Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary FunctionSNP 및 SNP-by-Smoking 상호 작용의 게놈 전체 공동 메타 분석은 폐 기능에 대한 새로운 유전자좌를 식별합니다Research Article Published on 2012-12-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect analysis applied association Author Autoimmune cigarette smoking compared complex conducted demonstrated differential expression DNER DQB1 Effect Effects European evaluated Evidence evidence of expiratory expressed FEV forced expiratory volume forced vital capacity found function Gene gene region Genetic genetic loci genetic risk factor Genome-wide association studies Genome-wide association study highlight HLA region HLA-DQA2 HLA-DQB1 Human airway epithelium human lung tissue identify implicated Interaction involved joint KCNJ2 loci lung Lung disease measure Meta-analysis meta-analysis meta-analysis model novel nucleotide Phenotypes polymorphism progression pulmonary Pulmonary function Region regions related shown single nucleotide Single nucleotide polymorphism smoker Smokers smoking SNP SNPs SOX9 study participant trait utility vital capacity Volume [DOI] 10.1371/journal.pgen.1003098 PMC 바로가기 [Article Type] Research Article
Reduced Lentivirus Susceptibility in Sheep with TMEM154 MutationsTMEM154 돌연변이가 있는 양의 렌티바이러스 감수성 감소Research Article Published on 2012-01-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95% CI Affect affecting age allele Analysis analyzed Author biological function Case-control cause caused coding region Cohort disease domain E35 exceeded expressed Extracellular FIVE form forms frameshift full-length genetic risk factor genetic risk factors Genetic variation Genome-wide association study genome-wide significance Genotype Glutamate greater Haplotype haplotypes help homozygous host immune system identify incurable Infected infected case infected cases Infection isoform lentivirus lysine mechanism Missense multi multiple tissues mutant mutant virus Mutation nine odds of infection Older P -value peptide Pneumonia position predicted primates PROTECT Protein Reinfection Relative risk remained repeated respiratory Retroviral infection risk of infection Sanger sequencing sheep signal peptide single SNP susceptible target The United States TMEM154 transmembrane protein uninfected uninfected control United States Variation were used with infection [DOI] 10.1371/journal.pgen.1002467 PMC 바로가기 [Article Type] Research Article
Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence주요 대립 유전자 참조 서열을 사용한 가족 4중주에서의 단계적 전체 게놈 유전적 위험Research Article Published on 2011-09-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy allele Analysis approach Author base pairs base pairs) Blood blood clot characterization coding compound heterozygosity contribute contributing to demonstrated develop disease disease risk disease-associated estimation facilitate family Gene genetic determinant genetic determinants genetic information genetic profile genetic risk genetic risk factor genetic risk factors Genetic variation Genome genomes Genotype Haplotype Human human leukocyte antigen identify Interpretation leukocyte loci lowest lung Major median medications methodology nuclear nuclear family occur pharmacological predisposition Pulmonary embolism quantification Quartet Recombination reference reference sequence risk Risk assessment risk for disease sequence Sequencing sequencing error sequencing errors therapy Thrombophilia variant whole-genome sequencing [DOI] 10.1371/journal.pgen.1002280 PMC 바로가기 [Article Type] Research Article