COVID-19: Are we dealing with a multisystem vasculopathy in disguise of a viral infection?Article Published on 2020-07-052023-06-15 Journal: Journal of Thrombosis and Thrombolysis [Category] MERS, SARS, [키워드] ACE2 Endothelium Hemodynamics hypercytokinemia SARS-CoV-2 thrombosis Vasculopathy [DOI] 10.1007/s11239-020-02210-8 PMC 바로가기 [Article Type] Article
Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 PatientsArticle Published on 2020-05-042023-06-15 Journal: Cell Host & Microbe [Category] Fulltext, MERS, [키워드] Bronchoalveolar lavage fluid chemokines coronavirus COVID-19 hypercytokinemia innate immune response interferon response interferon-stimulated genes Metatranscriptomic sequencing SARS-CoV-2 [DOI] 10.1016/j.chom.2020.04.017 PMC 바로가기 [Article Type] Article
Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infectionResearch Article Published on 2019-02-212022-11-01 Journal: JCI Insight [Category] Coronavirus, SARS, [키워드] abrogated absence accumulated acute lung injury acute respiratory syndrome alveolar macrophage anti-spike antibody Antibody Response blockade cause Characteristics Chinese coronavirus CoV Cytokines Deceased demonstrated died driving Effects faster FcγR functional H7N9 hypercytokinemia IgG IL-8 immunoglobulins Infectious disease Inflammation Lung injury Lungs macaque macaques Macrophage response macrophages MCP1 mechanism MERS-CoV middle neutralizing antibody responses Patient patients proinflammatory promoted Pulmonology recruitment reduced response responsible SARS patient SARS-CoV SARS-CoV infection sera specimens syndrome Treatment viral clearance viruses [DOI] 10.1172/jci.insight.123158 PMC 바로가기 [Article Type] Research Article
Current and future developments in the treatment of virus-induced hypercytokinemiaArticle Published on 2017-01-272023-05-31 Journal: Future Medicinal Chemistry [Category] Fulltext, 조류인플루엔자, [키워드] emerging viruses hypercytokinemia Treatment [DOI] 10.4155/fmc-2016-0181 PMC 바로가기
Apoptosis, cytokine and chemokine induction by non-structural 1 (NS1) proteins encoded by different influenza subtypesResearch Published on 2011-12-212023-05-31 Journal: Virology Journal [Category] Fulltext, [키워드] Apoptosis Avian Influenza hypercytokinemia Inflammation NS1 pandemic influenza Pathogenesis [DOI] 10.1186/1743-422X-8-554 PMC 바로가기 [Article Type] Research
Human immunopathogenesis of severe acute respiratory syndrome (SARS)Article Published on 2007-03-192022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome Adaptive immune response cellular chemokine Clinical course Complete complex cytokine dysregulated hallmark Host host immune system host immunity host response Human human host hypercytokinemia IFN Immunity immunological Immunopathogenesis immunopathology Impact imperative Infected infectious Inflammatory response Injury Innate immunity interferon mechanism Microarray molecular morbidity Progressive Protective Research response resulting SARS SARS Coronavirus SARS CoV SARS patients severe pathology severe SARS suggested systematic analysis type I [DOI] 10.1016/j.virusres.2007.02.014 PMC 바로가기 [Article Type] Article