanical ventilation open label outcome Outcomes research p value PaO2 paO2/fiO2 passive immunization Patient patients patients hospitalized PCR Phase 2 plasma plasma therapy prespecified outcomes Primary outcome Primary outcomes proteome randomised randomised controlled trial Randomized Ratio recruited Registered registry reported response to therapy secondary outcome Secondary outcomes severe COVID-19 severe COVID-19 disease severe COVID-19 patient severe COVID-19 patients single center Standard of care systemic hyper-inflammation the systemic hyper-inflammation therapy treat Treatment treatment arm Trial viral infection Viral RNA was done
[DOI] 10.1038/s41467-022-28064-7 PMC 바로가기 [Article Type] Clinical Trial

Telehealth voice assessment by speech language pathologists during a global pandemic using principles of a primary contact model: an observational cohort study protocol

Observational Study

Published on 2022-01-172022-10-05
Journal: BMJ Open [Category] SARS, 임상,

[키워드] acute respiratory syndrome adult otolaryngology Analysis article association coast collected Complete Concordance Contact contagious country Diagnosis diagnostic disorder disorders enrolment Ethical approval Ethics ethics committee global pandemic gold Health Health Service healthcare worker Human include information initial International laryngeal laryngology maintain malignancy measure National nose and throat Observational cohort study offered outcome participant pathologist pathology Pathways Patient peer-reviewed Personal protective equipment physical distancing measure prospective observational cohort protocol provided reduce reference number Result SARS-CoV-2 service shown Sociodemographic speech pathology. spread to study outcome Symptom Symptoms telehealth Treatment usual care Variability
[DOI] 10.1136/bmjopen-2021-052518 PMC 바로가기 [Article Type] Observational Study

Safety and immunogenicity of a self-amplifying RNA vaccine against COVID-19: COVAC1, a phase I, dose-ranging trial

Research article

Published on 2022-01-142022-10-05
Journal: EClinicalMedicine [Category] 임상,

[키워드] 95% CI adverse event adverse events AEs AEsAdverse events anti-S IgG anti-SARS-CoV-2 antibody binding Citadel clinical development Clinical research collected Concentration conducted COVID-19 COVID-19 vaccine dose Dose escalation earth effective ELISA enrolled enrolment EudraCT facility finding Follow-up force funding gene of Interest geometric mean GOIgene of Interest healthy individual Humoral response IgG ELISA immunoblot immunogenic induce injection interval intramuscular Joseph Lipid Lipid nanoparticle LNP LNPlipid nanoparticle London low dose low dose vaccine Medical Research Council neutralisation neutralisation assays non-structural protein NSPnon-structural protein Open-label participant partner Phase I post-hoc raised ranged required RNA RNA vaccine Safe Safety saRNAself-amplifying RNA SARS-CoV-2 self-amplifying RNA sera Serious Adverse Event Seroconversion serological evidence Trial Trust vaccination Vaccine VEEVVenezuelan equine encephalitis virus Venezuelan equine encephalitis virus was measured was related wild type
[DOI] 10.1016/j.eclinm.2021.101262 [Article Type] Research article

Awake prone positioning in nonintubated spontaneous breathing ICU patients with acute hypoxemic respiratory failure (PRONELIFE)—protocol for a randomized clinical trial

삽관되지 않은 자발 호흡 중환자 중 급성 저산소성 호흡 부전(PROONELIFE) 환자의 깨어 있는 엎드린 자세 - 무작위 임상 시험을 위한 프로토콜

Study Protocol

Published on 2022-01-102022-09-10
Journal: Trials [Category] 임상,

[키워드] Acute hypoxemic respiratory failure Acute respiratory failure all-cause mortality assigned Awake prone positioning benefit Blinding Clinical management clinical trial complications Composite consecutive patients Critically ill Critically ill patient critically ill patients determine duration of use Dyspnea Effect eligible Endpoint enrolment etiology hospital Hypoxemia hypoxemic Hypoxemic respiratory failure ICU ICU patient ICU Patients include International intubation intubation rate invasive invasive ventilation investigator-initiated ISRCTN lung tissue Mortality multicenter noninvasive respiratory Other Oxygenation parameters Patient Pragmatic Prevent primary endpoint Prone position prone positioning randomized clinical trial Randomized controlled trial Randomly reduction in reference number Registered respiratory Respiratory failure secondary Secondary endpoints spontaneous breathing standard care Support Tolerance tracheal tracheal intubation Trial Ventilation
[DOI] 10.1186/s13063-021-05991-2 PMC 바로가기 [Article Type] Study Protocol