Drivers of adaptive evolution during chronic SARS-CoV-2 infections만성 SARS-CoV-2 감염 중 적응 진화의 동인Article Published on 2022-07-012022-09-11 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive antibody chronic infection chronic infections coronavirus correlated driver Drivers Evidence Evolution feature Hypothesis immune system Immunocompromised patient in some Infection MOST Most patients Mutation Patient patients Population reflected SARS-CoV-2 SARS-COV-2 infection searched Sequencing subset Substitution tested Transmissibility Transmission variants variants of concern VoC VOCs [DOI] 10.1038/s41591-022-01882-4 PMC 바로가기 [Article Type] Article
Variant of Concern-Matched COVID-19 Convalescent Plasma Usage in Seronegative Hospitalized Patients혈청 음성 입원 환자에서 우려 일치 COVID-19 회복기 혈장 사용의 변형Article Published on 2022-06-302022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 28-day mortality advanced disease Adverse reaction Adverse reactions affecting age anti-spike monoclonal antibodies anti-spike monoclonal antibody Anti-viral therapy Blood donors CCP collected convalescent convalescent plasma COVID-19 COVID-19 convalescent plasma Delta Efficacy hospital Hospitalized hospitalized COVID-19 patient hospitalized patient Immunocompromised Immunocompromised patient Immunocompromised patients infused IQR Italian mAb mAbs median age mortality rate NAbs Neutralizing antibodies neutralizing antibody omicron outcome patients protective immune response Randomized controlled trial recipient reported rescued SARS-CoV-2 seronegative severe COVID-19 Support Two patient two patients Usage variants variants of concern VoC VOCs were recorded [DOI] 10.3390/v14071443 PMC 바로가기 [Article Type] Article
Emergence of SARS-CoV-2 Spike Mutations during Prolonged Infection in Immunocompromised Hosts면역이 저하된 숙주에서 장기간 감염되는 동안 SARS-CoV-2 스파이크 돌연변이의 출현Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 case sery clinically Containment Containment measure containment measures coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated described Early detection emergence escape mutation Evidence genomic globe highlight Host Immunocompromised immunocompromised hosts Immunocompromised patient Immunocompromised patients implicated Infection infection control Measures mutated Mutation pandemic PCR positivity persistent infections Prolonged Prolonged COVID-19 public health respiratory reverse transcription SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants Sequence analysis spike spike mutation spike mutations Spike protein sustained the spike protein therapeutic Therapeutics Treatment unique Vaccine variant variants [DOI] 10.1128/spectrum.00791-22 PMC 바로가기 [Article Type] Article
Immune Response after 2 Doses of BNT162b2 mRNA COVID-19 Vaccinations in Children and Adolescents with Cancer and Hematologic DiseasesArticle Published on 2022-06-012022-11-15 Journal: Asian Pacific Journal of Cancer Prevention : APJCP [Category] COVID19(2023년), SARS, 진단, [키워드] 95%CI Administered Adolescent analyzed anti-SARS-CoV-2 antibody blood sample BNT162b2 mRNA BNT162b2 vaccine Cancer children collected Complete COVID-19 COVID-19 infection COVID-19 vaccine defined Delta Delta strain disease dose enrolled evaluate GMT hematologic Hematologic malignancy high risk IgG immune response Immunocompromised patient immunogenicity Immunoglobulin immunosuppressive agent immunosuppressive drugs mRNA mRNA COVID-19 vaccine. of BNT162b2 offered Patient Patients with cancer pediatric pediatric cancer prospective cohort study RBD receive receiving Receptor binding domain response S-RBD S1 domain SARS-CoV-2 SARS-CoV-2 vaccine serum severe symptom solid tumor sVNT the spike protein Treatment vaccination viral neutralization was determined [DOI] 10.31557/APJCP.2022.23.6.2049 PMC 바로가기
Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the hostArticle Published on 2022-05-102022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome analyzed Antimicrobial responses changes in coronavirus Course COVID-19 described determine diagnostics event Evolution facilitated Frequency Host hosts humoral immune escape mutation immune parameter immune responses Immunity immunocompromised individuals Immunocompromised patient immunological Infection Mutation naso-pharyngeal swabs Next-generation sequencing Non-synonymous Non-synonymous mutation populations prolonged viral shedding public health reported RT-PCR SARS-CoV-2 SARS-CoV-2 mutation Seven severe combined immunodeficiency SIGN specific mutation T cell target the SARS-CoV-2 genome Threats Vaccine variants of concern viral evolution Viral genetics viral shedding VoC VOCs [DOI] 10.1038/s41467-022-30163-4 PMC 바로가기 [Article Type] Article
Adaptive Immune Responses and Immunity to SARS-CoV-2SARS-CoV-2에 대한 적응 면역 반응 및 면역Review Published on 2022-05-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] activated Activation adaptive Adaptive immune response adaptive immune responses Adaptive immunity Antigen antigen-presenting cell antigen-presenting cells B cell B cell receptors B.1.1.529 B.1.617.2 backbone biological interaction Blood Blood donors Breakthrough infection breakthrough infections cellular Cellular immune response cellular immunity cellular response Clonality competence COVID-19 COVID-19 pandemic defend Defense defense mechanism Delta demonstrated heparinized blood Host humoral Humoral response humoral responses IgA immune immune reaction immune responses Immunity Immunocompromised Immunocompromised patient Immunocompromised patients Immunological memory immunology induce Infection interferon gamma interferon gamma. Interferon-gamma knowledge long-lasting maturation mechanism memory mucosal nasal omicron pandemic peptides Research response SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 T cell memory shown stimulated T cell T cell memory T cells the SARS-CoV-2 translate undetectable Vaccine Vaccines variants variants of concern Viral antigen viral particle virus [DOI] 10.3389/fimmu.2022.848582 PMC 바로가기 [Article Type] Review
Humoral Responses Against Variants of Concern by COVID-19 mRNA Vaccines in Immunocompromised Patients면역 저하 환자의 COVID-19 mRNA 백신에 의한 우려 변종에 대한 체액 반응Article Published on 2022-05-012022-09-11 Journal: JAMA Oncology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 2019-nCoV Against age All participant All participants Alpha anti-spike antibody Antibody titer Antibody titers association Autoimmune disease Autoimmune diseases best Beta Beta variant binding BNT162b2 BNT162b2 vaccine BNT162b2 vaccines Cancer cancers circulating concern conducted COVID-19 decrease Delta delta variant Delta variants dose Effectiveness elicited enrolled female Gamma greater healthy control healthy controls hematologic Humoral response humoral responses IgG Immunocompromised patient Immunocompromised patients median Messenger RNA Moderna mRNA mRNA vaccine mRNA-1273 NAb NAb responses NAbs nCoV neutralizing antibody neutralizing antibody titers outcome participant Participants Patient patient population performed persistence Pfizer-BioNTech Primary outcome proportion proportions response response to vaccination responses against SARS-CoV-2 SARS-CoV-2 variants secondary outcome solid cancers solid organ solid organ transplant solid organ transplants study group the healthy the patient the SARS-CoV-2 Treatment underlying disease university vaccination vaccination schedule Vaccine Vaccines variant variants variants of concern VoC VOCs were measured [DOI] 10.1001/jamaoncol.2022.0446 PMC 바로가기 [Article Type] Article
Immunogenicity of BNT162b2 vaccine against the Alpha and Delta variants in immunocompromised patients with systemic inflammatory diseases전신 염증성 질환이 있는 면역 저하 환자에서 알파 및 델타 변이체에 대한 BNT162b2 백신의 면역원성Article Published on 2022-05-012022-09-11 Journal: Annals of the rheumatic diseases [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] abrogated Alpha alpha and delta variants analysed anti-spike antibodies anti-spike antibody anti-Spike IgG B-cell B.1.617.2 BNT162b2 BNT162b2 vaccine Breakthrough infection breakthrough infections Control controls COVID-19 Delta delta variant Delta variants dose effort Endpoint evaluate exhibiting healthcare humoral Humoral response Immune escape immunocompromised individual immunocompromised individuals Immunocompromised patient Immunocompromised patients immunogenicity impairing IMPROVE individual infected with SARS-CoV-2 Inflammatory diseases Kinetics methotrexate mounted neutralisation neutralising Neutralising activity of BNT162b2 Other Patient primary endpoints Prospective raise regimen responses rituximab SARS-CoV-2 secondary Secondary endpoints sera Seroconversion Specific T-cell response strain Strains Support systemic inflammatory disease systemic inflammatory diseases T-cell T-cell Response T-cell responses therapeutic treated vaccination Vaccine Viral viral fitness [DOI] 10.1136/annrheumdis-2021-221508 PMC 바로가기 [Article Type] Article
Evaluation of Humoral and Cellular Immune Responses to the SARS-CoV-2 Vaccine in Patients With Common Variable Immunodeficiency Phenotype and Patient Receiving B-Cell Depletion Therapy공통 가변성 면역결핍 표현형 환자 및 B-세포 고갈 요법을 받는 환자에서 SARS-CoV-2 백신에 대한 체액 및 세포 면역 반응 평가Article Published on 2022-04-292022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] Analysis anti-CD20 anti-CD20 therapies anti-S IgG antibodies Antibody Response B-cell baseline biochemical blood sample CD19+ cellular cellular response chemiluminescence immunoassay Clinical practice common COVID-19 criteria CVID depleting Depletion determine diagnosed Effectiveness Factor humoral IgA immune response Immunocompromised patient Immunocompromised patients immunodeficiency Immunological analyses Immunosuppression in healthy individuals memory B cells multiple sclerosis participant Patient patients patients treated performed peripheral B cells phenotype predict Predictive predictor Prospective Study receive response Safe SARS-CoV-2 SARS-CoV-2 vaccine subject syndrome T-cell specific the SARS-CoV-2 therapy treated vaccination Vaccine Vaccines variable was used were excluded [DOI] 10.3389/fimmu.2022.895209 PMC 바로가기 [Article Type] Article
In vivo imaging of invasive aspergillosis with 18 F-fluorodeoxysorbitol positron emission tomography18 F-플루오로데옥시소르비톨 양전자 방출 단층 촬영을 사용한 침습성 아스페르길루스증의 생체 내 영상화Article Published on 2022-04-082022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] aspergillosis Aspergillus Aspergillus fumigatus Brain can be used caused clinical information clinical outcomes Combination Critical detect Diagnosis Diagnostic method differential diagnosis Hematologic malignancy Immunocompromised patient Immunocompromised patients induce Infection infections Influenza Influenza virus invasive Localization Lungs Mouse models muscle muscles pet Pneumonia positron emission Positron emission tomography pulmonary aspergillosis pulmonary infiltrate pulmonary infiltrates Staphylococcus aureus time-consuming tomography Viral Viral pneumonia [DOI] 10.1038/s41467-022-29553-5 PMC 바로가기 [Article Type] Article