Mutations in the B.1.1.7 SARS-CoV-2 Spike Protein Reduce Receptor-Binding Affinity and Induce a Flexible Link to the Fusion PeptideArticle Published on 2021-05-082022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] A570D ACE2 ACE2 binding Affect affected affinity Analysis B.1.1.7 B.1.1.7 variant binding affinity biochemical Cell consequence Contact COVID-19 D614G D614G mutation fusion fusion peptide Interaction interface region linear molecular Molecular dynamics simulation Mutation N501Y N501Y mutation Patient RBD Receptor binding reduced Salt Bridge SARS-CoV-2 significantly spike Spike protein stability starting point structural flexibility The B.1.1.7 the RBD the receptor-binding domain the SARS-CoV-2 the SARS-CoV-2 virus the spike protein trimer variant virus wild type [DOI] 10.3390/biomedicines9050525 PMC 바로가기 [Article Type] Article
Killed whole-genome reduced-bacteria surface-expressed coronavirus fusion peptide vaccines protect against disease in a porcine model죽은 전체 게놈 감소 박테리아 표면 발현 코로나 바이러스 융합 펩티드 백신은 돼지 모델에서 질병으로부터 보호합니다423 Published on 2021-05-042022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 진단, [키워드] Amino acid amino acid residues anamnestic response Bacteria Bacterial Betacoronavirus Cell cell surface clinical disease conserved core coronavirus coronavirus disease Coronavirus disease 2019 coronavirus vaccine COVID-19 cross-protection demonstrated diarrhea disease downstream Efficacy elicited ENhance epidemic diarrhea Escherichia coli evaluated Express expressing expression vector fusion peptide genome-reduced bacteria vaccine platform highly conserved fusion peptide immune system Immunity Interaction interferon interferon-γ offer pandemic Pathogens PEDV peptide PIGS platform porcine epidemic diarrhea virus (PEDV) principle proof PROTECT Protective provide provided reduced residue responses SARS-CoV-2 sequence Significance sterilizing immunity target tested tissue Transport upstream utility Vaccine vaccine antigen vaccine immunogenicity vaccine platform Vaccines viral RNA load virus whole-genome [DOI] 10.1073/pnas.2025622118 PMC 바로가기 [Article Type] 423
Mutations in membrane-fusion subunit of spike glycoprotein play crucial role in the recent outbreak of COVID-19스파이크 당단백질의 막 융합 소단위의 돌연변이는 최근 COVID-19 발병에서 중요한 역할을 합니다Article Published on 2021-05-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acids Analysis caused Comparative analysis coronavirus coronavirus disease coronavirus disease-2019 COVID-19 envelope Epidemic facilitate Features furin fusion peptide help Host hydrophobic intrinsically intrinsically disordered region membrane molecular molecular recognition feature nucleoprotein outbreak pandemic pathogenicity peptide performed polar preventive measure preventive measures proteolysis provide reason reported residue SARS-coronavirus SARS-CoV SARS-CoV-2 SARS-CoV2 severe acute respiratory syndrome Coronavirus spike glycoprotein spike glycoproteins structural protein structural proteins Substitution subunit Surveillance Transmissibility transmissibility of SARS-CoV-2 viruses [DOI] 10.1002/jmv.26598 PMC 바로가기 [Article Type] Article
Linear epitope landscape of the SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients1,051명의 COVID-19 환자로부터 구성된 SARS-CoV-2 스파이크 단백질의 선형 에피토프 풍경Article Published on 2021-03-302022-09-12 Journal: Cell Reports [Category] SARS, 진단, [키워드] a peptide microarray acute respiratory syndrome antibodies C-terminal domain cleavage site Clinical outcome coronavirus coronavirus disease COVID-19 COVID-19 patient CTD disease severity epitope facilitate fusion peptide generate Humoral response IgG immunogenic Immunoglobulin lack linear linear epitope landscape linear epitopes mice Neutralizing activity Neutralizing antibodies Patient peptide Protein RBD Receptor binding domain Region SARS-CoV-2 serum severity spike Spike protein the SARS-CoV-2 the Spike Vaccine virus [DOI] 10.1016/j.celrep.2021.108915 PMC 바로가기 [Article Type] Article
Longitudinal antibody repertoire in “mild” versus “severe” COVID-19 patients reveals immune markers associated with disease severity and resolutionComparative Study Published on 2021-03-052022-10-04 Journal: Science Advances [Category] SARS, 바이오마커, 진단, [키워드] acute COVID-19 Affinity maturation antibody affinity Antibody binding antibody marker antibody repertoire antigenic clinical disease coronavirus disease COVID-19 COVID-19 patient COVID-19 patients demonstrated disease severity effective epitope Evolution of SARS-CoV-2 faster fusion peptide IgA IgG immune marker immunodominant Immunoglobulin increase in knowledge Limited longitudinal maturation Mild Patient patients with COVID-19 prefusion RBD Receptor binding domain reveal SARS-COV-2 infection SARS-CoV-2 spike sequence severe COVID-19 [DOI] 10.1126/sciadv.abf2467 PMC 바로가기 [Article Type] Comparative Study
Distinct antibody repertoires against endemic human coronaviruses in children and adultsResearch Article Published on 2021-02-222022-10-30 Journal: JCI Insight [Category] COVID-19, MERS, [키워드] Acidic Acute respiratory infection antibody antibody repertoire Antibody Response B cell epitopes B cell response children Cohort comprehensive analysis conserved Coronavirus infection Coronaviruses cross-reactive dominant donors endemic HCoV endemic human coronavirus Epidemic fusion peptide HCoV-HKU1 human antibody response humans IgG immunoglobulins immunology immunoprecipitation Infectious disease linear monoclonal antibody N-terminal nucleocapsid peptide polyprotein predominant Prophylactic Proteins ranged Region S2′ cleavage Sequencing Seroprevalence specificity the spike protein therapeutic Vaccine design virus [DOI] 10.1172/jci.insight.144499 PMC 바로가기 [Article Type] Research Article
Antibody affinity maturation and plasma IgA associate with clinical outcome in hospitalized COVID-19 patients입원한 COVID-19 환자의 임상 결과와 관련된 항체 친화도 성숙 및 혈장 IgAArticle Published on 2021-02-222022-09-12 Journal: Nature Communications [Category] MERS, 바이오마커, 진단, 치료기술, [키워드] Affinity maturation Analysis antibodies antibody antibody affinity Antibody binding antibody kinetics association binding antibodies clinical disease Clinical outcome Clinical severity Clinical symptoms COVID-19 COVID-19 disease COVID-19 patient Critical cytokine disease epitope Exacerbation fusion peptide hACE2 high plasma level high plasma levels hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients ICU patient ICU Patients IgA IgA level IL-6 IL-8 immune parameter immune response immune responses immunopathology lead maturation MCP-1 neutralization titers non-ICU outcome patients with COVID-19 peptide plasma plasma sample prefusion receptor binding motif SARS-CoV-2 SARS-CoV2 infection scrutiny severity Spike protein Survivors sustained the SARS-CoV-2 TNFα Viral host response viral infection [DOI] 10.1038/s41467-021-21463-2 PMC 바로가기 [Article Type] Article
Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusionSARS-CoV-2 스파이크의 푸린 절단은 감염 및 세포-세포 융합을 촉진하지만 필수적이지는 않습니다Research Article Published on 2021-01-252022-08-13 Journal: PLoS Pathogens [Category] COVID-19, Medicine and Health Sciences, [키워드] ACE2 ACE2 receptor activate activated acute respiratory syndrome coronavirus Amino acid Antiviral antiviral therapies attachment binding Cell cell-cell fusion cells cellular protease cellular proteases cleavage cleaved cocktail coronavirus COVID-19 pandemic CRISPR CRISPR-Cas9 Donor drug focus furin furin cleavage furin inhibitor furin inhibitors furin knockout cell furin knockout cells furin protease fusion fusion peptide host cell host cell membrane host cell receptor infect infected cell Infection inhibitor inhibitors motif multibasic site multinucleated cells mutant Mutation peptide pre-activation Prevent promote protease protease TMPRSS2 Protein reduce reduces required Research respiratory responsible reveal S protein S-mediated cell-cell fusion SARS-CoV-2 SARS-CoV-2 antiviral therapy SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spread syncytia formation target cell the S protein the SARS-CoV-2 thought TMPRSS2 TMPRSS2 protease treat triggered triggering unique Viral viral infection Viral protein viral spread virus virus entry virus entry process virus-host membrane fusion [DOI] 10.1371/journal.ppat.1009246 PMC 바로가기 [Article Type] Research Article
Repositioning of Ligands That Target the Spike Glycoprotein as Potential Drugs for SARS-CoV-2 in an In Silico StudyArticle Published on 2020-11-292022-10-30 Journal: Molecules [Category] COVID-19, [키워드] absence Amino acid bind binding candesartan cell membrane conformational changes COVID-19 Docking studies drug drugs FDA FDA-approved drugs food fusion peptide glycoprotein health emergency identify inhibit losartan molecular docking pandemic pharmacological agent Potential Prevent RBM receptor receptor binding motif repositioning Ritonavir SARS-CoV-2 specific treatment spike glycoprotein steroid target the SARS-CoV-2 the Spike this new coronavirus Treatment viral entry viral membrane virus replication [DOI] 10.3390/molecules25235615 PMC 바로가기 [Article Type] Article
Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal포르투갈에서 SARS-CoV-2 Spike Y839 변종의 대규모 보급Research Article Published on 2020-11-252022-09-10 Journal: Emerging Microbes & Infections [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] anti-viral drug Anti-viral drugs collaboration confirmed case contributing to country COVID-19 COVID-19 case D839Y dissemination Effect Epidemic Epidemics experimental validation exponential phase Frequency functional fusion peptide Genetic variant Genome genomes Genomic epidemiology Genomic surveillance Italy massive motif Mutation peptide Portugal prevalent Region relative frequency required SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant selective Sequencing spike spike variants Spread Support Surveillance the epidemic the Spike variant variants [DOI] 10.1080/22221751.2020.1844552 PMC 바로가기 [Article Type] Research Article