Implementation of the ERAS (Enhanced Recovery After Surgery) protocol for colorectal cancer surgery in the Piemonte Region with an Audit and Feedback approach: study protocol for a stepped wedge cluster randomised trial: a study of the EASY-NET project감사 및 피드백 접근 방식을 사용하여 Piemonte 지역에서 대장암 수술을 위한 ERAS(수술 후 회복 강화) 프로토콜 구현: 계단형 쐐기형 클러스터 무작위 시험을 위한 연구 프로토콜: EASY-NET 프로젝트 연구Article Published on 2021-06-032022-09-11 Journal: BMJ Open [Category] SARS, 임상, 치료기술, [키워드] Activation adopted application approach approved assigned Audit Care changes in clinically Cluster Colorectal cancer Colorectal surgery Committee complications Control of pain COVID-19 COVID-19 pandemic detect endpoints enhanced ERAS ethical committee Ethics expected feedback four groups Health Health care hospital Hospital stay incidence include Italy LOS management multicentre outcome Pain pathway Patient peer-reviewed postoperative Postoperative Complications Primary outcome promote protocol quality in health care randomised Randomised trial Randomly randomly divided reduce reduction Region registration number Sample size Satisfaction secondary Secondary outcomes Statistical power stratified Stress Study protocol surgery surgical Surgical stress Volume [DOI] 10.1136/bmjopen-2020-047491 PMC 바로가기 [Article Type] Article
Decreased Low-Density Lipoprotein Cholesterol Level Indicates Poor Prognosis of Severe and Critical COVID-19 Patients: A Retrospective, Single-Center StudyMedicine Published on 2021-05-262022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Acute cardiac injury Admission Analysis cardiac injury Characteristics Comorbidity Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients critical COVID-19 patient critical COVID-19 patients Critically ill patient CRP level death Decreased dysfunction dyslipidemia enrolled four group four groups global public health group Hospitalization ICU immune increased risk Inflammation Injury intensive care LDL-C Level lipoprotein liver dysfunction Low-density lipoprotein Low-Density Lipoprotein cholesterol Lymphocyte count mechanical ventilation Mortality not differ Patient Pearson correlation Poor poor prognosis positively correlated Prognosis proportion reduction renal dysfunction severe and critical COVID-19 patients severe patients Shock shown Symptom treated [DOI] 10.3389/fmed.2021.585851 PMC 바로가기 [Article Type] Medicine
A clinical staging proposal of the disease course over time in non-severe patients with coronavirus disease 2019Article Published on 2021-05-212022-10-04 Journal: Scientific Reports [Category] SARS, 임상, [키워드] accompanied cardiac damage change characterized Clinical practice Clinical sign Coagulopathy convalescent phase coronavirus disease Course COVID-19 defined Diseases elevated four groups hematological hospital Host immunology Inflammatory marker inflammatory markers Inflammatory response Interaction lymphopenia majority non-severe patient occurred other organ Pathogenesis Patient Perspective Pneumonia Retrospective study Stage symptoms onset the disease therapy virus with COVID-19 [DOI] 10.1038/s41598-021-90111-y PMC 바로가기 [Article Type] Article
Vitamin D deficiency is associated with COVID-19 positivity and severity of the disease비타민 D 결핍은 COVID-19 양성 및 질병의 중증도와 관련이 있습니다Article Published on 2021-05-012022-09-11 Journal: Journal of medical virology [Category] MERS, SARS, 바이오마커, [키워드] (average age addition affected age age and gender average average age C-reactive protein C-reactive protein (CRP Chain Reaction Clinical outcome clinical outcomes Computed tomography coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient CRP CRP level CRP levels D-dimer decrease deficiency distribution evaluated examined four group four groups group hospital Hospital stay intensity investigated Laboratory test lung medical record medical records no difference Non-COVID-19 non-COVID-19 patient Non-COVID-19 patients Patient patients PCR PCR positivity PCR test PCR testing polymerase chain polymerase chain reaction radiological finding retrospective cohort study severity significantly lower tested the disease Vitamin D vitamin D deficiency vitamin D level vitamin D levels with COVID-19 women [DOI] 10.1002/jmv.26832 PMC 바로가기 [Article Type] Article
Spectrum and Clinical Characteristics of Symptomatic and Asymptomatic Coronavirus Disease 2019 (COVID-19) With and Without PneumoniaMedicine Published on 2021-04-012022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome applied Asymptomatic Asymptomatic COVID-19 caused Characteristics China clinical Clinical characteristics coronavirus Coronavirus disease 2019 COVID-19 COVID-19 case COVID-19 group COVID-19 patient Covid-19 subgroup database defined evaluated extracorporeal membrane oxygenation four groups global pandemic groups hospital Hospitalization Hospitalized in viral information Invasive mechanical ventilation Laboratory mechanical ventilation medical resource no difference Non-invasive oropharyngeal swab Pneumonia Prognosis radiologic renal replacement therapy Spectrum stratified Symptom symptomatic symptomatic and asymptomatic Symptoms Viral load viral shedding [DOI] 10.3389/fmed.2021.645651 PMC 바로가기 [Article Type] Medicine
Repurposing of some anti-infective drugs for COVID-19 treatment: A surveillance study supported by an in silico investigationCOVID-19 치료를 위한 일부 항감염제의 용도 변경: in silico 조사에 의해 뒷받침되는 감시 연구Article Published on 2021-04-012022-09-11 Journal: International journal of clinical practice [Category] SARS, 신약개발, 치료기술, 치료제, [키워드] AAK1 added Admission ADP-ribose anti-infective drug antimicrobial Antimicrobials applied Azithromycin binding binding free energy binding mode binding modes Clinical finding Clinical findings clinical outcomes Combination Compound computational studies Computational study COVID-19 death detect diarrhoea docked docking experiment docking experiments docking score doxycycline drug effective Efficacy enrolled explain females four groups free energy Free energy calculations group IMPROVE in silico in vitro inhibitors intensive care kinase lead MDs Mild mild to moderate moderate Moderate COVID-19 moderate symptoms molecular molecular dynamic simulations nitazoxanide not seen outcomes phosphatase Protein target replacement reported repurposing required Reverse transcription-polymerase chain reaction ribose starting point subject subjects supported Surveillance Symptom symptomatic improvement therapeutic potential treated treating COVID-19 Treatment turn Viral [DOI] 10.1111/ijcp.13877 PMC 바로가기 [Article Type] Article
The concept of disease in the time of COVID-19COVID-19 시대의 질병 개념Article Published on 2021-02-162022-09-01 Journal: Theoretical Medicine and Bioethics [Category] MERS, 진단, [키워드] Asymptomatic component Concept of disease condition coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 outbreak diagnostic diagnostic test disease Emergency extension four group four groups groups Harm implication Infection measure pandemic Philosopher positive problem problems risk sick Sick role Sickness state of emergency suggestion the disease [DOI] 10.1007/s11017-021-09540-5 PMC 바로가기 [Article Type] Article
A quadruple blinded placebo controlled randomised trial to evaluate the effectiveness of an Iodine complex for patients with mild to moderate COVID-19 in Pakistan (I-COVID-PK): A structured summary of a study protocol for a randomised controlled trial파키스탄에서 경증에서 중등도의 COVID-19 환자에 대한 요오드 복합체의 효과를 평가하기 위한 4중 맹검 위약 대조 무작위 시험(I-COVID-PK): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-02-102022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] 30-Day mortality Admission age alleviation alleviation of symptom approved Arm ARMS baseline blinded Blinding calculated Care care providers Chest chest scan Chronic illness clinic clinical Clinical improvement Clinical management co-morbidities co-morbidity comparator complex coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 adult patient COVID-19 adult patients Disinfection dissemination doctor Effectiveness Efficacy element enrolled evaluate excluded four group four groups Gender groups HRCT Infection information initial initial symptom initial symptoms Intention investigator investigators Iodine IRB lung involvement management guidelines Mild mild to moderate mild to moderate disease Moderate COVID-19 moderate disease morbidities National Health Service National Health Services non-pregnant females number objective outcome Pakistan participant Participants Patient patients PCR Placebo placebo-controlled Polymer positive Primary outcomes protocol radiological radiological improvement randomised randomised controlled trial Randomised trial randomization Randomized receiving recruited recruitment Registered remained reported resolved RT-PCR Sample size SARS-CoV-2 RT-PCR secondary outcome severity severity of symptom shown Standard standard care status Study protocol supplementary material Symptom symptomatic syrup the patient time Trial Version Viral viral clearance website [DOI] 10.1186/s13063-021-05081-3 PMC 바로가기 [Article Type] Letter
Clinical evaluation of commercial automated SARS-CoV-2 immunoassays상용 자동화된 SARS-CoV-2 면역분석의 임상 평가Article Published on 2021-02-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료기술, [키워드] antibody Antibody detection assays automated Automated SARS-CoV-2 antibody detection clinical Control COVID-19 infection diagnostic diagnostic sensitivities Diagnostic specificities diagnostic specificity DiaSorin epitope Euroimmun excluded facilitate four groups High throughpu testing IgA IgG IgM IgM/IgG immunoassay Infection involved laboratory-confirmed lack lead Longitudional monitoring of antibody development negative control negative controls number of samples Numerous pandemic control Patient performed positive qRT-PCR released reproducibility retrospective Roche SARS-CoV-2 SARS-CoV-2 antibody sensitivity sera Seroconversion serological serological assays serological result Serpprevalence. significantly SNIBE specificity the disease validation [DOI] 10.1016/j.ijid.2020.12.003 PMC 바로가기 [Article Type] Article
Evidence-based of conjunctival COVID-19 positivity: An Italian experience: Gemelli Against COVID Group결막 COVID-19 양성의 증거 기반: 이탈리아 경험: COVID-19에 반대하는 GemelliOriginal Research Articles Published on 2020-12-232022-09-11 Journal: European Journal of Ophthalmology [Category] MERS, SARS, 치료기술, [키워드] Against blood chemistry C-reactive protein C-RP Care Chest radiography clinical parameter clinical trials Computed tomography Conjunctiva conjunctival Conjunctival swab conjunctival swabs conjunctivitis coronavirus COVID COVID-19 D-dimer Dyspnea enrolled Eye infection ferritin fibrinogen FIVE four groups group highest Hospitalized impairment Infection Italian Lactate lactate dehydrogenase LDH lowest Nasopharyngeal swab NPs ophthalmologists outcome oxygen oxygen saturation Patient patients hospitalized patients with SARS-CoV-2 Personalized medicine positive precautionary measures pulmonary pulmonary impairment radiologic respiratory Respiratory Coronavirus SARS-CoV-2 SARS-COV-2 infection secondary outcome Secondary outcomes severe acute respiratory coronavirus severe pulmonary impairment significantly statistically Swab swabs tears Transmission Trial registration virus [DOI] 10.1177/1120672120976548 PMC 바로가기 [Article Type] Original Research Articles