Network-based repurposing identifies anti-alarmins as drug candidates to control severe lung inflammation in COVID-19네트워크 기반의 재구성은 항-알라민을 COVID-19에서 심각한 폐 염증을 조절하기위한 약물 후보로 식별합니다.Research Article Published on 2021-07-222022-09-10 Journal: PLoS ONE [Category] 신약개발, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome airway alarmin alarmins alleviate Analysis approach C5a Consequences COVID-19 cytokine Cytokine release syndrome Cytokine storm Dexamethasone drug drug candidate endothelial cells epithelial Estrogen Estrogens Evolution Health Health services identify IL17 IL1β IL23 IL33 IL6 immune dysregulation Immunity inception incidence Inflammation inhibitor inhibitors JAK2 less Lung inflammation Other respiratory viruses Predictive Prevent progression Protein RAGE receiving receptor receptors reducing respiratory respiratory distress Respiratory distress syndrome respiratory viruses SARS-CoV-2 SARS-CoV-2 vaccines severe COVID-19 severe lung inflammation ST2 Support syndrome target targets the cytokine storm therapeutic therapeutic drug These data TNFα transition Treatment TSLP while [DOI] 10.1371/journal.pone.0254374 PMC 바로가기 [Article Type] Research Article
The effect of estrogen in coronavirus disease 2019Review Published on 2021-07-012023-07-01 Journal: American journal of physiology. Lung cellular and [Category] SARS, [키워드] COVID-19 Estrogen immune response SARS-CoV-2 Sex difference [DOI] 10.1152/ajplung.00332.2020 PMC 바로가기 [Article Type] Review
Estrogen Receptor Modulators in Viral Infections Such as SARS−CoV−2: Therapeutic ConsequencesReview Published on 2021-06-182022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] Activation addition caused complex consequence coronavirus COVID-19 cytokine Cytokine storm Effect Estrogen estrogen receptor females Hormones Hypothesis IL-6 include inhibit Interaction knowledge male modulator Mortality organism pandemic patient’s death protective effect receptor complex Respiratory disease responsible SARS−CoV−2 severe disease progression the cytokine storm therapeutic viral replication while [DOI] 10.3390/ijms22126551 PMC 바로가기 [Article Type] Review
COVID-19 pandemic: what about the gonads?COVID-19 전염병: 생식선은 어떻습니까?Review Published on 2021-06-012022-09-11 Journal: Hormones (Athens, Greece) [Category] SARS, 유전자 메커니즘, [키워드] accumulating addition Affect affected alcohol androgen angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 both sexes concerning country COVID-19 disease enzyme Estrogen Evidence Fertility functions Gender genders Genetic Gonads immunological indicate infecting Interaction mechanism organ organs question SARS-CoV-2 SARS-COV-2 infection Serine serine protease severity Sex smoking spread to Steroids supported the disease transmembrane serine protease transmembrane serine protease 2 Treatment [DOI] 10.1007/s42000-021-00277-3 PMC 바로가기 [Article Type] Review
Sex-Disaggregated Data on Clinical Characteristics and Outcomes of Hospitalized Patients With COVID-19: A Retrospective StudyCellular and Infection Microbiology Published on 2021-05-262022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] age analyzed ARDS association cause China clinical Clinical characteristics clinical manifestation Comorbidity confirmed case coronavirus disease COVID-19 death disease Estrogen female patient Female patients females Gender hospital hospitalized patient indicated Inflammatory response information Laboratory Logistic regression analysis lymphopenia male Menopause no significant difference organ damage outcome outcomes parameters Patient patients patients with COVID-19 premenopausal female propensity score matching PSM Radiographic real-time RT-PCR Result retrospective SARS-CoV-2 secondary bacterial infection Sex variable was used with COVID-19 [DOI] 10.3389/fcimb.2021.680422 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
COVID-19 in Africa: an ovarian victory?아프리카의 코로나19: 난소의 승리?Review Published on 2021-05-212022-09-12 Journal: Journal of Ovarian Research [Category] 진단, [키워드] acute respiratory syndrome coronavirus Africa African age anti-inflammatory cytokines antibody production attack black case study Caucasian Caucasians caused characterized coagulation disorder coagulation disorders Cohort contribute coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Cytokine storm Cytokines death rate death rates downregulation elevated Endoplasmic reticulum Estrogen fatality female genetics Hospitalization immune immunological incidence infections information mortality rate mortality rates offer outcome ovarian Ovary Pandemics Pneumonia predicted Pro-inflammation cytokine public health Racial respiratory Respiratory system SARS-CoV-2 SARS-CoV-2 infections Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant difference Stress the SARS-CoV-2 women [DOI] 10.1186/s13048-021-00820-1 PMC 바로가기 [Article Type] Review
Immunological aspects and gender bias during respiratory viral infections including novel Coronavirus disease‐19 (COVID‐19): A scoping reviewReview Published on 2021-05-192022-11-01 Journal: Journal of medical virology [Category] COVID-19, [키워드] adaptive immune responses antibodies autoimmune disorder Cell cellular clearance COVID‐19 detrimental discrepancy disease severity effective Estrogen evidenced exaggerated immune response exhibited female females Gender gender biasness hormone Host Human immune system Humoral immunity immune response immune system immunological Infection Inflammation inflammatory disease Inflammatory response less male males microbe novel pathogen Pathogens Patient respiratory infection respiratory viral respiratory viral infection responsible restrict SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 severity Sex difference sex hormone Sex hormones Spread T lymphocytes unique [DOI] 10.1002/jmv.27081 PMC 바로가기 [Article Type] Review
The Looming Effects of Estrogen in Covid-19: A Rocky RolloutNutrition Published on 2021-03-182022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] addition Angiotensin converting enzyme-2 Anti-inflammatory clinical outcomes clinical trial coronavirus disease coronavirus diseases COVID-19 database determinant factor Effect Estrogen expected explain finding Gender Google Scholar immuno-modulatory effect immunomodulating immunomodulatory effect independent risk factor Infection Intensive Looming mechanism men MERS-CoV Middle East modulation pandemic Pathways patients outcomes performed predisposition pro-inflammatory signaling Prospective Study protective effect reduce respiratory SARS-CoV SARS-CoV-2 severity sex hormone subject the disease viral infections Web of Science women [DOI] 10.3389/fnut.2021.649128 PMC 바로가기 [Article Type] Nutrition
The Double Edge Sword of Testosterone’s Role in the COVID-19 PandemicCOVID-19 팬데믹에서 테스토스테론의 역할이라는 양날의 검Review Published on 2021-03-162022-09-11 Journal: Frontiers in Endocrinology [Category] MERS, 유전자 메커니즘, [키워드] ACE2 age age-related co-morbidities complex COVID-19 Deterioration disease Disease progression edge Estrogen Evidence examination expansion Factor focus Gender Genetic Health Hormones human body hypogonadism Infection male mechanism mechanisms morbidities morbidity mortalities Mortality MPRSS2 Pathogenesis Prevalence question role SARS-CoV-2 SARS-COV-2 infection severity Sex hormones Spread Sword Testosterone [DOI] 10.3389/fendo.2021.607179 PMC 바로가기 [Article Type] Review
SARS-Cov2 S Protein Features Potential Estrogen Binding SitePreliminary Communications Published on 2021-03-012022-10-31 Journal: Food Technology and Biotechnology [Category] COVID-19, [키워드] 3D structure Affect appear approach average binding binding site compare protein conserved contribute coronavirus domain Epidemics estradiol Estrogen estrogen binding site estrogen receptor Fatality rate feature Hopefully immune response Infection involved membrane fusion men MERS notable pandemic Potential Proteins receptor reducing Result S protein SARS-CoV2 sequence severity similarity Site Surface glycoprotein Symptom the Coronaviridae the disease the S protein virus infectivity women [DOI] 10.17113/ftb.59.01.21.6820 PMC 바로가기 [Article Type] Preliminary Communications