The N-Terminal Region of Middle East Respiratory Syndrome Coronavirus Accessory Protein 8b Is Essential for Enhanced Virulence of an Attenuated Murine CoronavirusPathogenesis and Immunity Published on 2021-11-242022-10-30 Journal: Journal of Virology [Category] COVID-19, MERS, [키워드] Accessory accessory protein accessory protein 8b accessory proteins addition Affect antiviral immune response beta coronavirus C-terminal contribute coronavirus CoV CoVs demonstrated ENCODE Endoplasmic reticulum ENhance enhanced Essential expressing FIVE Genome global public health Hepatitis high variability Host IFN-I in vitro in vivo infected cells inhibit inhibitory effect innate immune response Innate immunity interfere introduced membrane MERS-CoV MERS-CoV infection methionine MHV mice Middle East mouse mouse hepatitis virus Multiple murine N-terminal domain not affect ORF8b Pathogenesis Protein protein 3 Region regulate renal Replication respiratory respiratory syndrome coronavirus responsible RNA-seq analysis SARS-CoV SARS-CoV-2 severe pneumonia severe respiratory infection shown significantly threat type I interferon variant viral replication Viral virulence virulence virus [DOI] 10.1128/JVI.01842-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity
Antiviral Activities of Eucalyptus Essential Oils: Their Effectiveness as Therapeutic Targets against Human VirusesReview Published on 2021-11-232022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] 1,8-cineole activity addition Anti-inflammatory Antiviral antiviral activity antiviral therapy binding caused complement complementary Effect Effectiveness Essential Eucalyptus eucalyptus essential oil H1N1 influenza virus herpes simplex virus host cell Human inactivation Infection Infectious disease Inflammatory response Influenza involved management molecular mechanism penetration pharmacological target respiratory diseases SARS-CoV-2 shown Symptom target therapeutic Treatment Vaccine viral infection Viral protein viruses [DOI] 10.3390/ph14121210 PMC 바로가기 [Article Type] Review
Effect of the COVID-19 Pandemic Preparation and Response on Essential Health Services in Primary and Tertiary Healthcare Settings of Amhara Region, EthiopiaArticle Published on 2021-11-202022-10-28 Journal: The American Journal of Tropical Medicine and Hygi [Category] COVID-19, [키워드] analyzed Antenatal average Care childhood clinical evaluation country COVID-19 COVID-19 case COVID-19 pandemic cross-sectional Diabetic dropped Effect Essential family Follow-up Health Health Service healthcare service highlight HIV patient hypertension independent measure mitigate Patient preparation Region reported response selected service setting Seven significantly Tertiary Tuberculosis [DOI] 10.4269/ajtmh.21-0354 PMC 바로가기 [Article Type] Article
An Evaluation of the Potential of Essential Oils against SARS-CoV-2 from In Silico Studies through the Systematic Review Using a Chemometric ApproachSystematic Review Published on 2021-11-102022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] Analysis anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral antiviral activity binding affinity Bioactivity Cedrus libani Compound compounds COVID-19 drug drug-likeness effective eligibility criteria eligible Essential essential oil Eugenia evaluated help hierarchical cluster analysis (HCA) highest identify in vitro in vivo Oil pharmacokinetic physicochemical plant species Potential predicted reported retrieved review SARS-CoV-2 Seven systematic literature search target proteins Toxicity volatile compound Zataria Zingiber [DOI] 10.3390/ph14111138 PMC 바로가기 [Article Type] Systematic Review
The NF-κB Transcriptional Footprint Is Essential for SARS-CoV-2 ReplicationNF-κB 전사 발자국은 SARS-CoV-2 복제에 필수적입니다Article Published on 2021-11-092022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘, [키워드] absence Activation Analysis Antiviral approach canonical caused characterized COVID-19 COVID-19 pandemic cytokine production Defense dependency develop Disruption driving effective antiviral treatment effective vaccine Effective vaccines effort Essential etiological agent Factor Footprint IFN-I IFN-I response in vitro infected cells inhibitors molecular basis morbidity Mortality new SARS-CoV-2 NF-κB NF-κB signaling P50 p65 product reduced rescued robust SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 replication screenings selective single-cell These data transcription factor transcription factors transcriptomic type I interferon variant viral replication virus replication [DOI] 10.1128/JVI.01257-21 PMC 바로가기 [Article Type] Article
COVID-19 Vaccination Coverage, Intent, Knowledge, Attitudes, and Beliefs among Essential Workers, United StatesDispatch Published on 2021-11-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] Attitudes belief coronavirus coronavirus disease COVID-19 Essential essential worker Essential workers highlighting intent knowledge lack perceptions reported respiratory infections SARS SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Side effects United State United States vaccination Vaccine Vaccines viruses zoonoses [DOI] 10.3201/eid2711.211557 PMC 바로가기 [Article Type] Dispatch
Clarifying the Use of Benzylidene Protecting Group for D-(+)-Ribono-1,4-Lactone, an Essential Building Block in the Synthesis of C -NucleosidesArticle Published on 2021-10-262022-10-30 Journal: Molecules [Category] Coronavirus, MERS, SARS, [키워드] 1-C-substituted nucleosides addition analogues antiviral activity antiviral drug block building carbohydrate Clarifying Community Compound compounds condition COVID-19 cyclic acetals DMSO Essential global pandemic group molecular NMR nucleoside Protecting protecting groups reaction ribono-1,4-lactone Scientific community Spread structural rearrangement subject Support synthesis these compound [DOI] 10.3390/molecules26216447 PMC 바로가기 [Article Type] Article
Incidence of SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential Workers During a Prevaccination COVID-19 Surge in ArizonaResearch Published on 2021-10-222022-10-30 Journal: JAMA Health Forum [Category] COVID-19, MERS, SARS, [키워드] 95% CI adjusted age Analysis Care Cohort cohort study Community comparable confounder confounding factors Contact COVID-19 COVID-19 pandemic COVID-19 vaccine defined elevated Enrollment Essential essential worker Essential workers exposure finding first positive generate greater Guidance Health Health status Hispanic Importance incidence incidence rate individuals Infection infection risk measure multivariable model nasal swab negative objective operator Other participant performed Point polymerase chain prevaccination prospective cohort study PROTECT public health real-time reverse transcriptase Relevance remained Research Responder responders Result risk SARS-CoV-2 SARS-COV-2 infection seronegative setting significantly higher Sociodemographic characteristics specimen study cohort submitted understanding was used while white worker [DOI] 10.1001/jamahealthforum.2021.3318 PMC 바로가기 [Article Type] Research
Detection of respiratory viruses in adults with suspected COVID-19 in Kuala Lumpur, MalaysiaArticle Published on 2021-10-202022-10-04 Journal: Journal of Clinical Virology [Category] MERS, SARS, 치료기술, [키워드] accounted Adults Analysis ARI assays circulation Co-infection collected COVID-19 COVID-19 pandemic COVID-19 patient described detection died Enterovirus D68 Essential FIVE Genotype hospital Hospitalization ICU care identify incidence information Malaysia measure metagenomics Mild symptom MOST negative sample objective Panel Pathogens Patient patients hospitalized positive public health report respiratory Respiratory pathogens respiratory sample respiratory virus respiratory viruses Result Saffold virus SARS-CoV-2 Surveillance Swab tested viral metagenomics virus [DOI] 10.1016/j.jcv.2021.105000 PMC 바로가기 [Article Type] Article
Assessment of the Burden of SARS-CoV-2 Variants of Concern Among Essential Workers in the Greater Toronto Area, Canada캐나다 토론토 광역 지역의 필수 근로자들 사이에서 우려되는 SARS-CoV-2 변종의 부담 평가Observational Study Published on 2021-10-192022-09-10 Journal: JAMA Network Open [Category] MERS, SARS, 변종, 임상, [키워드] assessment burden Canada city cohort study concern Essential essential worker Greater Toronto Area income Peel Region SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Toronto worker [DOI] 10.1001/jamanetworkopen.2021.30284 PMC 바로가기 [Article Type] Observational Study