A SARS-CoV-2-specific CAR-T-cell model identifies felodipine, fasudil, imatinib, and caspofungin as potential treatments for lethal COVID-19article Published on 2023-03-022024-09-05 Journal: Cellular & molecular immunology [Category] update2024, [키워드] Anti-inflammation CAR-T chronic inflammation COVID-19 High-throughput screening NF-κB pathway SARS-CoV-2 viral infection [DOI] 10.1038/s41423-023-00985-3 PMC 바로가기 [Article Type] article
Liposome-based high-throughput and point-of-care assays toward the quick, simple, and sensitive detection of neutralizing antibodies against SARS-CoV-2 in patient seraarticle Published on 2023-02-092024-09-05 Journal: Analytical and Bioanalytical Chemistry [Category] update2024, [키워드] High-throughput screening liposomes Neutralizing antibodies point-of-care diagnostics SARS-CoV-2 [DOI] 10.1007/s00216-023-04548-3 PMC 바로가기 [Article Type] article
Inhibiting the transcription and replication of Ebola viruses by disrupting the nucleoprotein and VP30 protein interaction with small moleculesArticle Published on 2023-02-092024-09-05 Journal: Acta pharmacologica Sinica [Category] update2024, [키워드] drug synergy Ebola High-throughput screening minigenome VP30 [DOI] 10.1038/s41401-023-01055-0 PMC 바로가기 [Article Type] Article
Magnetic hydrogel particles improve nanopore sequencing of SARS-CoV-2 and other respiratory virusesarticle Published on 2023-02-072024-09-05 Journal: Burma Med J [Category] update2024, [키워드] Biological techniques Biomarkers Biotechnology Computational biology and bioinformatics Health care High-throughput screening Molecular biology Molecular medicine Sequencing [DOI] 10.1038/s41598-023-29206-7 PMC 바로가기 [Article Type] article
SARS-CoV-2 RNA-dependent RNA polymerase as a target for high-throughput drug screeningarticle Published on 2023-02-032024-09-05 Journal: Future Virology [Category] update2024, [키워드] COVID-19 High-throughput screening nsp12–nsp8–nsp7 RNA-dependent RNA polymerase SARS-CoV-2 [DOI] 10.2217/fvl-2021-0335 PMC 바로가기 [Article Type] article
Development of a robust and convenient dual-reporter high-throughput screening assay for SARS-CoV-2 antiviral drug discoveryArticle Published on 2023-02-012023-07-11 Journal: Antiviral Research [Category] COVID19(2023년), [키워드] assay development High-throughput screening Reporter A549 Reporter SARS-CoV-2. [DOI] 10.1016/j.antiviral.2022.105506 PMC 바로가기
Rapid screening of neuraminidase inhibitors using an at-line nanofractionation platform involving parallel oseltamivir-sensitive/resistant neuraminidase bioassaysArticle Published on 2023-01-042023-06-23 Journal: Journal of chromatography. A [Category] 신종인플루엔자, [키워드] At-line nanofractionation High-throughput screening Lonicera japonica Thunb neuraminidase inhibitors Parallel oseltamivir-sensitive/resistant neuraminidase bioassays. [DOI] 10.1016/j.chroma.2022.463693
ACE2 decoy receptor generated by high-throughput saturation mutagenesis efficiently neutralizes SARS-CoV-2 and its prevalent variants고처리량 포화 돌연변이 유발에 의해 생성된 ACE2 미끼 수용체는 SARS-CoV-2 및 그 유행하는 변이체를 효율적으로 중화합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding ACE2-RBD binding approach binding binding affinity C-terminal cellular receptor changes in convalescent sera Critical critical point D614G decoy receptor domain Effect fused global pandemic glycosylation site High-throughput screening increase in Microarray monoclonal antibodies Mutagenesis mutations neutralization neutralize neutralized Omicron variant Point mutation prevalent protease Protein protein engineering Pseudotyped virus RBD RBD binding RBD-ACE2 receptor Receptor binding domain rescued SARS-CoV-2 SARS-CoV-2 virus significantly single-cell soluble ACE2 Spike protein the SARS-CoV-2 the SARS-CoV-2 virus therapeutic potential Treatment Vaccine variant variants viral entry viral spike protein wild-type [DOI] 10.1080/22221751.2022.2079426 PMC 바로가기 [Article Type] Article
Systematic evaluation of plasma signaling cascades by functional proteomics approaches: SARS-CoV-2 infection as modelArticle Published on 2022-11-012023-07-10 Journal: Proteomics. Clinical applications [Category] COVID19(2023년), [키워드] acute phase reactant antibody COVID-19 Functional proteomics High-throughput screening immune system Inflammation Microarray [DOI] 10.1002/prca.202100100 PMC 바로가기
Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screenArticle Published on 2022-09-072022-11-15 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] ACE2 acute respiratory syndrome administration affecting angiotensin-converting enzyme 2 Antiviral association benefit bifonazole bind binding blocking agent compounds coronavirus coronavirus disease COVID-19 drug Drug discovery effective food High-throughput screening identification infect cell inhibitor interfere K18-hACE2 mice K353 live SARS-CoV-2 nanoluciferase bioreporter. omicron Prevent RBD RBD-ACE2 receptor Receptor binding domain reduce Replication residue SARS-CoV-2 spike glycoprotein spike-pseudotyped virus target receptor the RBD treat variants of concern vesicular stomatitis virus VoC VOCs [DOI] 10.1016/j.ymthe.2022.04.025 PMC 바로가기