Nanoparticles in the diagnosis and treatment of vascular aging and related diseases Reviews Published on 2022-07-112022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 바이오마커, [키워드] advance adverse effect alteration cardiovascular diseases cellular cellular senescence cerebrovascular diseases chronic kidney diseases Diagnosis diagnostic disease Diseases Epigenetic events function knowledge less limitation mitochondrial dysfunction molecular Multiple nanoparticle Occurrence oxidative stress Phenotypes Prognosis structures therapeutic tissues Treatment Vascular vascular inflammation vasculature [DOI] 10.1038/s41392-022-01082-z [Article Type] Reviews
EWAS of post-COVID-19 patients shows methylation differences in the immune-response associated gene, IFI44L, three months after COVID-19 infectionObservational Study Published on 2022-07-072022-10-04 Journal: Scientific Reports [Category] 임상, 진단, 치료기술, 치료법, [키워드] Analysis ANKRD9 cellular processes Control Corona COVID-19 COVID-19 case COVID-19 infection Degradation DNA methylation Epigenetic FDR IFI44L IMPDH2 implicated innate response interferon investigated involved lack limitation long-COVID Methylation Ontology pathophysiology pathway Patient performed Peripheral blood positive individuals post-COVID-19 patient Post-infection predict profile Prognosis prospective observational study Sample size severity significant difference significantly Support Systemic autoimmune diseases therapeutic target variety viral infection viruses [DOI] 10.1038/s41598-022-15467-1 PMC 바로가기 [Article Type] Observational Study
A cautionary note on altered pace of aging in the COVID-19 era코로나19 시대 고령화 속도 변화에 대한 주의사항Article Published on 2022-07-012022-09-11 Journal: Forensic science international. Genetics [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] accumulated acute respiratory syndrome Affect age aging all-cause mortality Alter Blood chronological age Clinical research CLOCK confounder Corona virus coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 pandemic DNA methylation DNA methylation markers Effect Epigenetic Forensic Forensic age estimation heterogeneous nature Immune cell immune cells immune response individual individuals Interpretation joint life style management marker Modification modify molecular mortality risk pace pandemic pathogen Pathogens Pathologies pathology performed persistence Perturbation perturbations reliability Research respiratory risk SARS-CoV-2 SARS-CoV-2 pandemic scar Severe acute respiratory syndrome SjTREC syndrome T-cell receptor telomere Telomere Length the SARS-CoV-2 These data vaccination virus [DOI] 10.1016/j.fsigen.2022.102724 PMC 바로가기 [Article Type] Article
Identification of COVID-19-Associated DNA Methylation Variations by Integrating Methylation Array and scRNA-Seq Data at Cell-Type Resolution세포 유형 분해능에서 메틸화 어레이 및 scRNA-Seq 데이터를 통합하여 COVID-19 관련 DNA 메틸화 변이 식별Article Published on 2022-06-212022-09-11 Journal: Genes [Category] MERS, 바이오마커, [키워드] AHNAK antiviral activity biological processe Biomarker cell type cell types COVID-19 COVID-19 patient COVID-19 patients CX3CR1 Cytokines DNA DNA methylation DNAm variation gene Epigenetic FIVE identification immune immune dysfunction immune response immune responses Inflammatory response knowledge LFNG low expression lymphopenia Methylation methylation array phenomenon play roles pro-inflammatory cytokines regulated Regulation reported Resolution S100A9 scRNA-seq signaling pathways single-cell single-cell level specificity T cell T cells TRAF3IP3 Transcriptome Variation Whole blood [DOI] 10.3390/genes13071109 PMC 바로가기 [Article Type] Article
A systems biology approach identifies candidate drugs to reduce mortality in severely ill patients with COVID-19시스템 생물학 접근 방식으로 COVID-19 중증 환자의 사망률을 줄이기 위한 후보 약물 식별Article Published on 2022-06-032022-09-11 Journal: Science Advances [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus applied approach attribute candidate candidate drug caused coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 Critically ill Critically ill patient critically ill patients drug target drug treatment effective Epigenetic Hospital admission host response identify interferon interferon signaling lack Messenger RNA metabolism monocyte Mortality Nintedanib Ordinal Scale pathway Pathways Patient patients hospitalized reduce mortality RNA splicing SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severely ill patient severely ill patients Systems biology tacrolimus therapeutic transcriptomic Treatment Vaccines with COVID-19 Zotatifin [DOI] 10.1126/sciadv.abm2510 PMC 바로가기 [Article Type] Article
Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trialResearch article Published on 2022-05-122022-10-05 Journal: EClinicalMedicine [Category] 유전자 메커니즘, 임상, [키워드] 1:1 95% CI analyses Analysis BCG BCG vaccination Breastfeeding Cape Capital childhood computation computing Council COVID-19 COVID-19 testing died Donor double-blind Dream Efficacy enrolled Epigenetic evaluated Evidence female finding FIVE foundation functional funding had no hazard ratio healthcare healthcare worker hospitalisation hypersensitivity hypothesised Immunocompromised Infrastructure innate immune system introduced Investment IQR median age medical doctors morbidity morbidity and mortality non-specific Nurses occurred pandemic participant phase 3 trial placebo-controlled trial pregnant Prevent PROTECT provided randomised recruited reduction Registered resource respiratory tract infection Respiratory tract infections Safety SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease severity South Africa statistically significant Swedish Symptoms the placebo group trained immunity Treatment Tuberculosis Vaccine were assessed [DOI] 10.1016/j.eclinm.2022.101414 [Article Type] Research article
Accelerated biological aging in COVID-19 patients Research Published on 2022-04-192022-10-05 Journal: Nature Communications [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] accelerated addition age attrition blood sample calculated chronological age contribute correlation COVID-19 COVID-19 patient DNA methylation EpiC Epigenetic groups healthy individual in viral infected patient Infection Methylation observé patients profiling analysis reversed risk risk factor SARS-COV-2 infection severe COVID-19 Survivors syndrome [DOI] 10.1038/s41467-022-29801-8 [Article Type] Research
Characterization of Altered Gene Expression and Histone Methylation in Peripheral Blood Mononuclear Cells Regulating Inflammation in COVID-19 PatientsCOVID-19 환자의 염증을 조절하는 말초 혈액 단핵 세포에서 변경된 유전자 발현 및 히스톤 메틸화의 특성화Article Published on 2022-04-152022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] 유전자 메커니즘, [키워드] alteration Altered Analysis approved arginase Bone marrow cause caused characterization chromosome correlated COVID-19 COVID-19 disease COVID-19 patients COVID-19 treatment Cytokines death Dexamethasone dysregulated Epigenetic expression expression pattern expression patterns expressions gene expression profile Gene expression profiles Genes healthy control healthy controls histone histone methylation hospitalized COVID-19 patient hospitalized COVID-19 patients IL-1 IL-17 IL-1B IL-6 indicated Inflammation information inhibitor investigated kinase kinases long noncoding RNA majority mechanisms member Methylation miRNA pandemic of COVID-19 pathway Pathway analysis Pathways PBMC PBMCs peripheral Potential biomarker potential biomarkers proinflammatory cytokines protein S provide receptor Regulating Regulation significantly target targets TEC TGF-β therapeutic target therapeutic targets treat Treatment upregulated variations von Willebrand factor was increased [DOI] 10.4049/jimmunol.2101099 PMC 바로가기 [Article Type] Article
The INDEPTH (Impact of Nuclear Domains on Gene Expression and Plant Traits) Academy: a community resource for plant scienceINDEPTH(유전자 발현 및 식물 특성에 대한 핵 도메인의 영향) 아카데미: 식물 과학을 위한 커뮤니티 리소스Article Published on 2022-04-052022-09-11 Journal: Journal of experimental botany [Category] 유전자 메커니즘, [키워드] Academy Action Analysis automated Community community resource Control COST Action COVID-19 pandemic deep learning driven by engage Epigenetic epigenetics Gene Expression growth image repository Impact Laboratory nuclear nucleus Open Access plant plants produced protocols provide recent Repository researcher resource resources Standardization standardized protocols Support tutorials webinars. [DOI] 10.1093/jxb/erac005 PMC 바로가기 [Article Type] Article
Repurposing Multiple-Molecule Drugs for COVID-19-Associated Acute Respiratory Distress Syndrome and Non-Viral Acute Respiratory Distress Syndrome via a Systems Biology Approach and a DNN-DTI Model Based on Five Drug Design Specifications5가지 약물 설계 사양을 기반으로 하는 시스템 생물학 접근법 및 DNN-DTI 모델을 통한 COVID-19 관련 급성 호흡곤란 증후군 및 비바이러스성 급성 호흡곤란 증후군에 대한 다분자 약물 용도 변경Article Published on 2022-03-262022-09-11 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 바이오마커, 신약개발, 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome advance AIC Akaike information criterion approach ARDS Biology Biomarker Biomarkers candidate drug candidate drugs clinical manifestation clinical manifestations convenience coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19-associated ARDS criterion database deep neural network drug drug candidate drug design drug target drug-likeness drug-target DTI model Epidemic Epigenetic etiologic mechanism excretion False positive False positives Genetic help host-pathogen RNA-Seq data HPI-GWGEN information Interaction KEGG mechanism Mitigation Model morbidity morbidity and mortality non-viral ARDS Pathogenesis pathogenic pathophysiology pathway Pathways PNP predict predicted Regulation repurposing respiratory respiratory distress RNA sequencing SARS-CoV-2 sensitivity signaling pathway specification syndrome System Systems biology therapeutic option Therapeutic treatment Toxicity [DOI] 10.3390/ijms23073649 PMC 바로가기 [Article Type] Article