Epigenetics at the Intersection of COVID-19 Risk and Environmental Chemical ExposuresCOVID-19 위험과 환경 화학 물질 노출의 교차점에서의 후성 유전학Review Published on 2022-09-012022-09-11 Journal: Current environmental health reports [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Alter among others Chemical contaminant COVID-19 COVID-19 susceptibility disease disrupting Drawing Endocrine Environmental chemicals Epigenetic epigenetic modification epigenetics Evidence exposure host antiviral responses host response immune pathway immune system Immunity Immunologic memory immunomodulation implicated include Infectious disease Inflammation Intersection involved mechanism memory Modification molecular mechanism Numerous Pathways recent Recognition Regulation risk SARS-CoV-2 SARS-CoV-2 virus severe COVID-19 severity Specific susceptibility the SARS-CoV-2 virus viral entry [DOI] 10.1007/s40572-022-00353-9 PMC 바로가기 [Article Type] Review
Delineating COVID-19 immunological features using single-cell RNA sequencingReview article Published on 2022-09-012022-10-05 Journal: The Innovation [Category] 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome Analysis applied cell population cellular coronavirus disease Coronavirus-2 COVID-19 COVID-19 patient dataset feature heterogeneity host response immune immune response immunological Infection limitation molecular mechanism multiple tissue organs Pathogenesis Pathways Perspective reveal RNA sequencing SARS-CoV-2 severity single cells Single-cell RNA sequencing Therapies understanding [DOI] 10.1016/j.xinn.2022.100289 [Article Type] Review article
A Multitrait Locus Regulates Sarbecovirus PathogenesisArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome Analysis approach CCR9 chromosome 9 collaborative cross conserved coronavirus coronavirus disease Coronavirus infection cross CXCR6 disease facilitate Follow-up Genes Genetic genetic determinant genetic mapping Genetic variation GWAS help highly pathogenic Host host response host susceptibility humans identify implementation Infection Infectious disease influence loci locus mice Mortality mouse model outcome outcomes Pathogenesis pathogenic Precision predict Protective regulate sarbecovirus Sarbecoviruses sarbecoviruses. SARS-CoV SARS-CoV infection SARS-CoV-2 SARS-CoV-2 infections severe disease severity strain susceptibility susceptibility allele variety Viral diseases Virus Disease [DOI] 10.1128/mbio.01454-22 PMC 바로가기
SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 miceArticle Published on 2022-08-292022-11-15 Journal: PLoS ONE [Category] SARS, 변종, 치료제, [키워드] activated Analysis Beta Brain Cell challenge COVID-19 COVID-19 pandemic Delta delta variant Delta VOC Differential gene expression disease dose engage ENhance evaluate experiment Gene Expression highest histopathological host response IFN-γ in silico in vivo induce infiltration Inflammation Inflammatory response interferon response K18-hACE2 mice lung lung tissue magnitude mice nasal no significant difference observation Pathogenesis pathology Pneumonia pro-inflammatory cytokine qRT-PCR analysis Receptor binding RNA-sequencing SARS-CoV-2 strain Strains suggested T-cell TCR Total Transmissibility unique Vaccines variants of concern Viral RNA VoC was performed [DOI] 10.1371/journal.pone.0273430 PMC 바로가기
Bimodal distribution pattern associated with the PCR cycle threshold (Ct) and implications in COVID-19 infectionsPCR 주기 역치(Ct)와 관련된 바이모달 분포 패턴 및 COVID-19 감염에 미치는 영향Article Published on 2022-08-252022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, 치료기술, [키워드] 2019-nCoV age bimodal bimodal distribution cell types Chain Reaction Characteristics clinical sample clinical samples Combination Control COVID-19 COVID-19 infection COVID-19 pandemic Ct values cycle threshold disease control Disease progression dissemination distribution DNA epithelial cells examined explain Gender Genome heterogeneity host response implication Infection infection control Integrated DNA Technologies mucosal notable PCR PCR cycle platform polymerase chain reaction positive prevention ranged real-time RT-PCR respiratory respiratory epithelial cells RT-PCR sample collection SARS-CoV-2 stratified TaqPath ThermoFisher Scientific threshold Transmissibility Transmission Viral Viral load viral replication viral variant Viral variants [DOI] 10.1038/s41598-022-18735-2 PMC 바로가기 [Article Type] Article
Cellular heterogeneity in disease severity and clinical outcome: Granular understanding of immune response is keyArticle Published on 2022-08-222022-11-16 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] age cellular cellular heterogeneity Clinical outcome clinical outcomes Comorbidities complex correlation COVID-19 COVID-19 disease COVID-19 disease severity disease severity dysregulation functional Gender genetics granular heterogeneity heterogeneous heterogeneous population highlight Host host response identify immune immune cells Immune profile immune response immunological mechanism impairment Infectious disease information pandemic Patient progression regulated RNA-Seq severity single-cell genomics single-cell genomics. subset the disease with COVID-19 [DOI] 10.3389/fimmu.2022.973070 PMC 바로가기
Mycoplasma pneumoniae Compared to Streptococcus pneumoniae Avoids Induction of Proinflammatory Epithelial Cell Responses despite Robustly Inducing TLR2 Signaling마이코플라스마 폐렴균은 스트렙토코쿠스 폐렴균에 비해 강력하게 TLR2 신호를 유도하면서도 염증성 상피 세포 반응의 유도를 피한다.Article Published on 2022-08-182024-08-24 Journal: Infection and Immunity [Category] 폐렴구균 감염증, [키워드] host response IL-33 IL-8 Mycoplasma pneumoniae Pneumonia primary bronchial epithelial cells Respiratory pathogens Streptococcus pneumoniae TLR10 TLR2
ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19 Research Published on 2022-08-152022-10-05 Journal: Nature Communications [Category] SARS, 바이오마커, 신약개발, 유전자 메커니즘, 임상, 치료법, [키워드] ACE2 alveolar association Cell cells COVID-19 COVID-19 infection eight ELF5 epithelial epithelial cell expressed Factor Factors Gene Expression Genetic genetic study higher risk highlight Host host response immunohistochemistry initiative outcome plasma plasma proteomics predicted Prognosis protein mediator RAB2A Research Respiratory system risk robust SARS-CoV-2 severe COVID-19 single-cell Single-cell RNA sequencing statistical target TMPRSS2 transcription factor [DOI] 10.1038/s41467-022-31999-6 [Article Type] Research
The Host Response to Influenza A Virus Interferes with SARS-CoV-2 Replication during CoinfectionArticle Published on 2022-08-102023-06-24 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 신종인플루엔자, [키워드] Anosmia Endemic H1N1 host response Interference interferon Long COVID pandemic PASC RNA sequencing [DOI] 10.1128/jvi.00765-22 PMC 바로가기
Identifying novel host-based diagnostic biomarker panels for COVID-19: a whole-blood/nasopharyngeal transcriptome meta-analysisCOVID-19에 대한 새로운 호스트 기반 진단 바이오마커 패널 식별: 전혈/비인두 전사체 메타 분석Meta-Analysis Published on 2022-08-032022-09-11 Journal: Molecular Medicine [Category] SARS, 바이오마커, 유전자 메커니즘, 치료기술, [키워드] Accuracy acute respiratory illness acute respiratory illnesses Analysis applied ARI bioinformatics Biomarker Blood Cell cell cycle Characteristics Combination complementary controls COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients COVID-19 sample cross cytokine cytokine production Data integration dataset Defense detect diagnose diagnostic diagnostic biomarker Diagnostic biomarkers Diseases eight enhancement feature gene expression profile Gene ontology HCs healthy control healthy controls Host host gene host response identifying Immune cell improvement Improvements independent indicated induce Infection Inflammatory interferon introduced lack machine learning algorithm Machine learning algorithms marker Meta-analysis nasopharyngeal Nasopharyngeal swab Ontology Pathogenesis pathway pathway enrichment patients with COVID-19 proportion Random forest respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis selected swab sample System Systems biology Transcriptome upregulation Viral virus Whole blood [DOI] 10.1186/s10020-022-00513-5 PMC 바로가기 [Article Type] Meta-Analysis