Efficacy of an Adjuvanted Middle East Respiratory Syndrome Coronavirus Spike Protein Vaccine in Dromedary Camels and AlpacasArticle Published on 2019-03-022022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] alpaca Camel Camels Complete disease Dromedary effective human infections humans humoral immune response interruption Lower MERS-CoV Middle East naïve nasal turbinate Neutralizing one health outbreak protection protein subunit vaccine reduce reduced respiratory risk robust Serum neutralizing antibody significantly spike These data upper airway vaccination Vaccines viral shedding zoonotic zoonotic transmission [DOI] 10.3390/v11030212 PMC 바로가기 [Article Type] Article
Asymptomatic Natural Human Infections With the Simian Malaria Parasites Plasmodium cynomolgi and Plasmodium knowlesi무증상 자연 인간 감염과 시미안 말라리아 기생충 플라스모디움 시노몰기 및 플라스모디움 노울레시Article Published on 2019-03-012024-08-11 Journal: Nanoscale [Category] 말라리아, [키워드] Asymptomatic human infections natural Plasmodium cynomolgi [DOI] 10.1093/infdis/jiy519 PMC 바로가기
Global status of Middle East respiratory syndrome coronavirus in dromedary camels: a systematic reviewReview Published on 2019-02-212022-11-01 Journal: Epidemiology and Infection [Category] Coronavirus, Fulltext, MERS, 조류인플루엔자, [키워드] age Animal pathogens antibody article circulation Clinical sign coronavirus CoV develop disease distribution Dromedary emerging infections Evidence human infections increase Infection infections Intervention knowledge Laboratory measure MERS MERS-CoV MERS-CoV infection MERS-CoV RNA Middle East molecular nasal swab Prevalence Prevent quarantine Research respiratory syndrome coronavirus risk factor seropositive shown Spread syndrome systematic review Viral detection viral shedding virus zoonoses [DOI] 10.1017/S095026881800345X PMC 바로가기 [Article Type] Review
Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading ExoribonucleaseResearch Article Published on 2018-03-062022-10-29 Journal: mBio [Category] Coronavirus, SARS, [키워드] 50% effective concentration absence acute respiratory syndrome animal model Antiviral Antiviral agents antiviral resistance approved attenuate Combined Concentration conserved coronavirus CoV CoV infection CoVs decrease development effective Efficacy ExoN proofreading Exoribonuclease expand GS-5734 human infections humans impair in vitro include Infection infections inhibit interfere Mediated MERS-CoV MHV Middle East murine hepatitis virus mutant Mutation nontoxic Nsp12 nsp14 exoribonuclease nucleoside nucleoside analogs nucleotide prodrug overcome pandemic parent nucleoside passage Pathogenesis phenotype polymerase Proofreading PROTECT Remdesivir reported residue respiratory syndrome coronavirus RNA polymerases SARS-CoV selected severe disease significantly more Substitution therapeutic treat viral fitness virulence virus wild-type zoonotic CoV [DOI] 10.1128/mBio.00221-18 PMC 바로가기 [Article Type] Research Article
MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infectionResearch Article Published on 2018-01-252022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence accessory gene accessory protein acute respiratory distress antiviral response antiviral signaling ARDS binding contribute coronavirus CoV cytoplasm cytoplasmic Evidence expressed expression Fatality rate highly pathogenic host protein human CoV human infections indicate infected cells Infection information inhibited inhibiting innate immune response Interaction interfere involved Isolation KPNA4 mechanism MERS-CoV Middle East mutant NF-κB NLS nuclear nuclear localization signal nucleus pathology Pathways Prevent pro-inflammatory cytokines Protein protein complex Proteins required respiratory syndrome coronavirus retained robust severe pneumonia shown subunit syndrome translocated translocation Transport wild-type virus [DOI] 10.1371/journal.ppat.1006838 PMC 바로가기 [Article Type] Research Article
Diversity of Middle East respiratory syndrome coronaviruses in 109 dromedary camels based on full-genome sequencing, Abu Dhabi, United Arab EmiratesOriginal Article Published on 2017-11-082022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] Abu Arabian Peninsula breakpoint circulating clade coronavirus described Diversity Dromedary Emirate expand gene sequence Genome Human human infections Hypothesis Incubation period junction Lineage lineages MERS MERS-CoV MERS-CoV genome MERS-CoV infection Middle East Middle East respiratory syndrome Coronavirus ORF1b outbreak positive Recombination recombination event Region reported respiratory syndrome coronavirus screened sequence sequenced Sequencing spike subset supported syndrome United Arab Emirate United Arab Emirates virus [DOI] 10.1038/emi.2017.89 PMC 바로가기 [Article Type] Original Article
Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus InfectionArticle Published on 2016-08-192022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Against animal model approved Arabian Peninsula caused clinical development coronavirus death disease Human human infections Human monoclonal antibody Infection infections lack lethal m336 mAb mAbs medical countermeasure MERS-CoV MERS-CoV infection mice Middle East morbidity and mortality Neutralizing outbreak Passive Prophylactic respiratory robust shown Support therapeutic efficacy transgenic mice treated weight loss [DOI] 10.1038/srep31629 PMC 바로가기 [Article Type] Article
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) origin and animal reservoirReview Published on 2016-06-032022-10-28 Journal: Virology Journal [Category] Coronavirus, Fulltext, [키워드] acute respiratory syndrome animal Animal host bat bats Camels coronavirus disease Dromedary East Endemic geographical distribution human infections humans introduced investigated involved MERS-CoV Middle East Middle East respiratory syndrome Novel coronavirus Phylogenetic Population reservoir respiratory responsible sera suggested Surveillance virus [DOI] 10.1186/s12985-016-0544-0 PMC 바로가기 [Article Type] Review
MERS coronavirus: diagnostics, epidemiology and transmissionReview Published on 2015-12-222022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, 핵심논문, [키워드] Acute kidney injury acute respiratory distress acute respiratory syndrome appear Arabian Peninsula Cell close contact Comorbidities conditions coronavirus cough CoV death diagnostics disease Epidemiology Evidence Fever growth HCWs healthcare healthcare worker Human human infections humans Infection Infection prevention influenza-like illness Jeddah Jordan kidney Kingdom Laboratory Lower respiratory tract LRT majority male MERS MERS patient MERS-CoV Middle East Middle East respiratory syndrome Mild MOST multiorgan failure Novel coronavirus occurred Patient Pneumonia polymerase chain reported Respiratory failure Saudi Arabia sensitive sequence severe disease supplementary material Symptoms syndrome transcriptase Transmission underlying disease upper respiratory tract virus virus detection while widespread Zoonotic coronavirus [DOI] 10.1186/s12985-015-0439-5 PMC 바로가기 [Article Type] Review
MERS-CoV geography and ecology in the Middle East: analyses of reported camel exposures and a preliminary risk mapResearch Article Published on 2015-12-182022-10-27 Journal: BMC Research Notes [Category] Coronavirus, [키워드] Analysis approach breadth Camel condition Contact dimension distribution ecological ecological niche environmental condition Host human infections indicated less MERS MERS-CoV MERS-CoV transmission middle Middle East occur occurred Occurrence offer Quantitative reported Reservoir host respiratory syndrome coronavirus Result risk Risk map Spread the disease Transmission virus [DOI] 10.1186/s13104-015-1789-1 PMC 바로가기 [Article Type] Research Article