Immunoinformatics Analysis of SARS-CoV-2 ORF1ab Polyproteins to Identify Promiscuous and Highly Conserved T-Cell Epitopes to Formulate Vaccine for Indonesia and the World PopulationArticle Published on 2021-12-092022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Algorithms allele Antigen caused class conserved contribute Coverage COVID-19 pandemic criteria CTL cytotoxic T-cells docking epitope epitope mapping FIVE helper T-cells HLA HLA-A*24:07 HTL human leukocyte antigen IFNγ immunoinformatics in vitro study Indonesia Infection leukocyte linkers Microbiome multi-epitope peptide-based vaccine ORF1ab peptide peptides physicochemical characteristics Population predominant Protective reducing reflected Region responses SARS-CoV-2 shown stimulate Symptom T-cell T-cell epitopes T-cell Response the vaccine TLR4 toll-like receptor 4 vaccine construct Vaccine design variant β-defensin [DOI] 10.3390/vaccines9121459 PMC 바로가기 [Article Type] Article
High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19Article Published on 2021-11-222022-10-04 Journal: Communications Biology [Category] MERS, SARS, 바이오마커, 변종, 진단, [키워드] Adaptive immunity analyzed antibody epitopes Antibody Response Antigen applied approach Bacterial binding coronavirus 2 Coronaviruses COVID-19 cross-reactive D614G Data mining data-driven Diagnostic markers disease severity dominant epitope effective vaccine elicit epitope epitope mapping Evolution of SARS-CoV-2 highlight humoral identify immune response in silico analysis infected patient large cohort Mild motif mutant Mutant SARS-CoV-2 neutralization activity organism other coronavirus Patient peptide platform proteome proteomes random reduced Region repertoire respiratory SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 epitope SARSCoV-2 serum samples severe disease specificity Spread Strains subject the vaccine Therapies therapy treat viral infection with COVID-19 [DOI] 10.1038/s42003-021-02835-2 PMC 바로가기 [Article Type] Article
Epitope mapping from Mycobacterium leprae proteins: Convergent data from in silico and in vitro approaches for serodiagnosis of leprosyarticle Published on 2021-10-312024-09-01 Journal: Molecular Immunology [Category] 한센병, [키워드] epitope mapping Immunodiagnosis immunoinformatics in silico prediction leprosy synthetic peptide [Article Type] article
SARS-CoV-2 Antibody Binding and Neutralization in Dried Blood Spot Eluates and Paired Plasma건혈 반점 용출액 및 짝을 이루는 혈장에서 SARS-CoV-2 항체 결합 및 중화Research Article Published on 2021-10-202022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 진단, [키워드] 384-well format acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adoption ambient ambient temperature antibodies antibody Antibody binding Antibody Response Antibody responses binding Blood cold chain cold temperatures collected convalescent coronavirus correlated COVID-19 COVID-19 pandemic Critical dried blood spot Dried blood spots ELISA Eluate enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay epitope epitope mapping equipment evaluate feature fingerstick immune response immune responses Infection invasive Longevity MOST natural infection neutralization assays Neutralizing antibodies neutralizing antibody overcome phage display plasma plasma antibody Population profile reflected respiratory responses risk SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody response SARS-CoV-2 antibody responses SARS-CoV-2 neutralization SARS-CoV-2 variant sera severe acute respiratory syndrome Coronavirus specific antibodies spot storage Support temperature vaccinated individuals vaccination variety venipuncture venous venous blood while [DOI] 10.1128/Spectrum.01298-21 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 specific memory T cell epitopes identified in COVID-19-recovered subjectsSARS-CoV-2 특정 기억 T 세포 에피토프가 COVID-19 회복 대상에서 확인됨Article Published on 2021-10-152022-09-11 Journal: Virus research [Category] SARS, 치료법, [키워드] Activation Analysis B cell caused CD4 CD8 T cell Cell Coronaviral COVID-19 COVID-19 pandemic COVID-19 vaccine design defined ELISPOT enzyme enzyme-linked immunosorbent epitope epitope mapping Epitopes evaluated examined explicit flow cytometry followed by foundation glycoprotein HLA Hope host immunity IgG immune immune responses immunodominant epitopes immunogenic immunogenicity in some individual induce mapped memory T memory T cells mononuclear cell N protein neutralizing antibody Neutralizing antibody response neutralizing antibody responses nucleocapsid nucleoprotein Outbreaks PBMCs peptide peptides Peripheral blood Peripheral blood mononuclear cells positively correlated proportion protective immunity Protein public health RBD receptor Receptor-binding domain Reinfection response robust S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S spike spike glycoprotein stimulate structural proteins subject subjects T cell T cell activation T cell epitope T cell epitopes T cell response T cell responses T cells the receptor-binding domain the S protein Therapeutics vaccination Vaccine Vaccine design virus-specific T cell virus-specific T cell responses were used [DOI] 10.1016/j.virusres.2021.198508 PMC 바로가기 [Article Type] Article
Immunodominant linear B cell epitopes in the spike and membrane proteins of SARS-CoV-2 identified by immunoinformatics prediction and immunoassay면역정보학 예측 및 면역분석으로 확인된 SARS-CoV-2의 스파이크 및 막 단백질의 면역우성 선형 B 세포 에피토프Article Published on 2021-10-142022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, [키워드] Amino acid amino acid change amino acid changes Analysis B cell B cell epitope B cell epitopes C-terminus Computational biology and bioinformatics convalescent sera COVID-19 infected patients death decrease Efficacy ELISA ENhance epitope epitope mapping Epitopes greater highlighting immunoassay immunodominant immunodominant epitopes immunoinformatics immunology IMPROVE increase in infect infected patients linear linear B M protein membrane membrane protein Microbiology NTD number of deaths predicted Protein provide RBD Region resulting S1/S2 cleavage site S2 domain SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike receptor-binding domain SARS-CoV-2 vaccine sera spike receptor-binding domain subunit Subunit vaccine the SARS-CoV-2 Vaccine Vaccine design vaccine efficacy variants variants of concern Viral [DOI] 10.1038/s41598-021-99642-w PMC 바로가기 [Article Type] Article
Preclinical evaluation of a synthetic peptide vaccine against SARS-CoV-2 inducing multiepitopic and cross-reactive humoral neutralizing and cellular CD4 and CD8 responses다에피토프 및 교차 반응성 체액 중화 및 세포 CD4 및 CD8 반응을 유도하는 SARS-CoV-2에 대한 합성 펩타이드 백신의 전임상 평가Research Article Published on 2021-09-272022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 진단, [키워드] adjuvant alum Amino acid antibody Antibody Response B-cell epitopes BALB/c CD4 CD8 cellular cellular immunity characterization CpG cross-reactive cysteine cysteines displaying dose epitope epitope mapping Epitopes experiment Freund’s Freund’s adjuvant generate hACE2 HLA humanized humoral identification identify immunization infected individual infected individuals K18-hACE2 mice lethal dose linear epitope linear epitopes mice Neutralizing Neutralizing antibodies neutralizing capacity overlapped peptide peptide vaccine peptides Preclinical Protein Proteins RBD Receptor-binding domain recognizing response S protein S proteins SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants sera subunit suggested T-cell epitopes tested the receptor-binding domain titres transgenic mice vaccination Vaccine vaccine platform [DOI] 10.1080/22221751.2021.1978823 PMC 바로가기 [Article Type] Research Article
Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunizationResearch Article Published on 2021-07-282022-10-28 Journal: Science Advances [Category] Coronavirus, SARS, [키워드] antibodies antibody approach Critical degrade driven by elicit elicited epitope epitope mapping Epitopes glycoprotein HIV immunization immunogen Influenza iterative Microscopy Neutralizing Neutralizing antibodies neutralizing antibody polyclonal prefusion conformation Protein protein subunit vaccine provide responses RSV SARS-CoV-2 subunit Subunit vaccine target trimer trimeric Vaccine Vaccine design variety viral surface virus while [DOI] 10.1126/sciadv.abh2791 PMC 바로가기 [Article Type] Research Article
Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutantsArticle Published on 2021-07-202022-10-04 Journal: Cell Discovery [Category] 변종, [키워드] acute respiratory syndrome antibody antibody cocktail caused Coronaviral coronavirus Coronavirus disease 2019 COVID-19 Cryo-electron microscopy Cryoelectron microscopy death effective eliminated epitope epitope mapping evade experiment group involved Measures mice mutant Mutation neutralize Neutralizing Neutralizing antibodies neutralizing antibody pandemic disease Pattern recognition receptors performed provide RBD residue SARS-CoV-2 strain the receptor-binding domain therapeutic Threats variant [DOI] 10.1038/s41421-021-00292-z PMC 바로가기 [Article Type] Article
Landscape and selection of vaccine epitopes in SARS-CoV-2Research Published on 2021-06-142022-10-31 Journal: Genome Medicine [Category] COVID-19, MERS, SARS, [키워드] ADE analyses Antibody-dependent enhancement avoidance B cell B cell epitopes B cell responses candidate vaccine Candidates CD4 CD8 Cell cellular immunity conformational convalescent COVID-19 patient convalescent patient Coverage COVID-19 curated dataset decrease domain Effect eight ELISA ELISPOT epitope epitope mapping Epitopes Frequency functional glycosylation HLA alleles humoral Humoral response initial landscape ligands linear MHC MHC-I MHC-II murine overlap pandemic peptide peptides predicted Protective Protein Region Result SARS-CoV-2 SARS-CoV-2 peptide vaccine SARS-CoV-2 vaccine selected selection process sequence Sequence conservation serum spatial localization specificity spike glycoprotein Strong subsequent supplementary material T cell T cell epitope T cell response vaccination Vaccine vaccine candidate [DOI] 10.1186/s13073-021-00910-1 PMC 바로가기 [Article Type] Research