Germinal center – Page 4 – Communicable Diseases Research

Rap1 Is Essential for B-Cell Locomotion, Germinal Center Formation and Normal B-1a Cell Population

Original Research

Published on 2021-06-012023-08-30
Journal: Frontiers in Immunology [Category] E형 간염,

[키워드] B cells B-1a chemotactic factor Germinal center Rap1
[DOI] 10.3389/fimmu.2021.624419 PMC 바로가기 [Article Type] Original Research

Dynamic modulation of spleen germinal center reactions by gut bacteria during Plasmodium infection

Article

Published on 2021-05-112024-08-28
Journal: Cell Reports [Category] 말라리아,

[키워드] Antibiotics Germinal center gut microbiota Humoral immunity Plasmodium falciparum Plasmodium yoelii severe malaria

Histomorphological patterns of regional lymph nodes in COVID-19 lungs

COVID-19 폐에서 국소 림프절의 조직 형태학적 패턴

Main Topic: COVID-19

Published on 2021-05-052022-09-10
Journal: Der Pathologe [Category] MERS, SARS, 유전자 메커니즘, 치료기술,

[키워드] Analysis analyzed Antigen presentation Autopsies Autopsy B‐cell CD11c CD163 CD68 CD8 CD8-positive T‑lymphocytes CD8-positive T‑Lymphozyten CD8A cells Characteristics class switch COVID-19 CXCL9 cytokine Cytokine release syndrome dendritic cells described edema expression Factor follicular follicular dendritic cell follicular dendritic cells Gene expression analysis Gene expression profiling Germinal center germinal centers granzyme granzyme B heterogeneity histiocytosis hypoplasia immune response Immunity Immunoglobulin immunoglobulin class Immunohistochemie immunohistochemistry immunologic response include increased expression involved Keimzentrum lung lymph Lymph node lymph nodes material mechanism Mild mild to moderate moderate moderate to severe MZB1 objective PAK1 Patient plasmablast plasmablasts plasmacytosis qRT-PCR Region regional lymph nodes Result SARS-CoV-2 N SARS-CoV‑2 SARS-CoV‑2 severe COVID-19 Stat1 Viral Viral load was performed Zytokin-Freisetzungssyndrom
[DOI] 10.1007/s00292-021-00945-6 PMC 바로가기 [Article Type] Main Topic: COVID-19

Hemagglutinin Functionalized Liposomal Vaccines Enhance Germinal Center and Follicular Helper T Cell Immunity

헤마글루티닌 기능화 리포솜 백신은 배아 중심 및 여포 도우미 T 세포 면역을 강화합니다

Article

Published on 2021-05-012022-09-12
Journal: Advanced Healthcare Materials [Category] SARS, 진단,

A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice

Clinical and Translational Article

Published on 2021-03-122022-11-01
Journal: Med (New York, N.Y.) [Category] COVID-19, MERS, SARS,

[키워드] Abstract Adaptive immune response administration Adults affected aging antibodies Antibody Response approach booster dose caused CD4 CD8 CD8⁺ T cells Cell cellular ChAdOx1 ChAdOx1 nCoV-19 changes in Clinical outcome Context COVID-19 COVID-19 vaccine COVID-19 vaccines effective effectors elicit ENhance finding follicular funding generate Germinal center Health Humoral immunity IgG and IgM immune response immune system immunogenicity induce Infection influence intramuscular limit magnitude Measures Medicine mice morbidity and mortality Older outcome performed plasma pre-clinical testing protective immunity reduced Regulatory required risk factor robust SARS-CoV-2 SARS-COV-2 infection second dose single dose single vaccination Spread stimulate supported T follicular helper cells Th1 cells vaccination Vaccine vaccine candidate virus-neutralizing antibodies worldwide pandemic
[DOI] 10.1016/j.medj.2020.12.006 PMC 바로가기 [Article Type] Clinical and Translational Article

EZH2 inhibition by tazemetostat: mechanisms of action, safety and efficacy in relapsed/refractory follicular lymphoma

Drug Evaluation

Published on 2021-03-122024-09-04
Journal: Future Oncology [Category] 대상포진,

[키워드] B cells enhancer of zest homolog 2 epigenetics Follicular lymphoma Germinal center histone methylation tazemetostat
[DOI] 10.2217/fon-2020-1244 PMC 바로가기 [Article Type] Drug Evaluation

Original Antigenic Sin: the Downside of Immunological Memory and Implications for COVID-19

Opinion/Hypothesis

Published on 2021-03-102022-10-30
Journal: mSphere [Category] COVID-19, SARS,

The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity

질병 중증도가 다른 COVID-19 환자의 이분성 및 불완전 적응 면역

Clinical Trial

Published on 2021-03-082022-08-13
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 비임상, 임상,

[키워드] 10 asymptomatic patient 10 asymptomatic patients acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity Asymptomatic asymptomatic or mild symptomatic patients asymptomatic patient asymptomatic patients B cell response B cell responses breath caused CD8 Cell Cellular immune response characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 vaccines CXCL13 disease severity effective follicular GC response indicator GC response indicators Germinal center humoral Humoral immunity immune responses Immunity induce mechanism memory B memory B cell Mild moderate moderate or severe disease mounted Patient patients PROTECT protective immunity respiratory response robust SARS-CoV-2 SARS-CoV-2 antibody responses SARS-CoV-2-specific B-cell serum CXCL13 severe acute respiratory syndrome Coronavirus severe disease symptomatic patient T cell T cell responses T cells T-cell Response T-cell responses
[DOI] 10.1038/s41392-021-00525-3 PMC 바로가기 [Article Type] Clinical Trial

Maturation and persistence of the anti-SARS-CoV-2 memory B cell response

Article

Published on 2021-03-042023-06-20
Journal: Cell [Category] Fulltext, MERS,

[키워드] COVID-19 extrafollicular response Germinal center HKU1 Neutralizing antibodies OC43 Plasma cells RBD Somatic hypermutation Spike protein
[DOI] 10.1016/j.cell.2021.01.050 PMC 바로가기

Reaktionsmuster der lokoregionären Lymphknoten im Abflussgebiet von COVID-19-Lungen

Reaktionsmuster der lokoregionären Lymphknoten im Abflussgebiet von COVID-19-Lungen

Review

Published on 2021-02-112022-09-10
Journal: Der Pathologe [Category] MERS, SARS, 유전자 메커니즘, 치료기술,