Safety and efficacy assessment of allogeneic human dental pulp stem cells to treat patients with severe COVID-19: structured summary of a study protocol for a randomized controlled trial (Phase I / II)
중증 COVID-19 환자를 치료하기 위한 동종 인간 치수 줄기세포의 안전성 및 효능 평가: 무작위 대조 시험(I/II상)을 위한 연구 프로토콜의 구조화된 요약
Letter
[키워드] 1:1
Acidic
Adenovirus
Admission
AIDS
Alanine
alanine aminotransferase
albumin
alkaline phosphatase
Allogeneic
allogeneic human dental pulp stem cells
amyloid
Analysis
anion gap
Arm ratio
aspartate
Aspartate aminotransferase
average
B lymphocyte
basophils
Before menopause
Bilirubin
blind
blinded
Block randomization method
Blood
blood cell
Blood cells
blood pressure
Blood routine
C-reactive protein
calcium
carbon dioxide
Care
CAST
caused
Cell
cell suspension
change
chest X-ray
Child Pugh score
chlorine
cholesterol
cholinesterase
CLARITY
clinical
Clinical improvement
clinical trial
coded
Coefficient of variation
color
commenced
comparator
computer
Concentration
Consent
consent form
Continuous renal replacement therapy
control group
control groups
COVID-19
COVID-19; randomised controlled trial; protocol; human dental pulp stem cells; dental stem cell banking
COVID-2019
creatine
creatine kinase
creatinine
criteria
crystal
Cytokines
cytomegalovirus
cytomegalovirus CMV-IgG
cytomegalovirus CMV-IgM
Definition
dental pulp
dental pulp stem cells
description
detect
Diastolic blood pressure
direct bilirubin
discharge
disease
dissemination
distress
distribution
DPSCs
ECMO
Efficacy
element
enrolled
eosinophil
eosinophils
epithelial cells
estimated glomerular filtration rate
Estrogen
examined
excluded
exclusion criteria
experimental group
fat globules
Female patients
female subject
filtration rate
Final
flow cytometry
follow-up period
fungi
fungus
Globulin
glomerular filtration rate
Glucose
GRADE
Grade 1
grade 3
Grade 5
granulocyte
HBcAb
HBeAb
HBeAg
HBsAb
HBsAg
hDPSCs
Health Organization
heart rate
hematocrit
Hemodialysis
hemoglobin
hepatitis B
hepatitis C
HFNC
high density lipoprotein
hospitalised patient
Hospitalised patients
Hospitalization
Hospitalized
human DPSC
human DPSCs
hypersensitive C-reactive protein
hypoxia
Identifier
IgA
IgG
IgM
Il -10
IL-1
IL-1 β
IL-2
IL-4
IL-6
immune
Immunoglobulin
Immunological testing
improvement
IMV
inclusion criteria
Infectious disease
Influenza
Influenza virus
informed consent form
injection
Injections
intensive care
intensive care unit
Intravenous injection
Invasive mechanical ventilation
investigator
investigators
ITN-γ
ketone
ketone bodies
Kidney function
Kidney function tests
Killer cell
Laboratory
laboratory examinations
Lactate
lactate dehydrogenase
lactating women
leukocyte
leukocyte enzymes
lipoprotein
lipoprotein A
lipoprotein cholesterol
low density lipoprotein
lung lesion
lung lesions
lymphocyte
Lymphocytes
Macrophage
Magnesium
Medical care
Menopause
Monocytes
mononuclear cell
mononuclear cells
nasal
nasal catheter
natural killer
natural killer cell
neutrophil
Neutrophils
nitrite
NIV
Non-invasive
non-invasive mechanical ventilation
non-squamous epithelial cell
non-squamous epithelial cells
nucleic acid
nucleic acid test
number
objective
observation
occult
occult blood
Other
Other condition
outcome
oxygen
oxygen saturation
parallel group
parasites
partial pressure
participant
Patient
penetration
performed
Peripheral blood
Peritoneal dialysis
phase
phenotype
phosphatase
phosphorus
Placebo
placebo-controlled
Platelet
Platelet count
platelet distribution width
Platelets
Potassium
prealbumin
pregnancy test
pregnant
pressure
Primary outcome
Protein
protocol
random
randomisation
randomization
Randomized
Randomized controlled trial
receive
receiving
recruitment
red blood cell
red blood cells
renal
renal insufficiency
renal replacement therapy
Renmin Hospital
replacement therapy
required
researcher
respiratory
respiratory distress
respiratory infection
respiratory rate
Safety
Saline
saline solution
Sample size
SARS-CoV-2
secondary
Secondary outcomes
serious COVID-19
serum
serum amyloid
severe liver condition
severe pneumonia
single-cell analyses
sodium
specific gravity
Standard deviation
status
stem cell
study period
Study protocol
sugar
syphilis
Systolic blood pressure
T lymphocyte
Th1 cytokine
Th1 cytokines
Th2 cytokine
Th2 cytokines
therapeutic effect
therapeutic effects
time
TNF-a
Total
total bilirubin
Total cholesterol
total protein
traits
Transferrin
treat
Treatment
treatment for COVID-19
triacylglycerol
Trial
triple blinded
TTCI
Tuberculosis
Twenty participant
Twenty participants
university
urea
uric acid
Urine
urobilinogen
Variation
Version
vital signs
Volume
website
White blood cells
with HIV
within 6 months
women
World Health Organization
Wuhan
γ-glutamyl transferase
[DOI] 10.1186/s13063-020-04380-5 PMC 바로가기 [Article Type] Letter
[DOI] 10.1186/s13063-020-04380-5 PMC 바로가기 [Article Type] Letter