Selection of parameters for thermal coronavirus inactivation – a data-based recommendationArticle Published on 2020-07-132022-11-01 Journal: GMS Hygiene and Infection Control [Category] COVID-19, [키워드] applied available data carried caused conditions coronavirus Critical determine equipment Face masks healthcare worker heat high temperature inactivated inactivation Infection material MERS-CoV more difficult novel coronavirus SARS-CoV-2 parameter Personal protective equipment Protein provide rate constant required reuse Sample SARS-CoV SARS-CoV-2 Selection significantly Sterilization temperature thermal inactivation variations was determined [DOI] 10.3205/dgkh000351 PMC 바로가기 [Article Type] Article
A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin stormShort Report Published on 2020-07-072022-10-31 Journal: eLife [Category] COVID-19, SARS, [키워드] ACE ACE2 activate addition addressed Affect affected affecting Analysis analyzed Atypical BALF blood pressure blood vessel bradykinin Brain Bronchoalveolar lavage fluid cause caused Cell changes in China clinical trial clinician collected Combination contribute Control cough COVID-19 COVID-19 patient COVID-19 patients Critical decrease decreased expression degrade develop disease drug effective enzyme expand experiment explain Gene Expression help high temperature Host Human Hyaluronic acid identify increases in individual induce Inflammation life-threatening Lower lung lung cell maintain mechanism Mild molecular mechanism multiple tissue new virus no symptom opposite outcome oxygen uptake Pain Pathogenesis Patient patients with COVID-19 predicted previous study produced provide RAS receptors regulate renin-angiotensin system researcher responsible risk SARS-CoV-2 sequence severe symptom shown Spread storm Symptom Symptoms symptoms of COVID-19 the disease the SARS-CoV-2 virus therapeutic intervention tissue treat treatments for COVID-19 turn vascular dilation vascular permeability virus was increased were used [DOI] 10.7554/eLife.59177 PMC 바로가기 [Article Type] Short Report
Inverse correlation between average monthly high temperatures and COVID-19-related death rates in different geographical areasResearch Published on 2020-06-232022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] Analysis average calculated circulating confirmed COVID-19 case correlation COVID-19 COVID-19-related death dataset death rate Effect Epidemic Europe evaluated geographical area Hemisphere high temperature indicated Infection inverse inverse correlation Italy latitude Local lockdown lombardy Los Angele measure Measures parameter parameters previous study reducing Result retrieved SARS-CoV SARS-CoV-2 selected social distancing statistical statistically significant subsequent temperature the epidemic the United State variable Washington [DOI] 10.1186/s12967-020-02418-5 PMC 바로가기 [Article Type] Research
Temperature Decreases Spread Parameters of the New Covid-19 Case DynamicsArticle Published on 2020-05-032022-10-28 Journal: Biology [Category] COVID-19, [키워드] ARIMA collected Contagion coronavirus disease country COVID-19 decrease Dynamics epidemiological examined External first stage French heat inhibition high temperature initial MERS-CoV New new coronavirus SARS-CoV-2 parameter Predictive public health Region Result SARS-CoV Stage temperature temperature effect temperature sensitivity the epidemic virulence virus weather-dependent virulence [DOI] 10.3390/biology9050094 PMC 바로가기 [Article Type] Article
COVID-19: An International Public Health ConcernResearch Published on 2020-04-012022-10-31 Journal: Central Asian Journal of Global Health [Category] COVID-19, [키워드] absence adhere African bat breathing problem characterized community transmission concern Contact cough COVID-19 COVID-19 epidemic COVID-19 infection COVID-19 pandemic dead gel Health care worker high temperature Human include Incubation period Infection less Mild mode of transmission nausea pangolins positive-sense preventive measure preventive measures Public reservoir of infection RNA SARS-CoV shaking Shortness of breath sick Signs and symptoms single-stranded social distancing specific treatment symptoms of infection tiredness Transmission Vaccine viral infection virus [DOI] 10.5195/cajgh.2020.466 PMC 바로가기 [Article Type] Research
Enhanced Ability of Oligomeric Nanobodies Targeting MERS Coronavirus Receptor-Binding DomainArticle Published on 2019-02-192022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Ability antibody Antibody fragments approved binding conditions coronavirus country cross-neutralization cross-neutralizing dimeric domain effective elevated enhanced extreme greater high temperature MERS MERS-CoV MERS-CoV infection MERS-CoV RBD Middle East monomeric mortality rate Mutation nanobodies Neutralizing Neutralizing activity protease Protein RBD Receptor binding Receptor-binding domain relative reported significantly stability strain syndrome targeting the RBD therapeutic agent therapeutic antibodies Therapeutic antibody Treatment trimeric urea virus [DOI] 10.3390/v11020166 PMC 바로가기 [Article Type] Article
Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans인간 진균 병원체 크립토코커스 네오포르만스에서 칼시뉴린-Crz1 스트레스 반응 전사 네트워크의 해명Research Article Published on 2017-04-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated appear ascomycete ascomycetes Aspergillus fumigatus binding calcineurin calcium calmodulin Candida albican Candida albicans cascade Cell cell wall cellular cna1 conserved contribute Control Cryptococcus neoforman Cryptococcus neoformans docking domain down-regulated downstream Evidence expression of gene Factor function functions fungal fungal pathogen fungal pathogens fungi high temperature involved majority motif mRNA mRNA expression mutant mutants nuclear translocation nucleus P-bodies P-body pathogen pathogenic Pathogens pathway phenotype Phenotypes pheromone phosphatase post-transcriptional levels predicted promote promoter promoter region promoter regions Protein regulate regulated regulatory network responses RNA-sequencing Saccharomyces cerevisiae Serine Signal transduction Signaling small molecule Stress stress granule stress granules stress response survival target target gene Target genes targets threonine Transcription transcription factor transcriptional Transport virulence wild-type [DOI] 10.1371/journal.pgen.1006667 PMC 바로가기 [Article Type] Research Article
A Sweet Spot for Molecular Diagnostics: Coupling Isothermal Amplification and Strand Exchange Circuits to GlucometersArticle Published on 2015-06-082022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Amplicon amplicons amplified approved biological sample can be used cell lysate circuit coupling Ebolavirus exchange Glucose high temperature isothermal isothermal amplification Loop-mediated isothermal amplification non-specific nucleic acid nucleic acid amplification point-of-care probe respiratory syndrome coronavirus Saliva sensitivity spot sputum strand triggered virus detection Zaire [DOI] 10.1038/srep11039 PMC 바로가기 [Article Type] Article
A Thermolabile Aldolase A Mutant Causes Fever-Induced Recurrent Rhabdomyolysis without Hemolytic Anemia열불안정성 알돌라제 A 돌연변이는 용혈성 빈혈 없이 발열로 인한 재발성 횡문근 융해증을 유발합니다Research Article Published on 2014-11-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulated affected ALDOA Aldolase arginine arginine supplementation betaine cause chaperones Cytokines deficiency Deleterious Dexamethasone droplet erythrocytes Exacerbation expand febrile glycerol hemolytic hemolytic anemia high temperature homozygous mutation illnesses in vitro Lipid lipid droplets mechanism myoblast myoblasts Myoglobinuria Myopathy Patient Protein Recurrent reduced reported rescued rhabdomyolysis severe disease thermolability tissue specific Treatment triggered was increased [DOI] 10.1371/journal.pgen.1004711 PMC 바로가기 [Article Type] Research Article