Mesenchymal stem/stromal cell-based therapies for COVID-19: First iteration of a living systematic review and meta-analysis: MSCs and COVID-19COVID-19에 대한 중간엽 줄기/기질 세포 기반 치료법: 살아있는 체계적인 검토 및 메타 분석의 첫 번째 반복: MSC 및 COVID-19Meta-Analysis Published on 2022-06-012022-09-11 Journal: Cytotherapy [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI 95% confidence interval acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adherence adverse effects Analysis appear case sery Cell Cell-based therapy Clinical outcome Control coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 criteria Critical determine Efficacy Endpoint estimate Exosomes Extracellular Extracellular vesicles Follow-up Future heterogeneity immunomodulatory interleukin-6 ISCT iteration Mesenchymal stem cells Mesenchymal stromal cells Meta-analysis Microvesicles moderate Mortality MSC MSCs nine not performed Other outcome Other outcomes pandemic patients patients with COVID-19 performed Pneumonia potential risk primary analysis random-effect random-effects repeated reported respiratory distress Respiratory distress syndrome risk risk of bia risk of death risk ratio RoB SARS-CoV-2 Secondary outcomes secreted Sepsis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 standardized mean difference Statistical power stromal cells Study design systematic review therapy for COVID-19 tissue repair treat [DOI] 10.1016/j.jcyt.2021.12.001 PMC 바로가기 [Article Type] Meta-Analysis
Pivoting Novel Exosome-Based Technologies for the Detection of SARS-CoV-2SARS-CoV-2 검출을 위한 새로운 엑소좀 기반 기술 활용Review Published on 2022-05-182022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acceleration Accessibility Accuracy approach approaches biochemical Biomarker cell-to-cell communication commercialization COVID-19 Critical detection diagnosis of COVID-19 diagnostic diagnostics ENhance EVs Exosome Exosomes Extracellular extracellular vesicle Extracellular vesicles focus implementation infectious agents Isolation molecular NIH novel physical Radical RADx Rapid SARS-CoV-2 SARS-CoV-2 viral infection SARS-CoV-2 virus subpopulation surveillance testing technology Viral viral infection [DOI] 10.3390/v14051083 PMC 바로가기 [Article Type] Review
Rapid Optical Biosensing of SARS-CoV-2 Spike Proteins in Artificial Samples인공 샘플에서 SARS-CoV-2 스파이크 단백질의 신속한 광학 바이오센싱Article Published on 2022-05-162022-09-11 Journal: Sensors (Basel, Switzerland) [Category] COVID19(2023년), SARS, 치료기술, [키워드] 3,3'-diaminobenzidine amplification antibody applied artificial artificial saliva biosensor classic Concentration DAB defined detect domain ECD electron microscopy enzyme substrate evaluate Extracellular fiber fiber-optic biolayer interferometry Guidance highlight horseradish peroxidase HRP incidence Infection limit of detection mass mass surveillance Microscopy morphology nucleic acid nucleic acid test peroxidase precipitate Rapid rapid detection RBD Receptor-binding domain Saliva Sample SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 spike proteins scanning electron microscopy secondary antibody SEM sensitivity serum signal amplification spike Spike proteins substrates Surveillance Test [DOI] 10.3390/s22103768 PMC 바로가기 [Article Type] Article
Development of SARS-CoV-2 variant protein microarray for profiling humoral immunity in vaccinated subjects백신 접종 대상체의 체액성 면역 프로파일링을 위한 SARS-CoV-2 변이 단백질 마이크로어레이 개발Article Published on 2022-05-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 anti-spike antibody antibody Antibody responses AZD1222 B.1.1.7 B.1.351 B.1.617 B.1.617.1 B.1.617.2 binding ChAdOx1 chimeric collected correlated D614G demonstrated develop development domain Drug development Extracellular globe host receptor Humoral immunity Humoral response humoral responses IgA IgG IgM isotype IgM isotypes immune inhibiting Microarray MONITOR mRNA-1273 mutant neutralization neutralizing activities Neutralizing activity neutralizing antibody P.1 platform Protein protein microarray Research SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants serology serum spike variants subject the antibody response vaccinated individual vaccination Vaccine Vaccines variant variants variants of concern Virus neutralization wild-type [DOI] 10.1016/j.bios.2022.114067 PMC 바로가기 [Article Type] Article
Off-the-shelf CAR natural killer cells secreting IL-15 target spike in treating COVID-19 Research Published on 2022-05-112022-10-05 Journal: Nature Communications [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료법, 치료제, [키워드] ACE2 Allogeneic CAR Cell chimeric chimeric antigen receptor COVID-19 cytotoxicity Diseases domain experiments Express expressing Extracellular human ACE2 IFN-γ IL-15 immune in vitro in vivo Infection Intervention live SARS-CoV-2 maintain natural killer natural killer cell NK cell NK cells Patient reduce SARS-CoV-2 SARS-CoV-2 spike protein secreting subunit survival the spike protein therapy therapy for COVID-19 TNF-α transgenic mice treating COVID-19 Treatment Viral load viral particle [DOI] 10.1038/s41467-022-30216-8 [Article Type] Research
Elucidating Design Principles for Engineering Cell-Derived Vesicles to Inhibit SARS-CoV-2 InfectionSARS-CoV-2 감염을 억제하기 위해 세포 유래 소포를 엔지니어링하기 위한 설계 원리 설명Article Published on 2022-05-012022-09-11 Journal: Small (Weinheim an der Bergstrasse, Germany) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus addition administration antiviral efficacy binding affinities clinic coronavirus decoy decoys develop drug resistance Engineering evade Extracellular Extracellular vesicles feature foundation Health inhibit inhibitor inhibitors knowledge mAb mAbs monoclonal antibody nanovesicles. neutralization overcome Particle pathogen Pathogens principle provide Quantitative Recombinant protein repeated respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 virions sera several variant several variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sustained Therapeutics therapy Toxicity Vesicle vesicles Viral viral infections virions [DOI] 10.1002/smll.202200125 PMC 바로가기 [Article Type] Article
Therapeutic antibodies – natural and pathological barriers and strategies to overcome them치료 항체 - 자연 및 병리학적 장벽 및 이를 극복하기 위한 전략Review Published on 2022-05-012022-09-12 Journal: Pharmacology & therapeutics [Category] COVID19(2023년), SARS, 진단, [키워드] administration antibodies antibody Antigen approved Biological Biological barriers cellular Efficacy expected Extracellular IMPROVE intravenously less overcome pandemic pathological Pathological barriers Patient SARS-CoV2 systemic side effect therapeutic Therapeutic antibody Therapeutic strategies therapy Treatment [DOI] 10.1016/j.pharmthera.2021.108022 PMC 바로가기 [Article Type] Review
Mechanisms of immunothrombosis and vasculopathy in antiphospholipid syndrome항인지질 증후군에서 면역혈전증과 혈관병증의 기전Review Published on 2022-05-012022-09-12 Journal: Seminars in immunopathology [Category] MERS, 진단, [키워드] activated antibody antiphospholipid antibody Antiphospholipid syndrome Autoimmune cell proliferation cells characterized circulating Coagulation Coagulopathy complement complications COVID-19 develop disease driver endothelial cells event expand Extracellular Factor fibrinolytic highlight immunothrombosis infiltration marker NETs Neutrophil extracellular trap Neutrophil extracellular traps occlusive organ damage pathogenic pathophysiology Patient phospholipid Platelets Protein recognize similarity syndrome thrombosis vascular thrombosis Vasculopathy [DOI] 10.1007/s00281-022-00916-w PMC 바로가기 [Article Type] Review
Ultrastructural examination of lung “cryobiopsies” from a series of fatal COVID-19 cases hardly revealed infected cells일련의 치명적인 COVID-19 사례에서 폐 "냉동생검"의 미세구조 검사는 감염된 세포를 거의 드러내지 않음Article Published on 2022-05-012022-09-11 Journal: Virchows Archiv [Category] COVID19(2023년), SARS, 치료기술, [키워드] accumulation aggregates alveolar alveolar damage alveolar epithelium Analysis Autopsy caused Cell cell types cells coronavirus COVID-19 patient COVID-19 patients death Detachment diffuse Diffuse alveolar damage electron electron microscopy Endothelium erythrocytes Extracellular fatal COVID-19 FIBRIN fixation fixed granulocyte Histopathology hyaline membrane hyaline membranes hyperplasia immune impairment IMPROVE infected cell investigated latency leukocyte leukocytes lung lung damage macrophages mechanisms Microscopy neutrophilic Particle Patient Region Replication respiratory distress Respiratory distress syndrome Sample SARS‐CoV‐2 Stage Stress stress response the disease the patient these cell These cells Thin section thrombocyte Thrombocytes tissue Ultrastructural analysis ventilated patient ventilated patients virus Virus particle. [DOI] 10.1007/s00428-022-03308-5 PMC 바로가기 [Article Type] Article
Low phase angle is associated with 60-day mortality in critically ill patients with COVID-19낮은 위상각은 COVID-19 중환자의 60일 사망률과 관련이 있습니다.Article Published on 2022-05-012022-09-11 Journal: JPEN. Journal of parenteral and enteral nutrition [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus Admission Analysis association bioelectrical impedance Bioelectrical Impedance Analysis biological marker body composition body water clinical outcomes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critically ill Critically ill patient critically ill patients Cutoff death Extracellular female hazard ratio Hospital stay increased risk intensive care intensive care unit admission Kaplan-Meier curves Linear regression model male Malnutrition mechanical ventilation mechanically ventilated patient mechanically ventilated patients Mortality mortality risk nutrition risk nutrition status Odds ratio on mechanical ventilation parameter Pathologies Patient Phase angle predictor prospective cohort risk Risk assessment SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly increased survival analysis variable was performed water were used with COVID-19 [DOI] 10.1002/jpen.2236 PMC 바로가기 [Article Type] Article