Comparative genomic analysis of the human genome and six bat genomes using unsupervised machine learning: Mb-level CpG and TFBS islands비지도 머신 러닝을 사용한 인간 게놈과 6개의 박쥐 게놈 비교 게놈 분석: Mb 수준 CpG 및 TFBS 섬Comparative Study Published on 2022-07-082022-09-11 Journal: BMC Genomics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 3D structure 3D Structures addition Algorithm Analysis artificial artificial intelligence bat bats binding Centromeric heterochromatin characteristic Characteristics chromosomes class Clustering Comparative conducted contributing to CpG diagnostic dinucleotide disease-causing distribution Ebola Emerging infectious disease feature Features function Gene Expression Genome genomes genomic Genomic analysis help hosts Human Human genome humans Infectious disease information Interaction involved knowledge machine machine learning motif natural reservoir nuclear oligonucleotide Oligonucleotide composition oligonucleotides Protein Region regions Regulation reveal RNA viruses SARS-CoV-2 self-organization Self-organizing map Self-organizing map. sequence TFS the SARS-CoV-2 thought transcription factor transcription factors variety virus viruses zoonotic [DOI] 10.1186/s12864-022-08664-9 PMC 바로가기 [Article Type] Comparative Study
Mutational cascade of SARS-CoV-2 leading to evolution and emergence of omicron variant오미크론 변이체의 진화와 출현으로 이어지는 SARS-CoV-2의 돌연변이 캐스케이드Article Published on 2022-07-022022-09-11 Journal: Virus research [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] Alpha Analysis cascade COVID-19 D614G Delta emergence events Evolution followed by Genome genomes GISAID H655Y Lambda majority Mutation mutations non-structural protein Non-synonymous Non-synonymous mutation NSP, non-structural protein nucleocapsid protein omicron Omicron variant ORF6 P681H performed Phylogeny RdRP rdrp, RNA dependent RNA polymerase. Repository RNA RNA dependent RNA polymerase RNA polymerase SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2, COVID-19, genome-wide, evolution, variants, VOC, VOI, VUM, SNP, mutation, non-synonymous, silent mutation, spike, RNA dependent RNA polymerase, NSP, UTR: Abbreviations: VOC, variant of co silent SNP specific clade Transmissibility untranslated region UTR UTR, untranslated region variant variant of SARS-CoV-2 variants variants of concern VoC VOI, variant of interest VUM, variant under monitoring while whole genome [DOI] 10.1016/j.virusres.2022.198765 PMC 바로가기 [Article Type] Article
Whole-genome sequencing reveals host factors underlying critical COVID-19전체 게놈 시퀀싱은 중요한 COVID-19의 기저에 있는 숙주 요인을 밝힙니다Article Published on 2022-07-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, 치료기술, 치료제, [키워드] Adhesion Molecule Antigen association associations ATP11A BCL11A caused CD209 Coagulation coagulation factor Colocalization Control COVID-19 Critical Critical care Critical disease Critical illness Critically ill disease disease severity Evidence expression Factor failure FUT2 Gene Expression Genetic variation genetics Genome genomes GenOMICC Hospitalization Host ICAM5 identify IL10RB Immune-mediated increased expression independent individual infection with SARS-CoV-2 inflammatory lung injury influence interferon intravascular coagulation involved leucocyte life-threatening Lung injury mechanism mechanisms membrane mendelian randomization MUC1 mucin myeloid cell pathophysiology PLSCR1 provide pulmonary inflammation reduced replicate reveal SELE Sequencing significantly Support targets transcriptome-wide underlying disease variant variants Viral viral replication whole-genome sequencing [DOI] 10.1038/s41586-022-04576-6 PMC 바로가기 [Article Type] Article
Chinese Medicine Meets Conventional Medicine in Targeting COVID-19 Pathophysiology, Complications and Comorbidities한의학, COVID-19 병태생리학, 합병증 및 동반질환을 표적으로 하는 기존 의학과의 만남Comparative Study Published on 2022-07-012022-09-11 Journal: Chinese journal of integrative medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] activity approved China Chinese Chinese medicine clinical trial clinically Comorbidities Comorbidity Complication Conventional coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 complication COVID-19 complications diabetes drug DrugBank DrugBank database genomes headache hypertension ingredient investigated Kyoto mechanism Medicine Medicines modulate modulated modulation National Health Commission natural NHCC obesity Pain pathophysiology Pathways product searched Source Specy target targeting targets therapeutic therapeutic mechanism. Traditional Traditional Chinese medicine Treatment viral replication was obtained [DOI] 10.1007/s11655-022-3573-0 PMC 바로가기 [Article Type] Comparative Study
Screening the hub genes and analyzing the mechanisms in discharged COVID-19 patients retesting positive through bioinformatics analysis생물정보학 분석을 통해 퇴원한 코로나19 환자 재검사에서 허브 유전자 스크리닝 및 기전 분석Article Published on 2022-07-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] 유전자 메커니즘, [키워드] ALKBH6 AMBRA1 Analysis analyzed ANAPC1 Apoptosis ATP1A1 ATP1A1-AS1 bioinformatics Bioinformatics analysis convalescent COVID-19 COVID-19 patient COVID-19 patients cytoHubba differentially expressed gene discharge discharged DISP1 DOCK4 down-regulated down-regulated gene enrichment analysis expression data FAM149B1 FAM241B Gene Expression Omnibus Gene ontology Genes genomes GEO healthy control hub genes IGLV1-40 immune immune response KEGG Kyoto LRRC69 management mechanism MICAL3 Microarray MIR1249 mRNA Pathogenesis Patient patients PLPPR2 positive PPI PPI network Prognosis prognostic protein-protein interaction PSMG1 R software Rab11b RAB11B-AS1 retesting positive after discharged. Ribonucleic acid risk screened Screening selected significant enrichment SNRPD1 SNRPD2 SORT1 TP53BP1 TRAV18 two group two groups up-regulated virus was performed [DOI] 10.1002/jcla.24495 PMC 바로가기 [Article Type] Article
First cases of infection with the 21L/BA.2 Omicron variant in Marseille, France프랑스 마르세유에서 21L/BA.2 오미크론 변종 첫 감염 사례Article Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid amino acid substitution amino acid substitutions Clinical outcome Cluster country deletions Denmark deviation diagnosed distribution emergence England facilitate flattening France Genome genomes incidence Infection initial Interaction Marseille MONITOR N-terminal domain Nepal Next-generation sequencing nucleotide nucleotide substitution nucleotide substitutions omicron Omicron variant Phylogeny predominant qPCR remained resulting SARS-CoV-2 Singapore South Africa southern France Spike protein Surveillance the spike protein Travel variant viral genome viral genomes [DOI] 10.1002/jmv.27695 PMC 바로가기 [Article Type] Article
Insertion-and-Deletion Mutations between the Genomes of SARS-CoV, SARS-CoV-2, and Bat Coronavirus RaTG13SARS-CoV, SARS-CoV-2 및 박쥐 코로나바이러스 RaTG13의 게놈 간의 삽입 및 삭제 돌연변이Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 base bases bat bat coronavirus RaTG13 Complete coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) developmental distribution FIVE Frame gene sequence Genome genome sequence Genome sequences genomes Inconclusive INDEL indels insertion insertion-and-deletion mutation mechanism MOST Mutation mutation rate mutations Noncoding region nonstructural protein 3 Open reading frame ORF ORF8 ORF8 gene ORF8 genes Point mutation point mutations protein 3 RaTG13 replaced REPLACED BY replacement S1 domain SARS-CoV SARS-CoV-2 SARS-CoV-2 genome sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus (SARS-CoV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein the SARS-CoV-2 genome the spike protein viral genome virus [DOI] 10.1128/spectrum.00716-22 PMC 바로가기 [Article Type] Article
Contrasting Epidemiology and Population Genetics of COVID-19 Infections Defined by Multilocus Genotypes in SARS-CoV-2 Genomes Sampled Globally전 세계적으로 샘플링된 SARS-CoV-2 게놈의 다중 유전자형에 의해 정의된 COVID-19 감염의 대조 역학 및 인구 유전학Article Published on 2022-06-292022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료법, [키워드] aligned allele frequency alleles Alpha Amino acid amino acids Analysis Asia association Beta caused Cluster Clustering codon component continent continuous surveillance COVID-19 COVID-19 case COVID-19 incidence COVID-19 vaccine COVID-19 vaccines criteria deaths delta variant demographic data demographics demonstrated dependent on discriminant analysis distribution eight epidemiological Epidemiology Evolution Gamma Genetic genetics Genome genomes Genomic surveillance Genotype genotyping geographical regions GISAID help higher risk Inclusion inclusion criteria Intervention linkage Local loci majority matrix MONITOR multilocus Mutation mutation and transmission. North North America nucleocapsid older patient older patients ORF1ab ORF3a ORF8 persistence polymorphism Population populations predominant Prevalence reference genome repertoire Result risk of infection SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 genomic surveillance SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 reference genome selected South America spatiotemporal Spread suggested the SARS-CoV-2 These data Transmission utility variant variants variants of concern Viral transmission VoC VOCs younger patient younger patients [DOI] 10.3390/v14071434 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 intra-host recombination during superinfection with Alpha and Epsilon variants in New York City뉴욕시에서 알파 및 엡실론 변이체로 중복 감염 중 SARS-CoV-2 숙주 내 재조합 검출Article Published on 2022-06-252022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] allele Alpha Alpha variant B.1.1.7 B.1.429 classic coding regions Coronavirus replication detection Diversity Epsilon feasible full genome sequencing functions generate genetic diversity Genome genome sequence genomes Haplotype Host identify independent individual infect New York City nucleocapsid Occurrence ORF pathogen Pathogens Recombination reveal S gene SARS-CoV-2 superinfection Support variant virus [DOI] 10.1038/s41467-022-31247-x PMC 바로가기 [Article Type] Article
Screening of Gene Expression Markers for Corona Virus Disease 2019 Through Boruta_MCFS Feature SelectionBoruta_MCFS 기능 선택을 통한 코로나 바이러스 질병 2019에 대한 유전자 발현 마커 스크리닝Article Published on 2022-06-222022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 치료기술, [키워드] addition Analysis analyzed bioinformatics biological function Biomarker Biomarkers center Classifier Corona COVID-19 diagnosis of COVID-19 disease expression data Feature selection Gene Expression gene expression markers Gene ontology Genes genomes Improving Kyoto limitation network analysis outbreak pandemic Pathways positive positive sample Precision problem protein-protein interaction random Random forest random forest classifier reduction SARS-CoV-2 virus screened Screening selected Selection signaling pathway signaling pathways test results Virus Disease was performed Wuhan Wuhan, China [DOI] 10.3389/fpubh.2022.901602 PMC 바로가기 [Article Type] Article