Enhanced Detection of Viral RNA Species Using FokI-Assisted Digestion of DNA Duplexes and DNA/RNA HybridsDNA 이중체 및 DNA/RNA 하이브리드의 FokI 지원 소화를 사용한 바이러스 RNA 종의 향상된 검출Article Published on 2022-05-102022-09-11 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] addition amplification amplified approaches battery Chain Reaction cleavage Combination complex Critical decrease detection Diagnosis digestion DNA enhanced enzyme fluorescent FokI highlighting human diseases hybrid increase isothermal limit of detection mechanism molecular nucleic acid nucleic acids oligonucleotide oligonucleotides pathogen Pathogens polymerase chain polymerase chain reaction probe proof proof of concept reduced Region reverse transcription RNA RNA molecule RNA molecules Rolling circle amplification SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants Sensitivity and specificity Specy ssDNA the SARS-CoV-2 genome viral RNAs [DOI] 10.1021/acs.analchem.2c00407 PMC 바로가기 [Article Type] Article
Hybrid versus distance learning environment for a paediatric dentistry course and its influence on students’ satisfaction: a cross-sectional studyArticle Published on 2022-05-052022-10-04 Journal: BMC Medical Education [Category] COVID19(2023년), SARS, 임상, [키워드] accounted adopted asked Complete correlated correlation correlation coefficient Course COVID-19 pandemic cross-sectional dental dental education distance Distance learning enrolled Environment hybrid learning Mann-Whitney U test Modification Multiple Paediatric dentistry positive correlation predict predicted recommendation Registered regression analysis retrospective data Satisfaction scale significant effect significantly higher social distancing Spearman statistically significant Support survey was used [DOI] 10.1186/s12909-022-03417-4 PMC 바로가기 [Article Type] Article
Synthesis and in vitro Study of Artemisinin/Synthetic Peroxide-Based Hybrid Compounds against SARS-CoV-2 and CancerSARS-CoV-2 및 암에 대한 아르테미시닌/합성 과산화물 기반 하이브리드 화합물의 합성 및 시험관 내 연구Article Published on 2022-05-042022-09-11 Journal: ChemMedChem [Category] COVID19(2023년), SARS, 치료제, [키워드] active against acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed anti-cancer compounds anti-leukemia agents anti-SARS-CoV-2 anti-SARS-CoV-2 compounds antiviral agent Antiviral agents Artemisinin artemisinin based hybrids. artesunic acid Cancer Cell cell lines Compound coronavirus cytotoxic effect cytotoxic effects demonstrated disease Doxorubicin drug effective hybrid hybrid drug in vitro in vitro activity Infection inhibitory activity leukemia life-threatening Patients with cancer peroxide quinoline reported SARS-CoV-2 SARS-CoV-2 infections selectivity severe acute respiratory syndrome Coronavirus synthesis treat Vero E6 Vero E6 cell VERO E6 cells while [DOI] 10.1002/cmdc.202200005 PMC 바로가기 [Article Type] Article
The Incidence of SARS-CoV-2 Reinfection in Persons With Naturally Acquired Immunity With and Without Subsequent Receipt of a Single Dose of BNT162b2 Vaccine : A Retrospective Cohort StudyBNT162b2 백신의 후속 접종 유무에 관계없이 자연적으로 획득된 면역이 있는 사람의 SARS-CoV-2 재감염 발생률 : 후향적 코호트 연구Randomized Controlled Trial Published on 2022-05-012022-09-11 Journal: Annals of internal medicine [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] Acquired acquired immunity addition BNT162b2 BNT162b2 vaccine combined effect COVID-19 database death eligible Evidence hazard ratio Hospitalization hybrid incidence rate infected with SARS-CoV-2 Infection magnitude Messenger RNA Mortality Naturally naturally acquired immunity of BNT162b2 Older outcome Person Randomized Randomized controlled trial receipt receive Reinfection remained retrospective cohort study risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination service single dose statistically significant subsequent symptomatic disease Trial trials vaccination Vaccine Vaccine-induced immunity variant [DOI] 10.7326/M21-4130 PMC 바로가기 [Article Type] Randomized Controlled Trial
Sub-optimal neutralisation of omicron (B.1.1.529) variant by antibodies induced by vaccine alone or SARS-CoV-2 Infection plus vaccine (hybrid immunity) post 6-months6개월 후 백신 단독 또는 SARS-CoV-2 감염 + 백신(하이브리드 면역)에 의해 유도된 항체에 의한 오미크론(B.1.1.529) 변이체의 차선 중화Article Published on 2022-04-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI Against Anti-RBD IgG antibody B.1.1.529 BBV152 Biotechnology ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine correlation Covaxin Covishield cross-sectional cross-sectional study demonstrated Department exhibited explain foundation four group four groups geometric mean geometric mean titre GMT group groups hybrid Hybrid immunity Immune escape Immunity inactivated India individual Infection limit Live virus Live-virus neutralisation Melinda Gate Melinda Gates moderate natural infection nCoV neutralisation neutralisation assay neutralisation test neutralisation titre Neutralisation titres neutralise neutralising ability omicron Omicron variant outcome Primary outcome quantification Rapid reduction reduction in SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 variant serum Significant Spread subjects tested titre USA vaccinated individual vaccinated individuals vaccination Vaccine variant virus Virus neutralisation [DOI] 10.1016/j.ebiom.2022.103938 PMC 바로가기 [Article Type] Article
HYBRiD: hydrogel-reinforced DISCO for clearing mammalian bodiesHYBRiD: 포유류의 몸을 청소하기 위한 하이드로겔 강화 DISCOArticle Published on 2022-04-012022-09-11 Journal: Nature methods [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] antibody Chest compatibility component components demonstrated dimensions DISCO feature fluorescent hACE2 heterogeneous hybrid immunostaining K18-hACE2 transgenic mice macroscopic mammalian mice nervous system Newborn offer organ organic parvalbumin Protein reporter Research SARS-COV-2 infection solvent three dimensions translational utility Viral viral pathology Visualization [DOI] 10.1038/s41592-022-01427-0 PMC 바로가기 [Article Type] Article
Gauging the Impact of Artificial Intelligence and Mathematical Modeling in Response to the COVID-19 Pandemic: A Systematic ReviewCOVID-19 팬데믹에 대응하여 인공 지능 및 수학적 모델링의 영향 측정: 체계적인 검토Article Published on 2022-03-142022-09-11 Journal: BioMed Research International [Category] SARS, 변종, [키워드] Accuracy Analysis analyzed ARIMA article articles artificial AstraZeneca AUC B.1.1.7 B.1.617.2 Beta BNT162b2 booster dose booster doses conducted COVID-19 COVID-19 virus data-driven Delta Effect Effectiveness Evolution groups hybrid Impact initial intelligence literature review machine learning models mathematical mitigate modeling Moderna mRNA mRNA-1273 Pfizer-BioNTech Precision Predictive model predictive models Prevent Quality researcher response review selected sensitivity specificity Spread spread of COVID-19 validation cohort viral variant Viral variants virus were used while [DOI] 10.1155/2022/7731618 PMC 바로가기 [Article Type] Article
A Hybrid Feature Extraction Method for Nepali COVID-19-Related Tweets ClassificationResearch Article Published on 2022-03-092022-10-31 Journal: Computational Intelligence and Neuroscience [Category] Coronavirus, MERS, SARS, [키워드] AdaBoost classification Classifier COVID-19 dataset death decision evaluate extraction feature Features forest hybrid Infection information machine learning algorithm machine learning classifier media Mental Naïve Bayes negative Nepali language nine outperform perceptron provide Regression second support vector machine tree trees triggered virus viruses [DOI] 10.1155/2022/5681574 PMC 바로가기 [Article Type] Research Article
Hybrid closed-loop glucose control compared with sensor augmented pump therapy in older adults with type 1 diabetes: an open-label multicentre, multinational, randomised, crossover studyRandomized Controlled Trial Published on 2022-03-012022-10-05 Journal: The Lancet. Healthy longevity [Category] 임상, [키워드] adverse event age assigned baseline block Cambridge Characteristics clinically COVID-19 death diabete diabetes effective enrolled event Glucose glycaemic control Haemoglobin hospital hybrid Hydrocortisone Hypothesis insulin intention-to-treat median multicentre occurred Older older adult Open-label participant primary endpoint proportion random randomisation randomised Randomly Registered resulting risk risk factor Safe sequence significantly higher stratified the primary endpoint therapy Treatment with COVID-19 [DOI] 10.1016/S2666-7568(22)00005-8 PMC 바로가기 [Article Type] Randomized Controlled Trial
A Hybrid Soluble gp130/Spike-Nanobody Fusion Protein Simultaneously Blocks Interleukin-6 trans-Signaling and Cellular Infection with SARS-CoV-2하이브리드 가용성 gp130/스파이크-나노바디 융합 단백질은 SARS-CoV-2로 인터루킨-6 트랜스-시그널링 및 세포 감염을 동시에 차단합니다Article Published on 2022-02-232022-09-12 Journal: Journal of Virology [Category] MERS, 진단, [키워드] acute respiratory syndrome addition age anti-inflammatory therapies antibody Antiviral approved assays bind block Cell Clinical use Comorbidities complexes Concentration coronavirus coronavirus disease COVID-19 cytokine receptor Cytokine storm diabetes disease pathology effective fused fusing fusion Glucocorticoid treatment high affinity higher risk hybrid hyperinflammation IL-6 IL-6 receptor IL-6R Immunocompromised patient individual induce infected individuals infected patients Infection inhibitor inhibitors intensive care interleukin-6 life-threatening Lung disease Mild monoclonal antibody monoclonal antibody treatment Multiorgan nanobody pandemic Patient patients Phosphorylation Prevent proliferation Protein RBD Receptor binding domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine severe COVID-19 sgp130 shown Signaling sIL-6R soluble IL-6R Spike protein STAT3 Symptoms symptoms of COVID-19 the SARS-CoV-2 the spike protein therapeutic options therapy trans-signaling trans-signaling. treat Vero cells viral cell viral infection virus-induced hyperinflammation [DOI] 10.1128/JVI.01622-21 PMC 바로가기 [Article Type] Article