The therapeutic potential of inorganic polyphosphate: A versatile physiological polymer to control coronavirus disease (COVID-19)무기다인산의 치료 가능성: 코로나바이러스(COVID-19)를 제어하는 다목적 생리학적 고분자Review Published on 2021-04-152022-09-10 Journal: Theranostics [Category] MERS, SARS, 신약개발, 치료제, [키워드] ACE2 receptor addition airway airway epithelia airways alkaline phosphatase anhydride attachment binding cationic cause caused ciliary Combination coronavirus disease Course COVID-19 damages drug therapy epithelial epithelial cell epithelial cells form Gene Expression glycoprotein help hydrolysis IMPROVE Inhaled initial life cycle metabolic energy molecule MUC1 MUC5AC mucin multiorgan failure Nanoparticles Novel coronavirus novel coronavirus SARS-CoV-2 pandemic Particle phosphatase phosphate physiological Polymer polyp polyphosphate Prevent rationale Research residues SARS-CoV-2 significantly subsequent Support target cells the disease the RBD therapeutic potential therapy transported viral receptor-binding domain virus Virus life cycle [DOI] 10.7150/thno.59535 PMC 바로가기 [Article Type] Review
Purification and preliminary characterization of four Rel homologues from pathogenic bacteria: Implications for species-specific inhibitor designarticle Published on 2021-01-312024-09-01 Journal: Protein Expression and Purification [Category] 세균성이질, [키워드] hydrolysis pppGpp REL stringent response synthesis [Article Type] article
Caged Dexamethasone/Quercetin Nanoparticles, Formed of the Morphogenetic Active Inorganic Polyphosphate, are Strong Inducers of MUC5ACArticle Published on 2021-01-272022-10-30 Journal: Marine Drugs [Category] COVID-19, [키워드] A549 cell addition airway alveolar antiviral activity ATP Bacteria caused cells Compound Concentration coronavirus disease coronavirus SARS-CoV-2 COVID-19 Defense Dexamethasone drug Effect epithelial exhibit expression Gene Expression glycoprotein human alveolar basal epithelial A549 cells human cells hydrolysis impair inorganic mechanism metabolic energy metabolite MUC5AC mucin Nanoparticles oxygen Pathogenesis patients Platelet Polymer polyphosphate Protective quercetin Release respiratory epithelium SARS-CoV-2 scavenging secreted significantly higher significantly increased Strong syndrome [DOI] 10.3390/md19020064 PMC 바로가기 [Article Type] Article
Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential201 Published on 2020-11-182022-10-29 Journal: Open Biology [Category] COVID-19, [키워드] (ADP-ribosyl)hydrolase ADP-ribosylation adverse effect alphavirus Analysis Antiviral antiviral poly(ADP-ribosyl)polymerases binding cellular conserved Coronaviral coronavirus COVID-19 cross-reactivity disease drug design evaluate Features homology Host human macrodomain hydrolysis immune response implicated infections kidney Ligand macrodomain Necrosis non-structural protein 3 PARP14 pharmacological post-translational modification raised Regulation SARS-CoV-2 spleen the Coronaviridae therapeutic targets Togaviridae Viral macrodomain Virus Disease were used X domain [DOI] 10.1098/rsob.200237 PMC 바로가기 [Article Type] 201
The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-RibosylhydrolaseStructure and Assembly Published on 2020-11-062022-10-30 Journal: Journal of Virology [Category] COVID-19, [키워드] activity acute respiratory syndrome addition ADP-ribose ADP-ribosylation affinity animal model Antiviral approved bind binding Biochemistry caused complex Compound conserved coronavirus CoV CoV infection COVID-19 Critical death demonstrated domain ELISAs enzyme enzyme activity enzyme-linked immunosorbent assay functions host response hydrolysis increasingly Mac1 macrodomain MAR MERS-CoV Middle East Modification mono-ADP-ribose nonstructural protein 3 Nsp3 Pathogenesis poly-ADP-ribose potential therapeutic target potential therapy Protein Proteins reagent regulate respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 SARS-related CoV target proteins the SARS-CoV-2 therapeutic strategy therapeutic target unique viral infection viral infections virulence worldwide pandemic [DOI] 10.1128/JVI.01969-20 PMC 바로가기 [Article Type] Structure and Assembly
Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexesResearch Papers Published on 2020-09-012022-10-29 Journal: IUCrJ [Category] COVID-19, [키워드] ADP-ribose ADP-ribose phosphatase domain ADP-ribosylation adRP antiviral therapeutics apo form appear build complexes conformational change conserved coronavirus COVID-19 crystal structure domain ENCODE enzyme FIVE High-resolution homologue Host immune response hydrolysis interfere Ligand Mac1 macrodomain MES molecular target nonstructural protein Nsp3 phosphatase Protein Research respiratory RNA SARS-CoV-2 shown undergo viruses [DOI] 10.1107/S2052252520009653 PMC 바로가기 [Article Type] Research Papers
Glycyrrhetinic acid alleviates hepatic inflammation injury in viral hepatitis disease via a HMGB1-TLR4 signaling pathwayArticle Published on 2020-05-082022-11-01 Journal: International immunopharmacology [Category] Coronavirus, [키워드] Activation alleviate anti-inflammatory agent antibody clinical setting cured cytokine deficiency disease downstream Glycyrrhetinic acid glycyrrhizic acid hepatic injury Hepatitis HMGB1 HMGB1 release human disorder hydrolysis immunological in viral Infection Infectious disease Inflammation Inflammatory Inflammatory diseases Inflammatory response ingredient inhibit inhibited injection Injury involved licorice mechanism MHV mice murine murine hepatitis virus Neutralizing neutralizing antibody occur provide Regulation reported Signaling signaling pathway significantly TCM the cytokine storm therapy TLR4 Treatment triggered variety Viral hepatitis viral-induced [DOI] 10.1016/j.intimp.2020.106578 PMC 바로가기 [Article Type] Article
Essential gene deletions producing gigantic bacteria거대 박테리아를 생성하는 필수 유전자 결실Research Article Published on 2019-06-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accelerated Acinetobacter Analysis antibiotic Antibiotics Bacteria Bacterial Bacterial infections blocked Cell cell wall cell wall synthesis cells cleave consequence conserved creating dead dead cell dead cells deleted Deletion eliminating enzyme Essential feature function functions Genetic Giant giant cell giant cells help hydrolysis identify inactivated independent life lysed lytic transglycosylase mutant mutants Mutation natural transformation osmotic overcome overlapping pathogenic pathway peptide peptidoglycan polymerization precursor predicted produced producing required respond responsible resulting sacculus targets the cell the dead Tn-seq transposon Treatment [DOI] 10.1371/journal.pgen.1008195 PMC 바로가기 [Article Type] Research Article
Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infectionArticle Published on 2017-04-102022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] addition aminopeptidase N APN approach bind binding blocking Cancer Cell cell entry cell entry receptor cell surface coronavirus crystal structure defined drug ectodomain envelope protein function functional functions hydrolysis inhibit inhibited Ligand membrane-bound occur offered peptide prevented progression Protein regulate Structure suppress Therapies tumor cell tumor growth virus virus infection [DOI] 10.1038/srep46045 PMC 바로가기 [Article Type] Article
Biochemical features and antiviral activity of a monomeric catalytic antibody light-chain 23D4 against influenza A virusArticle Published on 2015-06-012023-06-24 Journal: FASEB journal : official publication of the Federa [Category] 신종인플루엔자, [키워드] AFM image hydrolysis Infection suppression [DOI] 10.1096/fj.14-264275