Quantification of airborne SARS-CoV-2 genomic particles in different hospital settings다른 병원 환경에서 공중 SARS-COV-2 게놈 입자의 정량화Article Published on 2021-10-282022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] Autopsy Brazil collected Concentration Contamination COVID-19 determine Diseases E-gene envelope protein Environmental sciences Genes genomic hospital ICU ICUs no significant difference nucleocapsid protein Particle PCR positive quantified Real-time reverse-transcription PCR SARS-CoV-2 SARS-CoV-2 RNA significant difference significantly higher ward was used widespread [DOI] 10.1038/s41598-021-00761-1 PMC 바로가기 [Article Type] Article
Potential Antigenic Cross-reactivity Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Dengue Viruses중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)와 뎅기열 바이러스 간의 잠재적 항원 교차 반응성Article Published on 2021-10-052022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed antibodies antibody Clinical data consequence Control control group coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cross-reactivity Dengue Dengue fever dengue virus diagnosed domain ELISA ELISA testing envelope protein enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay epitope Epitopes False-positive healthy individual identify IgA IgG IgG antibodies IgM Immunoglobulin Immunoglobulin G immunoglobulin M Implications in-silico include individual Infection Laboratory features lead Patient Patient care performed positive Potential Protein public health Rapid test respiratory S protein SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes serology serum sample serum samples severe acute respiratory syndrome Coronavirus similarities similarity Spike protein Structural analysis subject Support tested the S protein the spike protein West West Nile [DOI] 10.1093/cid/ciaa1207 PMC 바로가기 [Article Type] Article
Temporal landscape of mutational frequencies in SARS-CoV-2 genomes of Bangladesh: possible implications from the ongoing outbreak in Bangladesh방글라데시 SARS-CoV-2 게놈의 돌연변이 빈도의 시간적 풍경: 방글라데시에서 진행 중인 발병의 가능한 의미Article Published on 2021-10-012022-09-11 Journal: Virus Genes [Category] SARS, 변종, 치료기술, 치료법, 치료제, [키워드] age Analysis association Bangladesh change circulating condition conserved country COVID-19 D614G D614G mutation envelope envelope protein Evolution facilitate Factor Frequency function Genome GISAID Helicase implication intrinsic majority Model molecular phylogeny Mutation N protein nonspecific NSP11 NSP2 Nsp3 Nsp9 nucleocapsid protein ORF ORF3a ORF7b outbreak P323L performed platform Protein protein structure RdRP reference genome S2 domain SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomic sequence SARS-CoV-2 genomic sequences SARS-CoV-2 propagation SARS-CoV-2 strain selective sequenced Sex Spike protein strain susceptibility Temporal the Spike unique Vaccine development [DOI] 10.1007/s11262-021-01860-x PMC 바로가기 [Article Type] Article
Betacoronavirus Assembly: Clues and Perspectives for Elucidating SARS-CoV-2 Particle Formation and EgressMinireview Published on 2021-09-282022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Betacoronavirus caused characterized coronavirus coronavirus disease COVID-19 death described disease egress envelope protein Formation glycoprotein humans in viral involved knowledge membrane membrane curvature molecular mechanism New coronavirus nucleocapsid protein pandemic virus Particle Pneumonia produced Protein question raised Replication responsible SARS-CoV-2 spike glycoprotein structural protein structural proteins viral assembly viral entry viral particle Wuhan, China [DOI] 10.1128/mBio.02371-21 PMC 바로가기 [Article Type] Minireview
GENERATING RESPONSES IMMUNE IN CELLULAR AND HUMORAL TREATMENT WITH EPITOPE SPIKE, EPITOPE ENVELOPE PROTEIN, AND EPITOPE MEMBRANE PROTEIN SARS-COV-2, HONEY, SAUSSUREA LAPPA , AND NIGELLA SATIVAArticle Published on 2021-09-012022-10-27 Journal: African Journal of Infectious Diseases [Category] COVID-19, [키워드] Sausseria lappa administration animal model Cellular immune response cellular immunity clinical trial COVID-19 CPE CTL domination envelope protein epitope evaluated four group four groups Honey humoral immune response Humoral immunity IgG IL-4 immunomodulator Indonesia lung marker material membrane protein mice Nigella Sativa NK cell NK cells organ pandemic PBS Placebo Research Respons immune Spike protein β-defensin [DOI] 10.21010/ajidv15i2S.3 PMC 바로가기 [Article Type] Article
GENERATING RESPONSES IMMUNE IN CELLULAR AND HUMORAL TREATMENT WITH EPITOPE SPIKE, EPITOPE ENVELOPE PROTEIN, AND EPITOPE MEMBRANE PROTEIN SARS-COV-2, HONEY, SAUSSUREA LAPPA , AND NIGELLA SATIVA에피토프 스파이크, 에피토프 봉투 단백질 및 에피토프 막 단백질 SARS-COV-2, Honey, Saussurea Lappa 및 Nigella Sativa로 세포 및 체액 처리에서 면역을 생성합니다.Article Published on 2021-09-012022-09-10 Journal: African Journal of Infectious Diseases [Category] 비임상, [키워드] Sausseria lappa administration animal model breath Cellular immune response cellular immune responses cellular immunity clinical trial COVID-19 CPE CTL domination envelope protein epitope evaluated four group four groups Honey humoral immune response Humoral immunity IgG IL-4 immune responses immunomodulator Indonesia lung marker material membrane protein mice mouth Nigella Sativa NK cell NK cells organ pandemic PBS Placebo Research Respons immune Spike protein TGF-β β-defensin [DOI] 10.21010/ajidv15i2S.3 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Antibody Isotypes in Systemic Lupus Erythematosus Patients Prior to Vaccination: Associations With Disease Activity, Antinuclear Antibodies, and Immunomodulatory Drugs During the First Year of the Pandemic예방 접종 전 전신 홍반성 루푸스 환자의 SARS-CoV-2 항체 아이소타입: 유행병 첫 해 동안 질병 활성, 항핵항체 및 면역조절 약물과의 연관성Immunology Published on 2021-08-272022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] a minor Activation activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 albumin all subjects analyzed anti-dsDNA antibodies antibody antibody isotypes Antibody Response antinuclear antibodies antinuclear antibody Arthritis Blood Blood Group BMI Cell cell receptor collected complement Complement activation complement-immunological terms coronavirus coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 COVID-19-related symptom dose drug Effects ELISA envelope protein exposure to Fever followed by glucocorticoid Hydroxychloroquine IgA IgG IgM Impact include individual Infection interferon investigated isotype longitudinal samples Lupus lupus (SLE) lupus erythematosus minor multiplex neutralization (effect of) neutralizing capacity objective pandemic Patient patients with SARS-CoV-2 PCR-confirmed progression proportion Proteins respiratory Result Rheumatic diseases rheumatologist risk SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection serological severe acute respiratory syndrome Coronavirus severe SARS severe SARS-CoV-2 SLE SLE patient smoking steroid Steroids subject Swedish Symptom systemic systemic lupus erythematosus the cell Thromboembolism type I interferon use of hydroxychloroquine vaccination were measured women Year [DOI] 10.3389/fimmu.2021.724047 PMC 바로가기 [Article Type] Immunology
MALDI-ToF protein profiling as a potential rapid diagnostic platform for COVID-19Research article Published on 2021-08-012022-10-05 Journal: Journal of Mass Spectrometry and Advances in the Clinical Lab [Category] 바이오마커, 변종, 진단, [키워드] liquid chromatography mass spectrometry ACE2angiotensin-converting enzyme 2 Analysis analyzed angiotensin-converting enzyme 2 area under the curve Asymptomatic AUCarea under the curve Biomarker Cohort Concordance controls Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 testing COVID-19coronavirus disease 2019 CT cycle threshold demonstrated develop diagnostic Diagnostic method dithiothreitol DTTdithiothreitol E Proteinenvelope protein Emergency use authorization envelope protein EUAemergency use authorization FDAFood and Drug Administration Food and Drug Administration human donor human serum IgAimmunoglobulin A IgGimmunoglobulin G IgMimmunoglobulin M immunoglobulin A Immunoglobulin G immunoglobulin M immunoglobulins inactivated LC-MS limit of detection limitation LoDlimit of detection M Proteinmembrane protein MALDI-ToF MSmatrix-assisted laser desorption/ionization-time of flight mass spectrometry matrix-assisted laser desorption/ionization-time of flight mass spectrometry membrane protein N Proteinnucleocapsid protein nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs Non-invasive NPnasopharyngeal nucleocapsid protein pilot study platform positive individuals Protein proteome RBDReceptor Binding Domain receiver operating characteristic Receptor binding domain Reverse transcriptase quantitative polymerase chain reaction Ribonucleic acid RNARibonucleic acid ROCreceiver operating characteristic RT-qPCR S Proteinspike protein Saliva SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 virus SARS-CoV-2severe acute respiratory syndrome coronavirus 2 sensitivity severe acute respiratory syndrome coronavirus 2 specificity specimen Spike protein VEPviral envelope protein viral envelope protein WHOWorld Health Organization with COVID-19 World Health Organization [DOI] 10.1016/j.jmsacl.2021.09.001 [Article Type] Research article
Screening Antibodies Raised against the Spike Glycoprotein of SARS-CoV-2 to Support the Development of Rapid Antigen AssaysArticle Published on 2021-07-272022-10-27 Journal: ACS Omega [Category] COVID-19, [키워드] antibody Antigen antigens Asymptomatic case Biomarker coronavirus Coronavirus-2 country cross-reactivity detection development diagnose Diagnosis diagnostic diagnostic test diagnostic tests diagnostic value disease early stage envelope protein group identify immunoassay immunoassays include infected case Infection lateral flow leading management membrane protein molecular monoclonal antibody nucleocapsid protein promote provided Rapid Rapid diagnostic test Research resources SARS-CoV-2 SARS-CoV-2 spike protein Screening sensitivity serologic serologic tests spike glycoprotein Spike protein Support Surveillance the Spike therapeutic Transmission viral pathogen [DOI] 10.1021/acsomega.1c01321 PMC 바로가기 [Article Type] Article
Determination of Ligand Binding Modes in Hydrated Viral Ion Channels to Foster Drug Design and Repositioning약물 디자인 및 재배치 촉진을 위한 수화된 바이러스 이온 채널의 리간드 결합 모드 결정Article Published on 2021-07-272022-09-10 Journal: Journal of Chemical Information and Modeling [Category] MERS, SARS, 신약개발, 치료제, [키워드] amantadine antiviral drug atomic resolution binding bridging interaction build candidate capture channel complex complex structure complexes COVID-19 pandemic derivative Determination determined by Diversity drug drug candidate drug design Drug discovery envelope protein experiment foster help hydrocarbon hydrophobic IMPROVE Influenza influenza A investigated Ion ion channel ion channels Ligand mechanism of action mode Numerous positioned protocol Region reliability repositioning resulting SARS-CoV-2 scratch Structure structures the SARS-CoV-2 transmembrane Undetermined water water molecules waters while [DOI] 10.1021/acs.jcim.1c00488 PMC 바로가기 [Article Type] Article