TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
Research Article
[키워드] activated
Activation
acute infection
antiviral activity
approach
Calu-3
cathepsin
Cell
cells
cleaved
COVID-19
E64d
equimolar
furin
furin inhibitor
host cell proteases
human airway cell
human airway cells
human airway epithelial
inhibited
inhibition
knockdown
not affect
produced
protease
proteolytic activation
provide
respiratory tract
S1/S2 site
S2′ site
SARS-CoV-2
SARS-CoV-2 replication
SARS-CoV-2 S
serine protease inhibitor
severe disease
Spike protein
Spread
Surface glycoprotein
targets
the S protein
therapeutic potential
TMPRSS2
TMPRSS2 expression
TMPRSS2 inhibitor
transmembrane serine protease
Treatment
virus entry
virus replication
[DOI] 10.26508/lsa.202000786 PMC 바로가기 [Article Type] Research Article
[DOI] 10.26508/lsa.202000786 PMC 바로가기 [Article Type] Research Article