hub genes – Page 4 – Communicable Diseases Research

The Molecular Mechanism of Multiple Organ Dysfunction and Targeted Intervention of COVID-19 Based on Time-Order Transcriptomic Analysis

시간 순서 Transcriptomic 분석을 기반으로 한 다발성 장기 기능 장애의 분자 메커니즘 및 COVID-19의 표적 개입

Immunology

Published on 2021-08-242022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 치료제,

Comprehensive investigation of RNA-sequencing dataset reveals the hub genes and molecular mechanisms of coronavirus disease 2019 acute respiratory distress syndrome

RNA 시퀀싱 데이터 세트에 대한 포괄적인 조사는 코로나바이러스 질병 2019 급성 호흡 곤란 증후군의 허브 유전자 및 분자 메커니즘을 보여줍니다

Article

Published on 2021-08-012022-09-11
Journal: IET systems biology [Category] 유전자 메커니즘,

[키워드] acute respiratory distress acute respiratory distress syndrome Analysis approach ARDS ARDS patients CD4 Cell complement Comprehensive comprehensive analysis control group coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 ARDS patient cytokine dataset DEGs differentially expressed gene Differentially expressed genes drug eosinophil eosinophils follicular Functional enrichment analysis G-protein Glutamate GSE163426 hub genes Immune cell infiltration infiltration involved Macrophage macrophages mechanism molecular mechanism molecular mechanisms network analysis pathway patients potential molecular receptor respiratory distress Respiratory distress syndrome reveal RNA sequencing RNA-sequencing significantly syndrome T cell T cells was obtained
[DOI] 10.1049/syb2.12034 PMC 바로가기 [Article Type] Article

Network pharmacology and molecular docking analysis on mechanisms of Tibetan Hongjingtian ( Rhodiola crenulata ) in the treatment of COVID-19

Covid-19의 처리에서 티베트 홍지 (Rhodiola crenulata)의 메커니즘에 대한 네트워크 약리학 및 분자 도킹 분석

Prevention, Therapy and Therapeutics

Published on 2021-07-272022-08-31
Journal: Journal of Medical Microbiology [Category] SARS, 유전자 메커니즘, 치료제,

[키워드] (quercetin Analysis Anti-inflammatory applied AutoDock component contagious contagious disease coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine Cytokine storm Cytoscape Discovery Studio disease docking Effect enrichment analyses Genes genomes GO analysis GO annotation Hongjingtian (R. crenulata) hub genes IL-17 IL-1B IL-1β IL-6 immune regulation immune response Inflammatory response inhibiting kaempferol KEGG Kyoto mechanism molecular docking molecular docking analysis network network pharmacology overcome pathway pathway enrichment Pathways potential molecular PPI PPI network Protein–protein interaction quercetin Result retrieved Rhodiola target target gene Target genes targets TCMSP database the cytokine storm TNF TNF-α Treatment
[DOI] 10.1099/jmm.0.001374 PMC 바로가기 [Article Type] Prevention, Therapy and Therapeutics

Therapeutic targets and signaling mechanisms of vitamin C activity against sepsis: a bioinformatics study

패혈증에 대한 비타민 C 활성의 치료 표적 및 신호 메커니즘: 생물정보학 연구

Article

Published on 2021-05-202022-09-11
Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘,

[키워드] accumulating addition assays benefit bioinformatics Bioinformatics analysis Biological functions biological processe Clinical practice conducted coronavirus coronavirus disease coronavirus disease-2019 Effect EGFR epidermal epidermal growth factor evidence of functional growth factor hub genes immune immune dysfunction implicated Inflammation involved JUN Kyoto life-threatening MAPK1 mechanism mitogen mitogen-activated protein kinase molecular mechanism molecular mechanisms network pharmacology Pathways Pneumonia Predictive Protein receptor Sepsis shown Signal transducer and activator of transcription Signaling signaling pathway signaling pathways STAT3 suppression target targets treat Treatment Vitamin C
[DOI] 10.1093/bib/bbaa079 PMC 바로가기 [Article Type] Article

Brain Disease Network Analysis to Elucidate the Neurological Manifestations of COVID-19

COVID-19의 신경학적 징후를 설명하기 위한 뇌 질환 네트워크 분석

Article

Published on 2021-05-012022-09-11
Journal: Molecular neurobiology [Category] SARS, 신약개발, 유전자 메커니즘,

[키워드] Analysis approach association assumed Brain Brain Disease Care catabolic cause Cell cell cycle clinical condition clinical conditions Comorbidity COVID-19 COVID-19 infection COVID-19 patients Disease-gene interaction disorder drug Drug repurposing Effect FIVE gene network Genetic genetic association greater Health Health care Health care system high-density hub genes hub protein IMPROVE infection mechanism investigated involved manifestation metabolic process molecular basis Mortality network network biology neurologic Neurologic comorbidity. neurological manifestation neurological manifestations Neurological symptoms nuclear patients with COVID-19 Protein report Respiratory complications resulting RNA SARS-CoV-2 Transport with COVID-19
[DOI] 10.1007/s12035-020-02266-w PMC 바로가기 [Article Type] Article

Whole-Transcriptome RNA Sequencing Reveals Significant Differentially Expressed mRNAs, miRNAs, and lncRNAs and Related Regulating Biological Pathways in the Peripheral Blood of COVID-19 Patients

전체 전사체 RNA 시퀀싱은 COVID-19 환자의 말초 혈액에서 유의미하게 차별적으로 발현된 mRNA, miRNA, lncRNA 및 관련 조절 생물학적 경로를 나타냅니다

Research Article

Published on 2021-04-012022-09-10
Journal: Mediators of Inflammation [Category] MERS, SARS, 유전자 메커니즘,

[키워드] “cytokine storm” acute respiratory syndrome acute respiratory syndrome coronavirus AKT1 Analysis Antigen antigen processing Biological biosynthetic characterized China coding collected competing control group controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 sample COVID-19 samples CXCL8 cytokine cytokine production Cytokine storm cytotoxicity diagnostic biomarker Diagnostic biomarkers differentially expressed downregulated enrichment analysis excessive cytokine production FCGR2A Functional enrichment analyses Gene ontology glycogen ground-glass opacity healthy controls healthy donor healthy donors highlight hub genes indicated Inflammation Interaction involved leukocyte leukocytes lncRNA long noncoding RNA lung tissues lymphocyte Lymphocytes mechanism Messenger RNA messenger RNAs microRNA MicroRNAs Migration miRNA miRNAs mRNA mRNAs noncoding RNA Noncoding RNAs pandemic Pathogenesis peripheral Peripheral blood positive potential mechanism potential mechanisms PPI presenting protein-protein interaction Regulating Regulation Regulatory respiratory resulting RNA SARS-CoV-2 selected Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathway Significant significantly STAT3 systemic inflammation T cell T cell activation target the healthy therapeutic tissue TLR2 TNFRSF1B upregulated
[DOI] 10.1155/2021/6635925 PMC 바로가기 [Article Type] Research Article

Integrated Bioinformatics Analysis for the Screening of Associated Pathways and Therapeutic Drugs in Coronavirus Disease 2019

코로나바이러스 질병 2019에서 관련 경로 및 치료 약물의 스크리닝을 위한 통합 생물정보학 분석

Article

Published on 2021-04-012022-09-11
Journal: Archives of medical research [Category] SARS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] 2019-nCoV 2019-nCoV coronavirus acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis antiviral drug Antiviral effect antiviral effects approved assist bioinformatics Bioinformatics analysis caused Clinical research Clinical treatment clinically conducted contribute coronavirus Coronavirus infection COVID-19 COVID-2019 database disease drug Effects EGCG Epigallocatechin-3-gallate expression functional enrichment Functional enrichment analysis Genes hub genes human coronavirus human protein human proteins ingredient inhibit inhibitor inhibitors Integrated analysis Interaction involved mechanism MERS MERS-CoV N protein network analysis Novel coronavirus PKA Previous studies progression Protein reduce Research resveratrol SARS-CoV-2 SARS-COV-2 infection screened Screening selected significant pathways significantly Stage targets therapeutic targets trans trans-resveratrol transcriptional regulation Treatment Vaccine virus
[DOI] 10.1016/j.arcmed.2020.11.009 PMC 바로가기 [Article Type] Article

Network-based identification genetic effect of SARS-CoV-2 infections to Idiopathic pulmonary fibrosis (IPF) patients

특발성 폐섬유증(IPF) 환자에 대한 SARS-CoV-2 감염의 네트워크 기반 식별 유전 효과

Article

Published on 2021-03-222022-09-11
Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis association cause common coronavirus coronavirus disease COVID-19 COVID-19 infections dataset differentially expressed differentially expressed gene Differentially expressed genes drug drug molecule drug target fibrosis Gene ontology Genetic genomes hub gene hub genes identify Idiopathic pulmonary fibrosis increased mortality Infection infections Interaction IPF Kyoto lung epithelium cell lung injuries Lung injury miRNA ontology term pathway Patient patients patients with COVID-19 PPI protein-protein interaction protein–protein interactions risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity shared pathway shared pathways Spread suggested synergistic synergistic effect the epidemic the SARS-CoV-2 Transcriptomic analyses transcriptomic analysis virus was performed
[DOI] 10.1093/bib/bbaa235 PMC 바로가기 [Article Type] Article

Exploration and validation of related hub gene expression during SARS-CoV-2 infection of human bronchial organoids

인간 기관지 오르가노이드의 SARS-CoV-2 감염 중 관련 허브 유전자 발현의 탐색 및 검증

Genome Database

Published on 2021-03-162022-09-10
Journal: Human Genomics [Category] 유전자 메커니즘,

[키워드] 3D structure model acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected analyzed Bioinformatics analysis bronchial organoid CCL2 CCL5 coronavirus COVID-19 CXCL1 CXCL10 CXCL8 Cytokines DEGs differentially expressed gene Differentially expressed genes downloaded downregulated gene EGF exploration expressed expression feasibility FGF2 FN1 Gene Expression Gene ontology Genes genomes GEO Health help high mortality hub genes Human bronchial organoids human bronchus ICAM1 identify IL1B IL6 immune response in vitro model Infection infection mechanism infection rate Interaction KEGG Kyoto Microarray MMP9 mRNA mRNA expression Novel coronavirus Novel coronavirus infection pandemic Pathogenesis pathway Pathways patients PBMC PBMCs Potential treatment PPI prognostic protein-protein interaction Protein–protein interaction R software respiratory Result SARS-CoV-2 SARS-COV-2 infection selected severe acute respiratory syndrome Coronavirus significantly suggested System three-dimensional structure Treatment upregulated gene were used
[DOI] 10.1186/s40246-021-00316-5 PMC 바로가기 [Article Type] Genome Database

Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID‐19

Lianhua Qingwen 캡슐에 대한 네트워크 약리학 및 분자 도킹 분석은 Akt1이 COVID-19를 치료하고 예방하는 잠재적인 표적임을 나타냅니다

Original Article

Published on 2020-11-032022-08-31
Journal: Cell Proliferation [Category] MERS, SARS, 유전자 메커니즘, 치료제,

[키워드] AKT1 Analysis Apoptosis Chinese Chinese patent medicine Compound conducted coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 Critical database docking drug target effective enrichment analysis Gene ontology gene target Genes help hub genes identify immune defense immune response indicated Inflammatory response Interaction involved kaempferol KEGG Kyoto Lianhua Qingwen capsule lung Lung injury Luteolin material Medicine molecular docking molecular mechanism naringenin network network pharmacology nine objective Ontology Patient performed pharmacological Pharmacology potential mechanism PPI PPI network Prevent Protein quercetin reduce Result selected Seven shown System targets therapeutic effect therapeutic effects tissue damage Traditional Traditional Chinese medicine treat virus infection was performed wogonin
[DOI] 10.1111/cpr.12949 PMC 바로가기 [Article Type] Original Article